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. 2001 Jun;84(12):1677–1680. doi: 10.1054/bjoc.2001.1833

Fluoropyrimidine sensitivity of human MCF-7 breast cancer cells stably transfected with human uridinehosphorylase

P Cuq 1,2, C Rouquet 1, A Evrard 1, J Ciccolini 2, L Vian 1, J-P Cano 1
PMCID: PMC2363689  PMID: 11401323

Abstract

The relationship between uridine phosphorylase (UP) expression level in cancer cells and the tumour sensitivity to fluoropyrimidines is unclear. In this study, we found that UP overexpression by gene transfer, and the subsequent efficient metabolic activation of 5-fluorouracil (5-FU) by the ribonucleotide pathway, does not increase the fluoropyrimidine sensitivity of MCF-7 human cancer cells. © 2001 Cancer Research Campaign http://www.bjcancer.com

Keywords: uridine phosphorylase, breast cancer, 5-FU, 5′DFUR, cancer gene therapy

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Selected References

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