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. 2000 Feb 21;82(6):1186–1190. doi: 10.1054/bjoc.1999.1061

Placental site trophoblastic tumour: a rare but potentially curable cancer

A M Gillespie 1, D Liyim 1, J R Goepel 2, R E Coleman 1, B W Hancock 1
PMCID: PMC2363347  PMID: 10735504

Abstract

Placental site trophoblastic tumour (PSTT) is a rare form of gestational trophoblastic disease (GTD). We have conducted an analysis of all cases of PSTT managed at the Trophoblastic Disease Screening and Treatment Centre, Sheffield, from 1984 to 1996. During this time we received 4988 registrations for GTD and managed seven cases of PSTT. A large range of interval between antecedent pregnancy and presentation was observed – the most common presenting symptoms being irregular vaginal bleeding with or without preceding amenorrhoea. Three out of seven patients had disease confined to the uterus at diagnosis and were successfully treated by hysterectomy alone. Two out of seven patients had pulmonary metastases in addition to uterine tumour and were treated with combination chemotherapy – both are alive and well. Of the remaining two patients one had distant and the other loco-regional metastases and both died despite numerous therapeutic interventions. © 2000 Cancer Research Campaign

Keywords: placental site trophoblastic tumour, curable, chemosensitive, surgery

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bower M., Paradinas F. J., Fisher R. A., Nicholson S. K., Rustin G. J., Begent R. H., Bagshawe K. D., Newlands E. S. Placental site trophoblastic tumor: molecular analysis and clinical experience. Clin Cancer Res. 1996 May;2(5):897–902. [PubMed] [Google Scholar]
  2. Brewer C. A., Adelson M. D., Elder R. C. Erythrocytosis associated with a placental-site trophoblastic tumor. Obstet Gynecol. 1992 May;79(5 ):846–849. [PubMed] [Google Scholar]
  3. Dessau R., Rustin G. J., Dent J., Paradinas F. J., Bagshawe K. D. Surgery and chemotherapy in the management of placental site tumor. Gynecol Oncol. 1990 Oct;39(1):56–59. doi: 10.1016/0090-8258(90)90398-5. [DOI] [PubMed] [Google Scholar]
  4. Driscoll S. G. Placental-site chorioma. The neoplasm of the implantation-site trophoblast. J Reprod Med. 1984 Nov;29(11):821–825. [PubMed] [Google Scholar]
  5. Finkler N. J., Berkowitz R. S., Driscoll S. G., Goldstein D. P., Bernstein M. R. Clinical experience with placental site trophoblastic tumors at the New England Trophoblastic Disease Center. Obstet Gynecol. 1988 Jun;71(6 Pt 1):854–857. [PubMed] [Google Scholar]
  6. Finkler N. J. Placental site trophoblastic tumor. Diagnosis, clinical behavior and treatment. J Reprod Med. 1991 Jan;36(1):27–30. [PubMed] [Google Scholar]
  7. Fisher R. A., Paradinas F. J., Newlands E. S., Boxer G. M. Genetic evidence that placental site trophoblastic tumours can originate from a hydatidiform mole or a normal conceptus. Br J Cancer. 1992 Mar;65(3):355–358. doi: 10.1038/bjc.1992.72. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Hopkins M., Nunez C., Murphy J. R., Wentz W. B. Malignant placental site trophoblastic tumor. Obstet Gynecol. 1985 Sep;66(3 Suppl):95S–100S. [PubMed] [Google Scholar]
  9. How J., Scurry J., Grant P., Sapountzis K., Ostor A., Fortune D., Armes J. Placental site trophoblastic tumor. Report of three cases and review of the literature. Int J Gynecol Cancer. 1995 Jul;5(4):241–249. doi: 10.1046/j.1525-1438.1995.05040241.x. [DOI] [PubMed] [Google Scholar]
  10. King L. A., Okagaki T., Twiggs L. B. Resolution of pulmonary metastases with chemotherapy in a patient with placental site trophoblastic tumor. Int J Gynecol Cancer. 1992 Nov;2(6):328–331. doi: 10.1046/j.1525-1438.1992.02060328.x. [DOI] [PubMed] [Google Scholar]
  11. Kurman R. J., Scully R. E., Norris H. J. Trophoblastic pseudotumor of the uterus: an exaggerated form of "syncytial endometritis" simulating a malignant tumor. Cancer. 1976 Sep;38(3):1214–1226. doi: 10.1002/1097-0142(197609)38:3<1214::aid-cncr2820380323>3.0.co;2-j. [DOI] [PubMed] [Google Scholar]
  12. Kurman R. J., Young R. H., Norris H. J., Main C. S., Lawrence W. D., Scully R. E. Immunocytochemical localization of placental lactogen and chorionic gonadotropin in the normal placenta and trophoblastic tumors, with emphasis on intermediate trophoblast and the placental site trophoblastic tumor. Int J Gynecol Pathol. 1984;3(1):101–121. doi: 10.1097/00004347-198403010-00009. [DOI] [PubMed] [Google Scholar]
  13. Lathrop J. C., Lauchlan S., Nayak R., Ambler M. Clinical characteristics of placental site trophoblastic tumor (PSTT). Gynecol Oncol. 1988 Sep;31(1):32–42. doi: 10.1016/0090-8258(88)90266-1. [DOI] [PubMed] [Google Scholar]
  14. Nagelberg S. B., Rosen S. W. Clinical and laboratory investigation of a virilized woman with placental-site trophoblastic tumor. Obstet Gynecol. 1985 Apr;65(4):527–534. [PubMed] [Google Scholar]
  15. Scully R. E., Young R. H. Trophoblastic pseudotumor: a reappraisal. Am J Surg Pathol. 1981 Jan;5(1):75–76. doi: 10.1097/00000478-198101000-00010. [DOI] [PubMed] [Google Scholar]
  16. Twiggs L. B., Okagaki T., Phillips G. L., Stroemer J. R., Adcock L. L. Trophoblastic pseudotumor-evidence of malignant disease potential. Gynecol Oncol. 1981 Oct;12(2 Pt 1):238–248. doi: 10.1016/0090-8258(81)90153-0. [DOI] [PubMed] [Google Scholar]
  17. Young R. H., Scully R. E., McCluskey R. T. A distinctive glomerular lesion complicating placental site trophoblastic tumor: report of two cases. Hum Pathol. 1985 Jan;16(1):35–42. doi: 10.1016/s0046-8177(85)80211-2. [DOI] [PubMed] [Google Scholar]

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