Skip to main content
British Journal of Cancer logoLink to British Journal of Cancer
letter
. 2001 Jan 1;84(1):116–119. doi: 10.1054/bjoc.2000.1530

Germline TP53 alterations in Finnish breast cancer families are rare and occur at conserved mutation-prone sites

K Rapakko 1,1, M Allinen 1,1, K Syrjäkoski 2, P Vahteristo 3, P Huusko 1, K Vähäkangas 4, H Eerola 3,5, T Kainu 2, O-P Kallioniemi 2, H Nevanlinna 3, R Winqvist 1,6
PMCID: PMC2363618  PMID: 11139324

Abstract

We have screened for germline TP53 mutations in Finnish BRCA1 and BRCA2 mutation-negative families. This study represents the largest survey of the entire protein-encoding portion of TP53, and indicates that mutations are only found at conserved domains in breast cancer families also meeting the criteria for Li-Fraumeni/Li-Fraumeni-like syndrome, explaining only a very small additional fraction of the hereditary breast cancer cases. © 2001 Cancer Research Campaign http://www.bjcancer.com

Keywords: hereditary breast cancer, TP53 mutations, Li-Fraumeni syndrome

Full Text

The Full Text of this article is available as a PDF (86.4 KB).


Articles from British Journal of Cancer are provided here courtesy of Cancer Research UK

RESOURCES