Skip to main content
NCBI home page
British Journal of Cancer logoLink to British Journal of Cancer
. 2000 Dec;83(12):1654–1658. doi: 10.1054/bjoc.2000.1524

No evidence of linkage to chromosome 1q42.2–43 in 131 prostate cancer families from the ACTANE Consortium

R Singh 1; the ACTANE Consortium1
PMCID: PMC2363442  PMID: 11104562

Abstract

Genetic linkage studies worldwide have proposed various chromosomal localizations for prostate cancer susceptibility genes. A recent study found evidence for linkage to chromosome 1q42.2–43. The aim of our study was to attempt to confirm these findings by performing linkage analysis in 131 families with multiple prostate cancer cases selected from the ACTANE (Anglo, Canada, Texas, Australia, Norway, EU Biomed) Consortium. Parametric and non-parametric linkage (NPL) analyses were performed. Two-point LOD scores failed to show evidence of linkage at any marker (maximum two-point LOD score = 0.40 at recombination fraction θ = 0.2 with marker D1S2850). Using a multipoint heterogeneity analysis, the estimated proportion of families linked to this putative locus (α) was 0% (95% CI = 0.00–0.33). Non-parametric linkage analysis also found no evidence of linkage (maximum NPL score = –0.12, P = 0.55). This analysis of 131 ACTANE families does not support the presence of a locus for a prostate cancer susceptibility gene at 1q42.2–43. Although we cannot rule out the existence of such a locus, analysis indicates that less than 16% of families could be linked to this region. These findings may be a reflection of the locus heterogeneity involved in this disease indicating that there are still other major susceptibility loci to be identified. © 2000 Cancer Research Campaign http://www.bjcancer.com

Keywords: prostate cancer, linkage, chromosome 1q 42.2–43, PCaP

Full Text

The Full Text of this article is available as a PDF (62.2 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Berthon P., Valeri A., Cohen-Akenine A., Drelon E., Paiss T., Wöhr G., Latil A., Millasseau P., Mellah I., Cohen N. Predisposing gene for early-onset prostate cancer, localized on chromosome 1q42.2-43. Am J Hum Genet. 1998 Jun;62(6):1416–1424. doi: 10.1086/301879. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Broman K. W., Murray J. C., Sheffield V. C., White R. L., Weber J. L. Comprehensive human genetic maps: individual and sex-specific variation in recombination. Am J Hum Genet. 1998 Sep;63(3):861–869. doi: 10.1086/302011. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Carter B. S., Beaty T. H., Steinberg G. D., Childs B., Walsh P. C. Mendelian inheritance of familial prostate cancer. Proc Natl Acad Sci U S A. 1992 Apr 15;89(8):3367–3371. doi: 10.1073/pnas.89.8.3367. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Cooney K. A., McCarthy J. D., Lange E., Huang L., Miesfeldt S., Montie J. E., Oesterling J. E., Sandler H. M., Lange K. Prostate cancer susceptibility locus on chromosome 1q: a confirmatory study. J Natl Cancer Inst. 1997 Jul 2;89(13):955–959. doi: 10.1093/jnci/89.13.955. [DOI] [PubMed] [Google Scholar]
  5. Cottingham R. W., Jr, Idury R. M., Schäffer A. A. Faster sequential genetic linkage computations. Am J Hum Genet. 1993 Jul;53(1):252–263. [PMC free article] [PubMed] [Google Scholar]
  6. Dausset J., Cann H., Cohen D., Lathrop M., Lalouel J. M., White R. Centre d'etude du polymorphisme humain (CEPH): collaborative genetic mapping of the human genome. Genomics. 1990 Mar;6(3):575–577. doi: 10.1016/0888-7543(90)90491-c. [DOI] [PubMed] [Google Scholar]
  7. Eeles R. A., Durocher F., Edwards S., Teare D., Badzioch M., Hamoudi R., Gill S., Biggs P., Dearnaley D., Ardern-Jones A. Linkage analysis of chromosome 1q markers in 136 prostate cancer families. The Cancer Research Campaign/British Prostate Group U.K. Familial Prostate Cancer Study Collaborators. Am J Hum Genet. 1998 Mar;62(3):653–658. doi: 10.1086/301745. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Gibbs M., Chakrabarti L., Stanford J. L., Goode E. L., Kolb S., Schuster E. F., Buckley V. A., Shook M., Hood L., Jarvik G. P. Analysis of chromosome 1q42.2-43 in 152 families with high risk of prostate cancer. Am J Hum Genet. 1999 Apr;64(4):1087–1095. doi: 10.1086/302342. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Grönberg H., Damber L., Damber J. E., Iselius L. Segregation analysis of prostate cancer in Sweden: support for dominant inheritance. Am J Epidemiol. 1997 Oct 1;146(7):552–557. doi: 10.1093/oxfordjournals.aje.a009313. [DOI] [PubMed] [Google Scholar]
  10. Hsieh C. L., Oakley-Girvan I., Gallagher R. P., Wu A. H., Kolonel L. N., Teh C. Z., Halpern J., West D. W., Paffenbarger R. S., Jr, Whittemore A. S. Re: prostate cancer susceptibility locus on chromosome 1q: a confirmatory study. J Natl Cancer Inst. 1997 Dec 17;89(24):1893–1894. doi: 10.1093/jnci/89.24.1893. [DOI] [PubMed] [Google Scholar]
  11. Lange E. M., Chen H., Brierley K., Perrone E. E., Bock C. H., Gillanders E., Ray M. E., Cooney K. A. Linkage analysis of 153 prostate cancer families over a 30-cM region containing the putative susceptibility locus HPCX. Clin Cancer Res. 1999 Dec;5(12):4013–4020. [PubMed] [Google Scholar]
  12. McIndoe R. A., Stanford J. L., Gibbs M., Jarvik G. P., Brandzel S., Neal C. L., Li S., Gammack J. T., Gay A. A., Goode E. L. Linkage analysis of 49 high-risk families does not support a common familial prostate cancer-susceptibility gene at 1q24-25. Am J Hum Genet. 1997 Aug;61(2):347–353. doi: 10.1086/514853. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Narod S. A., Dupont A., Cusan L., Diamond P., Gomez J. L., Suburu R., Labrie F. The impact of family history on early detection of prostate cancer. Nat Med. 1995 Feb;1(2):99–101. doi: 10.1038/nm0295-99. [DOI] [PubMed] [Google Scholar]
  14. Neuhausen S. L., Farnham J. M., Kort E., Tavtigian S. V., Skolnick M. H., Cannon-Albright L. A. Prostate cancer susceptibility locus HPC1 in Utah high-risk pedigrees. Hum Mol Genet. 1999 Dec;8(13):2437–2442. doi: 10.1093/hmg/8.13.2437. [DOI] [PubMed] [Google Scholar]
  15. O'Connell J. R., Weeks D. E. The VITESSE algorithm for rapid exact multilocus linkage analysis via genotype set-recoding and fuzzy inheritance. Nat Genet. 1995 Dec;11(4):402–408. doi: 10.1038/ng1295-402. [DOI] [PubMed] [Google Scholar]
  16. Schaid D. J., McDonnell S. K., Blute M. L., Thibodeau S. N. Evidence for autosomal dominant inheritance of prostate cancer. Am J Hum Genet. 1998 Jun;62(6):1425–1438. doi: 10.1086/301862. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Schäffer A. A., Gupta S. K., Shriram K., Cottingham R. W., Jr Avoiding recomputation in linkage analysis. Hum Hered. 1994 Jul-Aug;44(4):225–237. doi: 10.1159/000154222. [DOI] [PubMed] [Google Scholar]
  18. Smith J. R., Freije D., Carpten J. D., Grönberg H., Xu J., Isaacs S. D., Brownstein M. J., Bova G. S., Guo H., Bujnovszky P. Major susceptibility locus for prostate cancer on chromosome 1 suggested by a genome-wide search. Science. 1996 Nov 22;274(5291):1371–1374. doi: 10.1126/science.274.5291.1371. [DOI] [PubMed] [Google Scholar]
  19. Steinberg G. D., Carter B. S., Beaty T. H., Childs B., Walsh P. C. Family history and the risk of prostate cancer. Prostate. 1990;17(4):337–347. doi: 10.1002/pros.2990170409. [DOI] [PubMed] [Google Scholar]
  20. Suarez B. K., Lin J., Burmester J. K., Broman K. W., Weber J. L., Banerjee T. K., Goddard K. A., Witte J. S., Elston R. C., Catalona W. J. A genome screen of multiplex sibships with prostate cancer. Am J Hum Genet. 2000 Mar;66(3):933–944. doi: 10.1086/302818. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Whittemore A. S., Lin I. G., Oakley-Girvan I., Gallagher R. P., Halpern J., Kolonel L. N., Wu A. H., Hsieh C. L. No evidence of linkage for chromosome 1q42.2-43 in prostate cancer. Am J Hum Genet. 1999 Jul;65(1):254–256. doi: 10.1086/302457. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Xu J. Combined analysis of hereditary prostate cancer linkage to 1q24-25: results from 772 hereditary prostate cancer families from the International Consortium for Prostate Cancer Genetics. Am J Hum Genet. 2000 Mar;66(3):945–957. doi: 10.1086/302807. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Xu J., Meyers D., Freije D., Isaacs S., Wiley K., Nusskern D., Ewing C., Wilkens E., Bujnovszky P., Bova G. S. Evidence for a prostate cancer susceptibility locus on the X chromosome. Nat Genet. 1998 Oct;20(2):175–179. doi: 10.1038/2477. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Cancer are provided here courtesy of Cancer Research UK

RESOURCES