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. 1994 Jan;68(1):505–509. doi: 10.1128/jvi.68.1.505-509.1994

Replication of human papillomavirus (HPV) DNAs supported by the HPV type 18 E1 and E2 proteins.

F Sverdrup 1, S A Khan 1
PMCID: PMC236312  PMID: 8254762

Abstract

Transient replication of human papillomavirus (HPV) type 18 DNA was shown to require the viral E1 and E2 proteins. A 108-bp sequence within the long control region (nucleotides 12 to 119) was sufficient to function as the origin, but maximal replication required a region of 177 bp from positions 7800 to 7857 and 1 to 119 of HPV-18. The E1 and E2 proteins of HPV-18 also supported transient replication of plasmids containing the origins of HPV-1a and bovine papillomavirus type 1 to low levels. Interestingly, the level of replication observed with the HPV-6b origin was higher than that obtained with the homologous HPV-18 origin.

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Selected References

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