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. 2000 Feb 21;82(6):1183–1185. doi: 10.1054/bjoc.1999.1060

Mutational status of K- ras and TP53 genes in primary sarcomas of the heart

J M Garcia 1, R Gonzalez 1, J M Silva 1, G Dominguez 1, I S Vegazo 2, C Gamallo 3, M Provencio 1, P España 1, F Bonilla 1
PMCID: PMC2363343  PMID: 10735503

Abstract

We investigated three patients with cardiac angiosarcomas and two with cardiac rhabdomyosarcomas, all for mutations at exons 5, 6, 7 and 8 of the p53 gene and at exon 1 of K- ras. No point mutations were observed in the p53 gene in any of the five cases; however, at exon 1 of K- ras, three patients (60%) presented the same mutation at the first base of codon 13 (G to A transition). Interestingly, this mutation was detected in both rhabdomyosarcoma and angiosarcoma histologic sarcoma types. © 2000 Cancer Research Campaign

Keywords: cardiac sarcomas, K-ras mutations, TP53 mutations

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Selected References

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