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. 2001 Jul;85(1):98–101. doi: 10.1054/bjoc.2001.1857

Tcf-3 expression and β -catenin mediated transcriptional activation in aggressive fibromatosis (desmoid tumour)

S Tejpar 1,2, C Li 1, C Yu 1, R Poon 1, H Denys 2, R Sciot 3, E Van Cutsem 4, J J Cassiman 2, B A Alman 1,5
PMCID: PMC2363921  PMID: 11437409

Abstract

Aggressive fibromatosis harbours mutations resulting in β-catenin protein stabilization. Primary cell cultures demonstrate constitutive tcf activation in aggressive fibromatosis. Expression and co-immunoprecipitation studies suggest that β-catenin binds and activates tcf-3 in this tumour. This is the first demonstration of tcf-3 activation by β-catenin stabilization in a human neoplastic process. © 2001 Cancer Research Campaign http://www.bjcancer.com

Keywords: β-catenin, tcf/lef transcription factors, aggressive fibromatosis, APC

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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