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. 1999 Aug;80(12):1979–1981. doi: 10.1038/sj.bjc.6690630

Absence of mutations in the ATM gene in forty-seven cases of sporadic breast cancer

D G Bebb 1,2,4, Z Yu 1, J Chen 1, M Telatar 5, K Gelmon 2, N Phillips 3, R A Gatti 5, B W Glickman 1
PMCID: PMC2363154  PMID: 10471049

Abstract

Epidemiological evidence points to an increased risk of breast cancer in ataxia telangiectasia (AT) heterozygote women. Previous attempts to screen early onset or familial breast cancer patients failed to confirm an association. The issue of AT and late onset sporadic breast cancer remained unresolved. We screened 47 women who developed later onset, sporadic breast cancer for ataxia telangiectasia mutated (ATM) mutations. No mutations were found. © 1999 Cancer Research Campaign

Keywords: breast cancer, ataxia telangiectasia, protein truncation test (PTT), cancer predisposition

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Selected References

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