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. 2000 Dec;83(12):1650–1653. doi: 10.1054/bjoc.2000.1519

Screening breast cancer patients for Norwegian ATM mutations

K Laake 1, P Vu 1, T I Andersen 2, B Erikstein 3, R Kåresen 4, P E Lønning 5, E Skovlund 6, A L Børresen-Dale 1
PMCID: PMC2363448  PMID: 11104561

Abstract

483 Norwegian breast cancer patients were screened for six different ataxia telangiectasia mutated (ATM) mutations previously found to account for 83% of the disease alleles in Norwegian ataxia telangiectasia (AT) patients. Only one carrier was found. These results provide no evidence in favour of an excess risk of breast cancer associated with heterozygosity for classical AT mutations, but remain consistent with a maximum 2.4-fold increased risk. © 2000 Cancer Research Campaign http://www.bjcancer.com

Keywords: ataxia telangiectasia, breast neoplasms, heterozygote detection, polymerase chain reaction, breast cancer risk, Norwegian founder mutation

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Selected References

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