Abstract
A prospective population-based study recorded family trees of 77 colorectal cancer patients younger than 50 years of age. Using mathematical modeling of population age-incidence data, we estimate that 1 (95% confidence limits 0 and 3) of these families is expected to meet the Amsterdam criteria I for HNPCC due to chance clustering of colorectal cancer. © 2001 Cancer Research Campaign http://www.bjcancer.com
Keywords: HNPCC, hereditary non-polyposis colorectal cancer, Amsterdam criteria, incidence, coincidence
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