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. 2001 Sep;85(5):678–682. doi: 10.1054/bjoc.2001.1986

Risk of cancers of the lung, head and neck in patients hospitalized for alcoholism in Sweden

P Boffetta 1,2, W Ye 2, H-O Adami 2,3, L A Mucci 3, O Nyrén 2
PMCID: PMC2364115  PMID: 11531251

Abstract

Alcoholic patients are at increased risk of cancers of the head and neck but little information is available on the magnitude of the risk for specific sites and for different histological types. We followed 182 667 patients with a hospital discharge diagnosis of alcoholism during 1965–1994, for an average of 10.2 years. We compared their incidence of site- and histological type-specific cancers of the oral cavity, pharynx, larynx and lung with that of the national population. The standardized incidence ratio (SIR) of cancer of the oral cavity and pharynx was 5.33 (95% confidence interval [CI] 5.04–5.64, based on 1207 cases). The SIRs of laryngeal and lung cancer were 4.21 (95% Cl 3.78–4.68, 347 cases) and 2.40 (2.29–2.51, 1880 cases), respectively. The SIR was highest for cancers of the hypopharynx, floor of the mouth, mesopharynx and base of the tongue. The relative excess of lung cancer was similar for squamous cell carcinoma and adenocarcinoma. Low age at first hospitalization was associated with higher SIRs for all sites under study. 25 years after first hospitalization for alcoholism, the cumulative probability of developing a lung cancer was in the order of 5%, for oral and pharyngeal cancer it was 2.5%, and for oesophageal or laryngeal cancer 1% each. Our study shows that the risk of head and neck cancer among heavy drinkers is highest for sites in direct contact with alcohol. The high risk of head and neck neoplasms may justify specific medical attention. © 2001 Cancer Research Campaign http://www.bjcancer.com

Keywords: alcohol, laryngeal neoplasms, lung neoplasms, oral cavity neoplasms

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Selected References

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  1. Adami H. O., McLaughlin J. K., Hsing A. W., Wolk A., Ekbom A., Holmberg L., Persson I. Alcoholism and cancer risk: a population-based cohort study. Cancer Causes Control. 1992 Sep;3(5):419–425. doi: 10.1007/BF00051354. [DOI] [PubMed] [Google Scholar]
  2. Boffetta P., Mashberg A., Winkelmann R., Garfinkel L. Carcinogenic effect of tobacco smoking and alcohol drinking on anatomic sites of the oral cavity and oropharynx. Int J Cancer. 1992 Oct 21;52(4):530–533. doi: 10.1002/ijc.2910520405. [DOI] [PubMed] [Google Scholar]
  3. Franceschi S., Barra S., La Vecchia C., Bidoli E., Negri E., Talamini R. Risk factors for cancer of the tongue and the mouth. A case-control study from northern Italy. Cancer. 1992 Nov 1;70(9):2227–2233. doi: 10.1002/1097-0142(19921101)70:9<2227::aid-cncr2820700902>3.0.co;2-z. [DOI] [PubMed] [Google Scholar]
  4. Hakulinen T., Lehtimäki L., Lehtonen M., Teppo L. Cancer morbidity among two male cohorts with increased alcohol consumption in Finland. J Natl Cancer Inst. 1974 Jun;52(6):1711–1714. doi: 10.1093/jnci/52.6.1711. [DOI] [PubMed] [Google Scholar]
  5. Kjaerheim K., Gaard M., Andersen A. The role of alcohol, tobacco, and dietary factors in upper aerogastric tract cancers: a prospective study of 10,900 Norwegian men. Cancer Causes Control. 1998 Jan;9(1):99–108. doi: 10.1023/a:1008809706062. [DOI] [PubMed] [Google Scholar]
  6. Lagiou P., Ye W., Wedrén S., Ekbom A., Nyrén O., Trichopoulos D., Adami H. O. Incidence of ovarian cancer among alcoholic women: a cohort study in Sweden. Int J Cancer. 2001 Jan 15;91(2):264–266. doi: 10.1002/1097-0215(200002)9999:9999<::aid-ijc1027>3.3.co;2-b. [DOI] [PubMed] [Google Scholar]
  7. Muscat J. E., Wynder E. L. A case/control study of risk factors for major salivary gland cancer. Otolaryngol Head Neck Surg. 1998 Feb;118(2):195–198. doi: 10.1016/S0194-5998(98)80013-2. [DOI] [PubMed] [Google Scholar]
  8. Nam J. M., McLaughlin J. K., Blot W. J. Cigarette smoking, alcohol, and nasopharyngeal carcinoma: a case-control study among U.S. whites. J Natl Cancer Inst. 1992 Apr 15;84(8):619–622. doi: 10.1093/jnci/84.8.619. [DOI] [PubMed] [Google Scholar]
  9. Pell S., D'Alonzo C. A. A five-year mortality study of alcoholics. J Occup Med. 1973 Feb;15(2):120–125. [PubMed] [Google Scholar]
  10. Prior P. Long-term cancer risk in alcoholism. Alcohol Alcohol. 1988;23(2):163–171. [PubMed] [Google Scholar]
  11. Robinette C. D., Hrubec Z., Fraumeni J. F., Jr Chronic alcoholism and subsequent mortality in World War II veterans. Am J Epidemiol. 1979 Jun;109(6):687–700. doi: 10.1093/oxfordjournals.aje.a112732. [DOI] [PubMed] [Google Scholar]
  12. Schmidt W., Popham R. E. The role of drinking and smoking in mortality from cancer and other causes in male alcoholics. Cancer. 1981 Mar 1;47(5):1031–1041. doi: 10.1002/1097-0142(19810301)47:5<1031::aid-cncr2820470534>3.0.co;2-c. [DOI] [PubMed] [Google Scholar]
  13. Seitz H. K., Pöschl G., Simanowski U. A. Alcohol and cancer. Recent Dev Alcohol. 1998;14:67–95. doi: 10.1007/0-306-47148-5_4. [DOI] [PubMed] [Google Scholar]
  14. Sigvardsson S., Hardell L., Przybeck T. R., Cloninger R. Increased cancer risk among Swedish female alcoholics. Epidemiology. 1996 Mar;7(2):140–143. doi: 10.1097/00001648-199603000-00006. [DOI] [PubMed] [Google Scholar]
  15. Spitz M. R., Fueger J. J., Goepfert H., Newell G. R. Salivary gland cancer. A case-control investigation of risk factors. Arch Otolaryngol Head Neck Surg. 1990 Oct;116(10):1163–1166. doi: 10.1001/archotol.1990.01870100057012. [DOI] [PubMed] [Google Scholar]
  16. Tuyns A. J., Estève J., Raymond L., Berrino F., Benhamou E., Blanchet F., Boffetta P., Crosignani P., del Moral A., Lehmann W. Cancer of the larynx/hypopharynx, tobacco and alcohol: IARC international case-control study in Turin and Varese (Italy), Zaragoza and Navarra (Spain), Geneva (Switzerland) and Calvados (France). Int J Cancer. 1988 Apr 15;41(4):483–491. doi: 10.1002/ijc.2910410403. [DOI] [PubMed] [Google Scholar]
  17. Tønnesen H., Møller H., Andersen J. R., Jensen E., Juel K. Cancer morbidity in alcohol abusers. Br J Cancer. 1994 Feb;69(2):327–332. doi: 10.1038/bjc.1994.59. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Vaughan T. L., Shapiro J. A., Burt R. D., Swanson G. M., Berwick M., Lynch C. F., Lyon J. L. Nasopharyngeal cancer in a low-risk population: defining risk factors by histological type. Cancer Epidemiol Biomarkers Prev. 1996 Aug;5(8):587–593. [PubMed] [Google Scholar]

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