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. 1999 Apr;79(11-12):1935–1937. doi: 10.1038/sj.bjc.6690308

Low frequency of germline E-cadherin mutations in familial and nonfamilial gastric cancer

J Stone 1, S Bevan 1, D Cunningham 2, A Hill 2, N Rahman 1, J Peto 3, A Marossy 1, R S Houlston 1
PMCID: PMC2362779  PMID: 10206317

Abstract

Little is known about the relative contributions of genetic and environmental factors to the development of gastric cancer. Mutations in the cell adhesion molecule E-cadherin are recognized to be associated with the development of undifferentiated, diffuse and invasive gastric cancers. A recent study of two gastric cancer families has shown that germline mutations in the E-cadherin gene can be causative (Guilford P et al, Nature 1998; 26: 402–405). We have examined the E-cadherin gene for constitutive mutations in a systematic series of 106 gastric cancer patients, 10 with a family history of the disease and 96 sporadic cases. No pathogenic mutations were observed in any of the 106 patients. The results indicate that germline mutations in E-cadherin will not account for more than 3% of gastric cancers. © 1999 Cancer Research Campaign

Keywords: gastric cancer, germline, E-cadherin mutations

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Becker K. F., Atkinson M. J., Reich U., Becker I., Nekarda H., Siewert J. R., Höfler H. E-cadherin gene mutations provide clues to diffuse type gastric carcinomas. Cancer Res. 1994 Jul 15;54(14):3845–3852. [PubMed] [Google Scholar]
  2. Berx G., Cleton-Jansen A. M., Nollet F., de Leeuw W. J., van de Vijver M., Cornelisse C., van Roy F. E-cadherin is a tumour/invasion suppressor gene mutated in human lobular breast cancers. EMBO J. 1995 Dec 15;14(24):6107–6115. doi: 10.1002/j.1460-2075.1995.tb00301.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Guilford P., Hopkins J., Harraway J., McLeod M., McLeod N., Harawira P., Taite H., Scoular R., Miller A., Reeve A. E. E-cadherin germline mutations in familial gastric cancer. Nature. 1998 Mar 26;392(6674):402–405. doi: 10.1038/32918. [DOI] [PubMed] [Google Scholar]
  4. Howson C. P., Hiyama T., Wynder E. L. The decline in gastric cancer: epidemiology of an unplanned triumph. Epidemiol Rev. 1986;8:1–27. doi: 10.1093/oxfordjournals.epirev.a036288. [DOI] [PubMed] [Google Scholar]
  5. Ilyas M., Tomlinson I. P. The interactions of APC, E-cadherin and beta-catenin in tumour development and progression. J Pathol. 1997 Jun;182(2):128–137. doi: 10.1002/(SICI)1096-9896(199706)182:2<128::AID-PATH839>3.0.CO;2-Q. [DOI] [PubMed] [Google Scholar]
  6. LAUREN P. THE TWO HISTOLOGICAL MAIN TYPES OF GASTRIC CARCINOMA: DIFFUSE AND SO-CALLED INTESTINAL-TYPE CARCINOMA. AN ATTEMPT AT A HISTO-CLINICAL CLASSIFICATION. Acta Pathol Microbiol Scand. 1965;64:31–49. doi: 10.1111/apm.1965.64.1.31. [DOI] [PubMed] [Google Scholar]
  7. La Vecchia C., Negri E., Franceschi S., Gentile A. Family history and the risk of stomach and colorectal cancer. Cancer. 1992 Jul 1;70(1):50–55. doi: 10.1002/1097-0142(19920701)70:1<50::aid-cncr2820700109>3.0.co;2-i. [DOI] [PubMed] [Google Scholar]
  8. Lehtola J. Family study of gastric carcinoma; With special reference to histological types. Scand J Gastroenterol Suppl. 1978;50:3–54. [PubMed] [Google Scholar]
  9. Lo S. S., Wu C. W., Hsieh M. C., Kuo H. S., Lui W. Y., P'Eng F. K. Relationship between age and clinical characteristics of patients with gastric cancer. J Gastroenterol Hepatol. 1996 Jun;11(6):511–514. doi: 10.1111/j.1440-1746.1996.tb01693.x. [DOI] [PubMed] [Google Scholar]
  10. Mecklin J. P., Nordling S., Saario I. Carcinoma of the stomach and its heredity in young patients. Scand J Gastroenterol. 1988 Apr;23(3):307–311. doi: 10.3109/00365528809093870. [DOI] [PubMed] [Google Scholar]
  11. Muta H., Noguchi M., Kanai Y., Ochiai A., Nawata H., Hirohashi S. E-cadherin gene mutations in signet ring cell carcinoma of the stomach. Jpn J Cancer Res. 1996 Aug;87(8):843–848. doi: 10.1111/j.1349-7006.1996.tb02109.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Oda T., Kanai Y., Oyama T., Yoshiura K., Shimoyama Y., Birchmeier W., Sugimura T., Hirohashi S. E-cadherin gene mutations in human gastric carcinoma cell lines. Proc Natl Acad Sci U S A. 1994 Mar 1;91(5):1858–1862. doi: 10.1073/pnas.91.5.1858. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Risinger J. I., Berchuck A., Kohler M. F., Boyd J. Mutations of the E-cadherin gene in human gynecologic cancers. Nat Genet. 1994 May;7(1):98–102. doi: 10.1038/ng0594-98. [DOI] [PubMed] [Google Scholar]
  14. Shiozaki H., Oka H., Inoue M., Tamura S., Monden M. E-cadherin mediated adhesion system in cancer cells. Cancer. 1996 Apr 15;77(8 Suppl):1605–1613. doi: 10.1002/(SICI)1097-0142(19960415)77:8<1605::AID-CNCR28>3.0.CO;2-2. [DOI] [PubMed] [Google Scholar]
  15. Tamura G., Sakata K., Nishizuka S., Maesawa C., Suzuki Y., Iwaya T., Terashima M., Saito K., Satodate R. Inactivation of the E-cadherin gene in primary gastric carcinomas and gastric carcinoma cell lines. Jpn J Cancer Res. 1996 Nov;87(11):1153–1159. doi: 10.1111/j.1349-7006.1996.tb03125.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Zanghieri G., Di Gregorio C., Sacchetti C., Fante R., Sassatelli R., Cannizzo G., Carriero A., Ponz de Leon M. Familial occurrence of gastric cancer in the 2-year experience of a population-based registry. Cancer. 1990 Nov 1;66(9):2047–2051. doi: 10.1002/1097-0142(19901101)66:9<2047::aid-cncr2820660934>3.0.co;2-g. [DOI] [PubMed] [Google Scholar]

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