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. 2001 May;84(9):1193–1198. doi: 10.1054/bjoc.2000.1738

Cancer risk in Swedish women: the relation to size at birth

S W Andersson 1, C Bengtsson 2, L Hallberg 1, L Lapidus 3, A Niklasson 4, A Wallgren 5, L Hulthén 1
PMCID: PMC2363893  PMID: 11336470

Abstract

The relationship between fetal growth as indicated by weight and length at birth, and cancer risk in 1080 adult Swedish women was examined. Birth factors were retrieved from original midwife records for the years 1914, 1918, 1922 and 1930, and primary cancer cases were identified by matching with national and regional cancer registries through the year 1998. A positive and statistically significant increased risk for cancer was found with increasing birth weight or birth length for all site cancer and non-hormone related cancer, defined as all cancer sites excluding breast, uterus and ovary. Addition of factors suspected to influence cancer risk, maternal proteinuria, birth order, own parity and age at menarche, did not attenuate this relation. Previously only breast cancer has been reported to be related to size at birth in adult women and this is the first study to report that cancer sites other than the major hormone-related sites may be influenced by size at birth, as measured by either weight or length at birth; these findings warrant further investigation. © 2001 Cancer Research Campaign http://www.bjcancer.com

Keywords: adult, birth weight, cancer, epidemiology, prenatal, women

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Selected References

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  1. Andersson S. W., Niklasson A., Lapidus L., Hallberg L., Bengtsson C., Hulthén L. Sociodemographic characteristics influencing birth outcome in Sweden, 1908-1930. Birth variables in the Population Study of Women in Gothenburg. J Epidemiol Community Health. 2000 Apr;54(4):269–278. doi: 10.1136/jech.54.4.269. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bengtsson C., Blohmé G., Hallberg L., Hällström T., Isaksson B., Korsan-Bengtsen K., Rybo G., Tibblin E., Tibblin G., Westerberg H. The study of women in Gothenburg 1968-1969--a population study. General design, purpose and sampling results. Acta Med Scand. 1973 Apr;193(4):311–318. doi: 10.1111/j.0954-6820.1973.tb10583.x. [DOI] [PubMed] [Google Scholar]
  3. Brown L. M., Pottern L. M., Hoover R. N. Prenatal and perinatal risk factors for testicular cancer. Cancer Res. 1986 Sep;46(9):4812–4816. [PubMed] [Google Scholar]
  4. D'Ercole A. J. Mechanisms of in utero overgrowth. Acta Paediatr Suppl. 1999 Feb;88(428):31–36. doi: 10.1111/j.1651-2227.1999.tb14348.x. [DOI] [PubMed] [Google Scholar]
  5. Daling J. R., Starzyk P., Olshan A. F., Weiss N. S. Birth weight and the incidence of childhood cancer. J Natl Cancer Inst. 1984 May;72(5):1039–1041. [PubMed] [Google Scholar]
  6. Ekbom A. Growing evidence that several human cancers may originate in utero. Semin Cancer Biol. 1998 Aug;8(4):237–244. doi: 10.1006/scbi.1998.0073. [DOI] [PubMed] [Google Scholar]
  7. Ekbom A., Hsieh C. C., Lipworth L., Adami H. Q., Trichopoulos D. Intrauterine environment and breast cancer risk in women: a population-based study. J Natl Cancer Inst. 1997 Jan 1;89(1):71–76. doi: 10.1093/jnci/89.1.71. [DOI] [PubMed] [Google Scholar]
  8. Ekbom A., Hsieh C. C., Lipworth L., Wolk A., Pontén J., Adami H. O., Trichopoulos D. Perinatal characteristics in relation to incidence of and mortality from prostate cancer. BMJ. 1996 Aug 10;313(7053):337–341. doi: 10.1136/bmj.313.7053.337. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Ekbom A., Trichopoulos D., Adami H. O., Hsieh C. C., Lan S. J. Evidence of prenatal influences on breast cancer risk. Lancet. 1992 Oct 24;340(8826):1015–1018. doi: 10.1016/0140-6736(92)93019-j. [DOI] [PubMed] [Google Scholar]
  10. Helgesson O., Bengtsson C., Lapidus L., Merck C., Sparén P. Malignant disease observed in a cohort of women. A validation of Swedish Cancer Registry data. Scand J Soc Med. 1994 Mar;22(1):46–49. doi: 10.1177/140349489402200108. [DOI] [PubMed] [Google Scholar]
  11. Hsieh C. C., Trichopoulos D., Katsouyanni K., Yuasa S. Age at menarche, age at menopause, height and obesity as risk factors for breast cancer: associations and interactions in an international case-control study. Int J Cancer. 1990 Nov 15;46(5):796–800. doi: 10.1002/ijc.2910460508. [DOI] [PubMed] [Google Scholar]
  12. Janerich D. T., Hayden C. L., Thompson W. D., Selenskas S. L., Mettlin C. Epidemiologic evidence of perinatal influence in the etiology of adult cancers. J Clin Epidemiol. 1989;42(2):151–157. doi: 10.1016/0895-4356(89)90088-7. [DOI] [PubMed] [Google Scholar]
  13. Joseph K. S., Kramer M. S. Review of the evidence on fetal and early childhood antecedents of adult chronic disease. Epidemiol Rev. 1996;18(2):158–174. doi: 10.1093/oxfordjournals.epirev.a017923. [DOI] [PubMed] [Google Scholar]
  14. Lynch H. T., Fusaro R. M., Lynch J. F. Cancer genetics in the new era of molecular biology. Ann N Y Acad Sci. 1997 Dec 29;833:1–28. doi: 10.1111/j.1749-6632.1997.tb48588.x. [DOI] [PubMed] [Google Scholar]
  15. Michels K. B., Trichopoulos D., Robins J. M., Rosner B. A., Manson J. E., Hunter D. J., Colditz G. A., Hankinson S. E., Speizer F. E., Willett W. C. Birthweight as a risk factor for breast cancer. Lancet. 1996 Dec 7;348(9041):1542–1546. doi: 10.1016/S0140-6736(96)03102-9. [DOI] [PubMed] [Google Scholar]
  16. Miller A. B. An overview of hormone-associated cancers. Cancer Res. 1978 Nov;38(11 Pt 2):3985–3990. [PubMed] [Google Scholar]
  17. O'Dell S. D., Day I. N. Insulin-like growth factor II (IGF-II). Int J Biochem Cell Biol. 1998 Jul;30(7):767–771. doi: 10.1016/s1357-2725(98)00048-x. [DOI] [PubMed] [Google Scholar]
  18. Potischman N., Troisi R. In-utero and early life exposures in relation to risk of breast cancer. Cancer Causes Control. 1999 Dec;10(6):561–573. doi: 10.1023/a:1008955110868. [DOI] [PubMed] [Google Scholar]
  19. Potter J. D. Hormones and colon cancer. J Natl Cancer Inst. 1995 Jul 19;87(14):1039–1040. doi: 10.1093/jnci/87.14.1039. [DOI] [PubMed] [Google Scholar]
  20. Sanderson M., Williams M. A., Malone K. E., Stanford J. L., Emanuel I., White E., Daling J. R. Perinatal factors and risk of breast cancer. Epidemiology. 1996 Jan;7(1):34–37. doi: 10.1097/00001648-199601000-00007. [DOI] [PubMed] [Google Scholar]
  21. Stavola B. L., Hardy R., Kuh D., Silva I. S., Wadsworth M., Swerdlow A. J. Birthweight, childhood growth and risk of breast cancer in a British cohort. Br J Cancer. 2000 Oct;83(7):964–968. doi: 10.1054/bjoc.2000.1370. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Tibblin G., Eriksson M., Cnattingius S., Ekbom A. High birthweight as a predictor of prostate cancer risk. Epidemiology. 1995 Jul;6(4):423–424. doi: 10.1097/00001648-199507000-00017. [DOI] [PubMed] [Google Scholar]
  23. Trichopoulos D. Hypothesis: does breast cancer originate in utero? Lancet. 1990 Apr 21;335(8695):939–940. doi: 10.1016/0140-6736(90)91000-z. [DOI] [PubMed] [Google Scholar]
  24. Yeazel M. W., Ross J. A., Buckley J. D., Woods W. G., Ruccione K., Robison L. L. High birth weight and risk of specific childhood cancers: a report from the Children's Cancer Group. J Pediatr. 1997 Nov;131(5):671–677. doi: 10.1016/s0022-3476(97)70091-x. [DOI] [PubMed] [Google Scholar]

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