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. 2000 Apr 3;82(9):1561–1567. doi: 10.1054/bjoc.1999.1179

Altered expression of members of the IGF-axis in hepatoblastomas

S G Gray 1, T Eriksson 1, C Ekström 1, S Holm 1, D von Schweinitz 2, P Kogner 3, B Sandstedt 4, T Pietsch 5, T J Ekstöm 1
PMCID: PMC2363389  PMID: 10789725

Abstract

Previous reports have demonstrated that expression of insulin-like growth factor 2 (IGF2) is altered in hepatoblastoma. Using RNAase protection analysis (RPA), we examined the gene expression for IGF1, IGF2, IGF1R, M6P/IGF2R, IGFBP-1 and IGFBP-2 in a series of hepatoblastomas with corresponding normal liver from the same individuals. The results show that the expression of the IGF-axis members included in the present study are altered between tumour and normal, and indicate that the IGF-axis may be involved in hepatoblastoma development. © 2000 Cancer Research Campaign

Keywords: hepatoblastoma, insulin-like growth factors, binding proteins

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Selected References

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