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. 2001 Nov;85(10):1535–1539. doi: 10.1054/bjoc.2001.2088

SYT-SSX fusion genes and prognosis in synovial sarcoma

A Mezzelani 1, L Mariani 2, E Tamborini 1, V Agus 1, C Riva 1, S Lo Vullo 2, A Fabbri 1, M Stumbo 1, A Azzarelli 3, P G Casali 4, A Gronchi 3, G Sozzi 5, M A Pierotti 5, S Pilotti 1
PMCID: PMC2363950  PMID: 11720441

Abstract

A case series of 64 synovial sarcomas was characterized for the SYT-SSX fusion transcripts and statistically analysed in order to correlate molecular data with prognosis and morphology. SYT-SSX1 fusion transcript appeared to be an independent, though not reaching statistical significance (P = 0.183), prognostic factor clearly associated with a reduced metastasis-free survival. Regarding the association between transcript type and histologic subtype we found, a borderline P value (P = 0.067) between the SYT-SSX1 transcript and the biphasic subtype which, subsequently expanding the analysis to 70 cases, turned out to be significant. However, we could not confirm the prediction value of the biphasic subtype for the presence of the SYT-SSX1 transcript since in our hands 6 out 33 (18%) biphasic tumours carried the SYT-SSX2 transcript.© 2001 Cancer Research Campaign  http://www.bjcancer.com

Keywords: synovial sarcoma, fusion transcripts, morphology, prognosis

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Selected References

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