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. 2000 Nov;83(9):1249–1254. doi: 10.1054/bjoc.2000.1414

Oesophageal cancer among the Turkomans of northeast Iran

F Saidi 1, A Sepehr 2,8, S Fahimi 1, M J Farahvash 3, P Salehian 4, A Esmailzadeh 5, M Keshoofy 6, N Pirmoazen 1, M Yazdanbod 7, M K Roshan 3
PMCID: PMC2363591  PMID: 11027442

Abstract

A Caspian Littoral Cancer Registry survey in the early 1970s established northern Iran as one of the highest oesophageal cancer incidence regions of the world. To verify this, an oesophageal cancer survey was carried out between 1995 and 1997 in the Turkoman Plain at the southeastern corner of the Caspian Sea. Oesophageal balloon cytology screening was carried out on 4192 asymptomatic adults above age 30 years in one town and three adjoining villages with a total population of 20 392 people at risk. Oesophagoscopy was performed on 183 patients with abnormal cytological findings. The discovery of two asymptomatic small squamous cell cancers and one ‘carcinoma- suspect’ implied a prevalence ranging from 47.7 per 100 000 to 71.5 per 100 000. During a 1-year active surveillance, 14 patients were found with clinically advanced oesophageal squamous cell cancer, yielding age-standardized incidence rates of 144.09 per 100 000 for men and 48.82 per 100 000 for women. The very high frequency of oesophageal cancer reported for northern Iran 25 years ago stands confirmed. Differences in incidence rates, then and now, can be attributed to survey methods used and diagnostic criteria applied, but not to socioeconomic factors, which have remained relatively stable. Oesophageal balloon cytology is a practical method of mass screening for oesophageal cancer in Iran. © 2000 Cancer Research Campaign

Keywords: oesophageal cancer, oesophageal balloon cytology, active surveillance, Turkoman Plain

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Selected References

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  1. Cook-Mozaffari P. J., Azordegan F., Day N. E., Ressicaud A., Sabai C., Aramesh B. Oesophageal cancer studies in the Caspian Littoral of Iran: results of a case-control study. Br J Cancer. 1979 Mar;39(3):293–309. doi: 10.1038/bjc.1979.54. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Crespi M., Muñoz N., Grassi A., Aramesh B., Amiri G., Mojtabai A., Casale V. Oesophageal lesions in northern Iran: a premalignant condition? Lancet. 1979 Aug 4;2(8136):217–221. doi: 10.1016/s0140-6736(79)90236-8. [DOI] [PubMed] [Google Scholar]
  3. Dawsey S. M., Lewin K. J., Liu F. S., Wang G. Q., Shen Q. Esophageal morphology from Linxian, China. Squamous histologic findings in 754 patients. Cancer. 1994 Apr 15;73(8):2027–2037. doi: 10.1002/1097-0142(19940415)73:8<2027::aid-cncr2820730803>3.0.co;2-3. [DOI] [PubMed] [Google Scholar]
  4. Dawsey S. M., Shen Q., Nieberg R. K., Liu S. F., English S. A., Cao J., Zhou B., Wang G. Q., Lewin K. J., Liu F. S. Studies of esophageal balloon cytology in Linxian, China. Cancer Epidemiol Biomarkers Prev. 1997 Feb;6(2):121–130. [PubMed] [Google Scholar]
  5. Doll R., Cook P. Summarizing indices for comparison of cancer incidence data. Int J Cancer. 1967 May 15;2(3):269–279. doi: 10.1002/ijc.2910020310. [DOI] [PubMed] [Google Scholar]
  6. Dowlatshahi K., Daneshbod A., Mobarhan S. Early detection of cancer of oesophagus along Caspian Littoral. Report of a pilot project. Lancet. 1978 Jan 21;1(8056):125–126. doi: 10.1016/s0140-6736(78)90421-x. [DOI] [PubMed] [Google Scholar]
  7. Dowlatshahi K., Miller R. J. Role of opium in esophageal cancer: a hypothesis. Cancer Res. 1985 Apr;45(4):1906–1907. [PubMed] [Google Scholar]
  8. Ghadirian P., Stein G. F., Gorodetzky C., Roberfroid M. B., Mahon G. A., Bartsch H., Day N. E. Oesophageal cancer studies in the Caspian littoral of Iran: some residual results, including opium use as a risk factor. Int J Cancer. 1985 May 15;35(5):593–597. doi: 10.1002/ijc.2910350505. [DOI] [PubMed] [Google Scholar]
  9. HABIBI A. CANCER IN IRAN. A SURVEY OF THE MOST COMMON CASES. J Natl Cancer Inst. 1965 May;34:553–569. [PubMed] [Google Scholar]
  10. Haghighi P., Nabizadeh I., Asvadi S., Mohallatee E. A. Cancer in southern Iran. Cancer. 1971 Apr;27(4):965–977. doi: 10.1002/1097-0142(197104)27:4<965::aid-cncr2820270432>3.0.co;2-f. [DOI] [PubMed] [Google Scholar]
  11. Hashemi S., Dowlatshahi K., Day N. E., Kmet J., Takasugi M., Mohaghpour N., Modabber F. Z. Esophageal cancer studies in the Caspian Littoral of Iran: introductive assessment of the HLA profile in patients and controls. Tissue Antigens. 1979 Nov;14(5):422–425. doi: 10.1111/j.1399-0039.1979.tb00870.x. [DOI] [PubMed] [Google Scholar]
  12. Hewer T., Rose E., Ghadirian P., Castegnaro M., Malaveille C., Bartsch H., Day N. Ingested mutagens from opium and tobacco pyrolysis products and cancer of the oesophagus. Lancet. 1978 Sep 2;2(8088):494–496. doi: 10.1016/s0140-6736(78)92218-3. [DOI] [PubMed] [Google Scholar]
  13. Hormozdiari H., Day N. E., Aramesh B., Mahboubi E. Dietary factors and esophageal cancer in the Caspian Littoral of Iran. Cancer Res. 1975 Nov;35(11 Pt 2):3493–3498. [PubMed] [Google Scholar]
  14. Kirk R. L., Keats B., Blake N. M., McDermid E. M., Ala F., Karimi M., Nickbin B., Shabazi H., Kmet J. Genes and people in the Caspian Littoral: a population genetic study in Northern Iran. Am J Phys Anthropol. 1977 May;46(3):377–390. doi: 10.1002/ajpa.1330460302. [DOI] [PubMed] [Google Scholar]
  15. Kmet J., Mahboubi E. Esophageal cancer in the Caspian littoral of Iran: initial studies. Science. 1972 Feb 25;175(4024):846–853. doi: 10.1126/science.175.4024.846. [DOI] [PubMed] [Google Scholar]
  16. Mahboubi E. O., Aramesh B. Epidemiology of esophageal cancer in Iran, with special reference to nutritional and cultural aspects. Prev Med. 1980 Sep;9(5):613–621. doi: 10.1016/0091-7435(80)90033-x. [DOI] [PubMed] [Google Scholar]
  17. Mahboubi E., Kmet J., Cook P. J., Day N. E., Ghadirian P., Salmasizadeh S. Oesophageal cancer studies in the Caspian Littoral of Iran: the Caspian cancer registry. Br J Cancer. 1973 Sep;28(3):197–214. doi: 10.1038/bjc.1973.138. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. O'Neill C. H., Hodges G. M., Riddle P. N., Jordan P. W., Newman R. H., Flood R. J., Toulson E. C. A fine fibrous silica contaminant of flour in the high oesophageal cancer area of north-east Iran. Int J Cancer. 1980 Nov 15;26(5):617–628. doi: 10.1002/ijc.2910260514. [DOI] [PubMed] [Google Scholar]
  19. Pour P., Ghadirian P. Familial cancer of the esophagus in Iran. Cancer. 1974 Jun;33(6):1649–1652. doi: 10.1002/1097-0142(197406)33:6<1649::aid-cncr2820330627>3.0.co;2-0. [DOI] [PubMed] [Google Scholar]
  20. Roth M. J., Liu S. F., Dawsey S. M., Zhou B., Copeland C., Wang G. Q., Solomon D., Baker S. G., Giffen C. A., Taylor P. R. Cytologic detection of esophageal squamous cell carcinoma and precursor lesions using balloon and sponge samplers in asymptomatic adults in Linxian, China. Cancer. 1997 Dec 1;80(11):2047–2059. doi: 10.1002/(sici)1097-0142(19971201)80:11<2047::aid-cncr3>3.0.co;2-u. [DOI] [PubMed] [Google Scholar]
  21. Sadeghi A., Behmard S., Shafiepoor H., Zeighmani E. Cancer of the esophagus in southern Iran. Cancer. 1977 Aug;40(2):841–845. doi: 10.1002/1097-0142(197708)40:2<841::aid-cncr2820400237>3.0.co;2-k. [DOI] [PubMed] [Google Scholar]

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