Abstract
Objective: To determine if amoxicillin/clavulanate potassium is effective in the treatment of Chlamydia trachomatis endocervicitis.
Methods: Thirty-two patients with culture-proven endocervical infection were treated with amoxicillin/clavulanate potassium, 500 mg orally 3 times a day for 10 days. Post-treatment endocervical specimens were obtained at 2, 4, and 6 weeks for culture of C. trachomatis. Male partners were treated with doxycycline, 100 mg orally twice daily for 10 days. The couples were provided condoms and asked to use them throughout the duration of the study.
Results: All patients treated with amoxicillin/clavulanate potassium were cured of signs of cervicitis. All were found to be free of C. trachomatis at their follow-up visits.
Conclusions: Amoxicillin/clavulanate potassium is effective in eradicating C. trachomatis.
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Selected References
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- Bowie W. R., Alexander E. R., Holmes K. K. Eradication of Chlamydia trachomatis from the urethras of men with nongonococcal urethritis by treatment with amoxicillin. Sex Transm Dis. 1981 Apr-Jun;8(2):79–81. doi: 10.1097/00007435-198104000-00010. [DOI] [PubMed] [Google Scholar]
- Bowie W. R. In vitro activity of clavulanic acid, amoxicillin, and ticarcillin against Chlamydia trachomatis. Antimicrob Agents Chemother. 1986 Apr;29(4):713–715. doi: 10.1128/aac.29.4.713. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Centers for Disease Control (CDC) 1985 STD Treatment Guidelines. MMWR Suppl. 1985 Oct 18;34(4):75S–108S. [PubMed] [Google Scholar]
- Centers for Disease Control (CDC) Chlamydia trachomatis infections. Policy guidelines for prevention and control. MMWR Suppl. 1985 Aug 23;34(3):53S–74S. [PubMed] [Google Scholar]
- Csángó P. A., Gundersen T., Martinsen I. M. Effect of amoxicillin on simultaneous Chlamydia trachomatis infection in men with gonococcal urethritis: comparison of three dosage regimens. Sex Transm Dis. 1985 Apr-Jun;12(2):93–96. doi: 10.1097/00007435-198504000-00009. [DOI] [PubMed] [Google Scholar]
- Kirshon B., Faro S., Phillips L. E., Pruett K. Correlation of ultrasonography and bacteriology of the endocervix and posterior cul-de-sac of patients with severe pelvic inflammatory disease. Sex Transm Dis. 1988 Apr-Jun;15(2):103–107. doi: 10.1097/00007435-198804000-00007. [DOI] [PubMed] [Google Scholar]
- Martens M. G., Faro S., Maccato M., Riddle G., Hammill H., Wang Y. In Vitro Susceptibility Testing of Clinical Isolates of Chlamydia trachomatis. Infect Dis Obstet Gynecol. 1993;1(1):40–45. doi: 10.1155/S1064744993000109. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Martin D. H., Pastorek J. G., 2nd, Faro S. In-vitro and in-vivo activity of parenterally administered beta-lactam antibiotics against Chlamydia trachomatis. Sex Transm Dis. 1986 Apr-Jun;13(2):81–87. doi: 10.1097/00007435-198604000-00006. [DOI] [PubMed] [Google Scholar]
- Pearlman M. D., Faro S., Riddle G. D., Tortolero G. In vitro synergy of clindamycin and aminoglycosides against Chlamydia trachomatis. Antimicrob Agents Chemother. 1990 Jul;34(7):1399–1401. doi: 10.1128/aac.34.7.1399. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Platt M. S. Neonatal Hemophilus vaginalis (Corynebacterium vaginalis) infection. Clin Pediatr (Phila) 1971 Sep;10(9):513–516. doi: 10.1177/000992287101000907. [DOI] [PubMed] [Google Scholar]
- Sanders L. L., Jr, Harrison H. R., Washington A. E. Treatment of sexually transmitted chlamydial infections. JAMA. 1986 Apr 4;255(13):1750–1756. [PubMed] [Google Scholar]
- Thompson S. E., Washington A. E. Epidemiology of sexually transmitted Chlamydia trachomatis infections. Epidemiol Rev. 1983;5:96–123. doi: 10.1093/oxfordjournals.epirev.a036266. [DOI] [PubMed] [Google Scholar]
- Toomey K. E., Barnes R. C. Treatment of Chlamydia trachomatis genital infection. Rev Infect Dis. 1990 Jul-Aug;12 (Suppl 6):S645–S655. doi: 10.1093/clinids/12.supplement_6.s645. [DOI] [PubMed] [Google Scholar]
- Wølner-Hanssen P., Paavonen J., Kiviat N., Landers D., Sweet R. L., Eschenbach D. A., Holmes K. K. Ambulatory treatment of suspected pelvic inflammatory disease with Augmentin, with or without doxycycline. Am J Obstet Gynecol. 1988 Mar;158(3 Pt 1):577–579. doi: 10.1016/0002-9378(88)90030-0. [DOI] [PubMed] [Google Scholar]