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. 2000 Jun 15;83(2):177–183. doi: 10.1054/bjoc.2000.1283

Evidence for susceptibility genes to familial Wilms tumour in addition to WT1, FWT1 and FWT2

E A Rapley 1, R Barfoot 1, C Bonaïti-Pellié 2, A Chompret 2, W Foulkes 3, N Perusinghe 1, A Reeve 4, B Royer-Pokora 5, V Schumacher 5, A Shelling 6, J Skeen 7, S de Tourreil 3, A Weirich 8, K Pritchard-Jones 9, M R Stratton 1, N Rahman 1
PMCID: PMC2363495  PMID: 10901367

Abstract

Three loci have been implicated in familial Wilms tumour: WT1 located on chromosome 11p13, FWT1 on 17q12-q21, and FWT2 on 19q13. Two out of 19 Wilms tumour families evaluated showed strong evidence against linkage at all three loci. Both of these families contained at least three cases of Wilms tumour indicating that they were highly likely to be due to genetic susceptibility and therefore that one or more additional familial Wilms tumour susceptibility genes remain to be found. © 2000 Cancer Research Campaign

Keywords: Wilms tumour, FWT1, FWT2, familial predisposition

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baird P. N., Pritchard J., Cowell J. K. Molecular genetic analysis of chromosome 11p in familial Wilms tumour. Br J Cancer. 1994 Jun;69(6):1072–1077. doi: 10.1038/bjc.1994.210. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Breslow N. E., Olson J., Moksness J., Beckwith J. B., Grundy P. Familial Wilms' tumor: a descriptive study. Med Pediatr Oncol. 1996 Nov;27(5):398–403. doi: 10.1002/(SICI)1096-911X(199611)27:5<398::AID-MPO2>3.0.CO;2-H. [DOI] [PubMed] [Google Scholar]
  3. Collins A., Frezal J., Teague J., Morton N. E. A metric map of humans: 23,500 loci in 850 bands. Proc Natl Acad Sci U S A. 1996 Dec 10;93(25):14771–14775. doi: 10.1073/pnas.93.25.14771. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Cottingham R. W., Jr, Idury R. M., Schäffer A. A. Faster sequential genetic linkage computations. Am J Hum Genet. 1993 Jul;53(1):252–263. [PMC free article] [PubMed] [Google Scholar]
  5. Dib C., Fauré S., Fizames C., Samson D., Drouot N., Vignal A., Millasseau P., Marc S., Hazan J., Seboun E. A comprehensive genetic map of the human genome based on 5,264 microsatellites. Nature. 1996 Mar 14;380(6570):152–154. doi: 10.1038/380152a0. [DOI] [PubMed] [Google Scholar]
  6. Grundy P., Koufos A., Morgan K., Li F. P., Meadows A. T., Cavenee W. K. Familial predisposition to Wilms' tumour does not map to the short arm of chromosome 11. Nature. 1988 Nov 24;336(6197):374–376. doi: 10.1038/336374a0. [DOI] [PubMed] [Google Scholar]
  7. Huff V., Compton D. A., Chao L. Y., Strong L. C., Geiser C. F., Saunders G. F. Lack of linkage of familial Wilms' tumour to chromosomal band 11p13. Nature. 1988 Nov 24;336(6197):377–378. doi: 10.1038/336377a0. [DOI] [PubMed] [Google Scholar]
  8. Kaplinsky C., Ghahremani M., Frishberg Y., Rechavi G., Pelletier J. Familial Wilms' tumor associated with a WT1 zinc finger mutation. Genomics. 1996 Dec 15;38(3):451–453. doi: 10.1006/geno.1996.0655. [DOI] [PubMed] [Google Scholar]
  9. McDonald J. M., Douglass E. C., Fisher R., Geiser C. F., Krill C. E., Strong L. C., Virshup D., Huff V. Linkage of familial Wilms' tumor predisposition to chromosome 19 and a two-locus model for the etiology of familial tumors. Cancer Res. 1998 Apr 1;58(7):1387–1390. [PubMed] [Google Scholar]
  10. Pelletier J., Bruening W., Li F. P., Haber D. A., Glaser T., Housman D. E. WT1 mutations contribute to abnormal genital system development and hereditary Wilms' tumour. Nature. 1991 Oct 3;353(6343):431–434. doi: 10.1038/353431a0. [DOI] [PubMed] [Google Scholar]
  11. Rahman N., Abidi F., Ford D., Arbour L., Rapley E., Tonin P., Barton D., Batcup G., Berry J., Cotter F. Confirmation of FWT1 as a Wilms' tumour susceptibility gene and phenotypic characteristics of Wilms' tumour attributable to FWT1. Hum Genet. 1998 Nov;103(5):547–556. doi: 10.1007/pl00008708. [DOI] [PubMed] [Google Scholar]
  12. Rahman N., Arbour L., Tonin P., Baruchel S., Pritchard-Jones K., Narod S. A., Stratton M. R. The familial Wilms' tumour susceptibility gene, FWT1, may not be a tumour suppressor gene. Oncogene. 1997 Jun 26;14(25):3099–3102. doi: 10.1038/sj.onc.1201107. [DOI] [PubMed] [Google Scholar]
  13. Rahman N., Arbour L., Tonin P., Renshaw J., Pelletier J., Baruchel S., Pritchard-Jones K., Stratton M. R., Narod S. A. Evidence for a familial Wilms' tumour gene (FWT1) on chromosome 17q12-q21. Nat Genet. 1996 Aug;13(4):461–463. doi: 10.1038/ng0896-461. [DOI] [PubMed] [Google Scholar]
  14. Yunis J. J., Ramsay N. K. Familial occurrence of the aniridia-Wilms tumor syndrome with deletion 11p13-14.1. J Pediatr. 1980 Jun;96(6):1027–1030. doi: 10.1016/s0022-3476(80)80630-5. [DOI] [PubMed] [Google Scholar]

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