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. 2001 Dec;85(12):1964–1967. doi: 10.1054/bjoc.2001.2188

Topical administration of a doxorubicin-specific monoclonal antibody prevents drug-induced mouth apoptosis in mice

A Balsari 1, C Rumio 2, D Morelli 3, L Sfondrini 3, E Nardini 3, I Barajon 1, S Ménard 3
PMCID: PMC2364005  PMID: 11747341

Abstract

One of the most severe side effects of anti-tumour chemotherapy is mucositis due to drug toxicity for rapidly dividing cells. We show here that anti-DXR monoclonal antibodies can prevent DXR-induced damage. Indeed, apoptosis, confined to the proliferative compartment of the basal mucosa, observed in the tongue of DXR-treated mice was completely inhibited by topical application of the anti-DXR antibodies. © 2001 Cancer Research Campaign http://www.bjcancer.com

Keywords: mucositis, doxorubicin, monoclonal antibody, apoptosis, antidotal activity

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Selected References

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