Abstract
The intention was to explore the relationship between fertility and testicular cancer, including the possibly treatment-induced changes over time in the post-diagnostic fertility. Data are from the Norwegian Cancer Registry, The Norwegian Population Register and the Population Censuses. By estimating Poisson regression models, birth rates among testicular cancer patients were compared with those of other men who had the same age, parity and duration since previous birth. Poisson regression models were also estimated to check whether men's parity has an effect on the cancer incidence. Fertility rates among testicular cancer patients born after 1935 and treated before 1991 decreased by roughly 30% when compared with the normal population. The introduction of cisplatin chemotherapy and of nerve-sparing RPLND in the 1980s seems to have enabled more patients with non-seminoma to father a child after treatment, or at least shortened the time to conception. Moreover, the risk of being diagnosed with seminoma is reduced with increasing parity. This suggests that the relatively low fertility after diagnosis may be partly due to the continuing inherent influence of a sub- or infecundity that also had a bearing on the development of the disease. © 2000 Cancer Research Campaign
Keywords: fecundity, incidence, infecundity, infertility, parity, treatment
Full Text
The Full Text of this article is available as a PDF (76.0 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Abbott T, Akiba Y, Beavis D, Bloomer MA, Bond PD, Chasman C, Chen Z, Chu YY, Cole BA, Costales JB. Azimuthal asymmetries of particles emitted in relativistic heavy-ion collisions. Phys Rev Lett. 1993 Mar 8;70(10):1393–1396. doi: 10.1103/PhysRevLett.70.1393. [DOI] [PubMed] [Google Scholar]
- Fosså S. D., Aass N., Ous S., Waehre H. Long-term morbidity and quality of life in testicular cancer patients. Scand J Urol Nephrol Suppl. 1991;138:241–246. [PubMed] [Google Scholar]
- Harvei S., Kravdal O. The importance of marital and socioeconomic status in incidence and survival of prostate cancer. An analysis of complete Norwegian birth cohorts. Prev Med. 1997 Sep-Oct;26(5 Pt 1):623–632. doi: 10.1006/pmed.1997.0153. [DOI] [PubMed] [Google Scholar]
- Jacobsen K. D., Ous S., Waehre H., Trasti H., Stenwig A. E., Lien H. H., Aass N., Fosså S. D. Ejaculation in testicular cancer patients after post-chemotherapy retroperitoneal lymph node dissection. Br J Cancer. 1999 Apr;80(1-2):249–255. doi: 10.1038/sj.bjc.6690347. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kravdal O. Is the relationship between childbearing and cancer incidence due to biology or lifestyle? Examples of the importance of using data on men. Int J Epidemiol. 1995 Jun;24(3):477–484. doi: 10.1093/ije/24.3.477. [DOI] [PubMed] [Google Scholar]
- Møller H., Skakkebaek N. E. Risk of testicular cancer in subfertile men: case-control study. BMJ. 1999 Feb 27;318(7183):559–562. doi: 10.1136/bmj.318.7183.559. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Petersen P. M., Giwercman A., Skakkebaek N. E., Rørth M. Gonadal function in men with testicular cancer. Semin Oncol. 1998 Apr;25(2):224–233. [PubMed] [Google Scholar]
- Wanderås E. H., Tretli S., Fosså S. D. Trends in incidence of testicular cancer in Norway 1955-1992. Eur J Cancer. 1995 Nov;31A(12):2044–2048. doi: 10.1016/0959-8049(95)00321-5. [DOI] [PubMed] [Google Scholar]
- Warde P. R., Gospodarowicz M. K., Goodman P. J., Sturgeon J. F., Jewett M. A., Catton C. N., Richmond H., Thomas G. M., Duncan W., Munro A. J. Results of a policy of surveillance in stage I testicular seminoma. Int J Radiat Oncol Biol Phys. 1993 Sep 1;27(1):11–15. doi: 10.1016/0360-3016(93)90415-r. [DOI] [PubMed] [Google Scholar]