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. 2001 Feb;84(3):435–440. doi: 10.1054/bjoc.2000.1603

Incidence of multiple primary cancers in a cohort of women diagnosed with breast cancer in southeast England

H S Evans 1, C M Lewis 2, D Robinson 1, C M J Bell 1, H Møller 1, S V Hodgson 2
PMCID: PMC2363744  PMID: 11161413

Abstract

Among women in the Thames Cancer Registry database with a first breast cancer diagnosed between 1961–1995 observed numbers of subsequent cancers were compared with expected numbers and standardized incidence ratios were calculated. The occurrence of breast cancers subsequent to cancers at other sites was also examined. Women diagnosed with breast cancer before age 50 had significantly elevated risks for 9 cancer sites namely, oesophagus, stomach, lung, bone, connective tissue, breast, corpus uteri, ovary and myeloid leukaemia compared with 2 sites (corpus uteri and myeloid leukaemia) in women diagnosed at age 50 and above. Some of these associations are consistent with the effects of known inherited cancer susceptibility genes, shared environmental factors, or therapy. © 2001 Cancer Research Campaign http://www.bjcancer.com

Keywords: multiple primary cancers, cancer genetics, registries, breast cancer

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Selected References

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  1. Adami H. O., Bergkvist L., Krusemo U., Persson I. Breast cancer as a risk factor for other primary malignant diseases. A nationwide cohort study. J Natl Cancer Inst. 1984 Nov;73(5):1049–1055. [PubMed] [Google Scholar]
  2. Andersson M., Storm H. H., Mouridsen H. T. Incidence of new primary cancers after adjuvant tamoxifen therapy and radiotherapy for early breast cancer. J Natl Cancer Inst. 1991 Jul 17;83(14):1013–1017. doi: 10.1093/jnci/83.14.1013. [DOI] [PubMed] [Google Scholar]
  3. Bevan S., Houlston R. S. Genetic predisposition to gastric cancer. QJM. 1999 Jan;92(1):5–10. doi: 10.1093/qjmed/92.1.5. [DOI] [PubMed] [Google Scholar]
  4. De Vivo I., Gertig D. M., Nagase S., Hankinson S. E., O'Brien R., Speizer F. E., Parsons R., Hunter D. J. Novel germline mutations in the PTEN tumour suppressor gene found in women with multiple cancers. J Med Genet. 2000 May;37(5):336–341. doi: 10.1136/jmg.37.5.336. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Easton D. F., Ford D., Bishop D. T. Breast and ovarian cancer incidence in BRCA1-mutation carriers. Breast Cancer Linkage Consortium. Am J Hum Genet. 1995 Jan;56(1):265–271. [PMC free article] [PubMed] [Google Scholar]
  6. Eeles R. A. Germline mutations in the TP53 gene. Cancer Surv. 1995;25:101–124. [PubMed] [Google Scholar]
  7. Ewertz M., Mouridsen H. T. Second cancer following cancer of the female breast in Denmark, 1943-80. Natl Cancer Inst Monogr. 1985 Dec;68:325–329. [PubMed] [Google Scholar]
  8. FitzGerald M. G., Bean J. M., Hegde S. R., Unsal H., MacDonald D. J., Harkin D. P., Finkelstein D. M., Isselbacher K. J., Haber D. A. Heterozygous ATM mutations do not contribute to early onset of breast cancer. Nat Genet. 1997 Mar;15(3):307–310. doi: 10.1038/ng0397-307. [DOI] [PubMed] [Google Scholar]
  9. Ford D., Easton D. F., Bishop D. T., Narod S. A., Goldgar D. E. Risks of cancer in BRCA1-mutation carriers. Breast Cancer Linkage Consortium. Lancet. 1994 Mar 19;343(8899):692–695. doi: 10.1016/s0140-6736(94)91578-4. [DOI] [PubMed] [Google Scholar]
  10. Freihoff D., Kempe A., Beste B., Wappenschmidt B., Kreyer E., Hayashi Y., Meindl A., Krebs D., Wiestler O. D., von Deimling A. Exclusion of a major role for the PTEN tumour-suppressor gene in breast carcinomas. Br J Cancer. 1999 Feb;79(5-6):754–758. doi: 10.1038/sj.bjc.6690121. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Gail M. H., Costantino J. P., Bryant J., Croyle R., Freedman L., Helzlsouer K., Vogel V. Weighing the risks and benefits of tamoxifen treatment for preventing breast cancer. J Natl Cancer Inst. 1999 Nov 3;91(21):1829–1846. doi: 10.1093/jnci/91.21.1829. [DOI] [PubMed] [Google Scholar]
  12. Harvey E. B., Brinton L. A. Second cancer following cancer of the breast in Connecticut, 1935-82. Natl Cancer Inst Monogr. 1985 Dec;68:99–112. [PubMed] [Google Scholar]
  13. Houlston R. S., Stratton M. R. Genetics of non-medullary thyroid cancer. QJM. 1995 Oct;88(10):685–693. [PubMed] [Google Scholar]
  14. Inskip H. M., Kinlen L. J., Taylor A. M., Woods C. G., Arlett C. F. Risk of breast cancer and other cancers in heterozygotes for ataxia-telangiectasia. Br J Cancer. 1999 Mar;79(7-8):1304–1307. doi: 10.1038/sj.bjc.6690209. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Kollmannsberger C., Hartmann J. T., Kanz L., Bokemeyer C. Risk of secondary myeloid leukemia and myelodysplastic syndrome following standard-dose chemotherapy or high-dose chemotherapy with stem cell support in patients with potentially curable malignancies. J Cancer Res Clin Oncol. 1998;124(3-4):207–214. doi: 10.1007/s004320050156. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Liaw D., Marsh D. J., Li J., Dahia P. L., Wang S. I., Zheng Z., Bose S., Call K. M., Tsou H. C., Peacocke M. Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome. Nat Genet. 1997 May;16(1):64–67. doi: 10.1038/ng0597-64. [DOI] [PubMed] [Google Scholar]
  17. Palmer J. R., Rosenberg L. Cigarette smoking and the risk of breast cancer. Epidemiol Rev. 1993;15(1):145–156. doi: 10.1093/oxfordjournals.epirev.a036098. [DOI] [PubMed] [Google Scholar]
  18. Peto J., Collins N., Barfoot R., Seal S., Warren W., Rahman N., Easton D. F., Evans C., Deacon J., Stratton M. R. Prevalence of BRCA1 and BRCA2 gene mutations in patients with early-onset breast cancer. J Natl Cancer Inst. 1999 Jun 2;91(11):943–949. doi: 10.1093/jnci/91.11.943. [DOI] [PubMed] [Google Scholar]
  19. Peto J., Easton D. F., Matthews F. E., Ford D., Swerdlow A. J. Cancer mortality in relatives of women with breast cancer: the OPCS Study. Office of Population Censuses and Surveys. Int J Cancer. 1996 Jan 26;65(3):275–283. doi: 10.1002/(SICI)1097-0215(19960126)65:3<275::AID-IJC1>3.0.CO;2-X. [DOI] [PubMed] [Google Scholar]
  20. Prior P., Waterhouse J. A. Multiple primary cancers of the breast and ovary. Br J Cancer. 1981 Nov;44(5):628–636. doi: 10.1038/bjc.1981.247. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Ron E., Curtis R., Hoffman D. A., Flannery J. T. Multiple primary breast and thyroid cancer. Br J Cancer. 1984 Jan;49(1):87–92. doi: 10.1038/bjc.1984.13. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Schimke R. N. Genetic aspects of multiple endocrine neoplasia. Annu Rev Med. 1984;35:25–31. doi: 10.1146/annurev.me.35.020184.000325. [DOI] [PubMed] [Google Scholar]
  23. Swift M., Reitnauer P. J., Morrell D., Chase C. L. Breast and other cancers in families with ataxia-telangiectasia. N Engl J Med. 1987 May 21;316(21):1289–1294. doi: 10.1056/NEJM198705213162101. [DOI] [PubMed] [Google Scholar]
  24. Teppo L., Pukkala E., Saxén E. Multiple cancer--an epidemiologic exercise in Finland. J Natl Cancer Inst. 1985 Aug;75(2):207–217. [PubMed] [Google Scholar]
  25. Vassilopoulou-Sellin R., Palmer L., Taylor S., Cooksley C. S. Incidence of breast carcinoma in women with thyroid carcinoma. Cancer. 1999 Feb 1;85(3):696–705. doi: 10.1002/(sici)1097-0142(19990201)85:3<696::aid-cncr20>3.0.co;2-4. [DOI] [PubMed] [Google Scholar]
  26. Volk N., Pompe-Kirn V. Second primary cancers in breast cancer patients in Slovenia. Cancer Causes Control. 1997 Sep;8(5):764–770. doi: 10.1023/a:1018487506546. [DOI] [PubMed] [Google Scholar]
  27. Warren W., Eeles R. A., Ponder B. A., Easton D. F., Averill D., Ponder M. A., Anderson K., Evans A. M., DeMars R., Love R. No evidence for germline mutations in exons 5-9 of the p53 gene in 25 breast cancer families. Oncogene. 1992 May;7(5):1043–1046. [PubMed] [Google Scholar]

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