Abstract
Objective: A study was carried out to compare 3 treatment regimens for vaginal candidiasis.
Methods: A total of 150 women with clinical and mycological evidence of vaginal candidiasis were randomized to receive 50 mg of oral fluconazole daily for 6 days (50 women), a single oral 150 mg dose of fluconazole (50 women), or 100 mg of intravaginal clotrimazole daily for 6 days (50 women). They were assessed at 5–15 days (short-term assessment) and again at 30–60 days (long-term assessment) after the completion of treatment.
Results: Candida species were completely eradicated from the vagina in 88% or 80% in the 6-day oral fluconzaole group, 76% or 70% in the single oral fluconazole group, and 72% or 60% in the intravaginal clotrimazole group at short-term or long-term assessment, respectively. The rates of clinical effectiveness were 92% or 88% in the 6-day oral fluconzaole group, 80% or 76% in the single oral fluconazole group, and 72% or 58% in the intravaginal clotrimazole group at the short-term or long-term assessment, respectively. Treatment-related side effects were not found in any group.
Conclusions: This study suggests that the treatment of vaginal candidiasis with oral fluconazole is effective and that a single oral fluconazole dose might be one choice in the treatment of vaginal candidiasis.
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Selected References
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- Bisschop M. P., Merkus J. M., Scheygrond H., Van Cutsem J., van de Kuy A. Treatment of vaginal candidiasis with ketoconazole, a new, orally active, antimycotic. Eur J Obstet Gynecol Reprod Biol. 1979 Aug;9(4):253–259. doi: 10.1016/0028-2243(79)90065-0. [DOI] [PubMed] [Google Scholar]
- Humphrey M. J., Jevons S., Tarbit M. H. Pharmacokinetic evaluation of UK-49,858, a metabolically stable triazole antifungal drug, in animals and humans. Antimicrob Agents Chemother. 1985 Nov;28(5):648–653. doi: 10.1128/aac.28.5.648. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kutzer E., Oittner R., Leodolter S., Brammer K. W. A comparison of fluconazole and ketoconazole in the oral treatment of vaginal candidiasis; report of a double-blind multicentre trial. Eur J Obstet Gynecol Reprod Biol. 1988 Dec;29(4):305–313. doi: 10.1016/0028-2243(88)90071-8. [DOI] [PubMed] [Google Scholar]
- Miles M. R., Olsen L., Rogers A. Recurrent vaginal candidiasis. Importance of an intestinal reservoir. JAMA. 1977 Oct 24;238(17):1836–1837. doi: 10.1001/jama.238.17.1836. [DOI] [PubMed] [Google Scholar]
- O'Connor M. I., Sobel J. D. Epidemiology of recurrent vulvovaginal candidiasis: identification and strain differentiation of Candida albicans. J Infect Dis. 1986 Aug;154(2):358–363. doi: 10.1093/infdis/154.2.358. [DOI] [PubMed] [Google Scholar]
- Odds F. C. Genital candidosis. Clin Exp Dermatol. 1982 Jul;7(4):345–354. doi: 10.1111/j.1365-2230.1982.tb02441.x. [DOI] [PubMed] [Google Scholar]
- Phillips R. J., Watson S. A., McKay F. F. An open multicentre study of the efficacy and safety of a single dose of fluconazole 150 mg in the treatment of vaginal candidiasis in general practice. Br J Clin Pract. 1990 Jun;44(6):219–222. [PubMed] [Google Scholar]
- Richardson K., Brammer K. W., Marriott M. S., Troke P. F. Activity of UK-49,858, a bis-triazole derivative, against experimental infections with Candida albicans and Trichophyton mentagrophytes. Antimicrob Agents Chemother. 1985 May;27(5):832–835. doi: 10.1128/aac.27.5.832. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Stein G. E., Christensen S., Mummaw N. Comparative study of fluconazole and clotrimazole in the treatment of vulvovaginal candidiasis. DICP. 1991 Jun;25(6):582–585. doi: 10.1177/106002809102500602. [DOI] [PubMed] [Google Scholar]
- Troke P. F., Andrews R. J., Brammer K. W., Marriott M. S., Richardson K. Efficacy of UK-49,858 (fluconazole) against Candida albicans experimental infections in mice. Antimicrob Agents Chemother. 1985 Dec;28(6):815–818. doi: 10.1128/aac.28.6.815. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Van Tyle J. H. Ketoconazole. Mechanism of action, spectrum of activity, pharmacokinetics, drug interactions, adverse reactions and therapeutic use. Pharmacotherapy. 1984 Nov-Dec;4(6):343–373. doi: 10.1002/j.1875-9114.1984.tb03398.x. [DOI] [PubMed] [Google Scholar]
- Van der Pas H., Peeters F., Janssens D., Snauwaert E., Van Cutsem J. Treatment of vaginal candidosis with oral ketoconazole. Eur J Obstet Gynecol Reprod Biol. 1983 Mar;14(6):399–404. doi: 10.1016/0028-2243(83)90209-5. [DOI] [PubMed] [Google Scholar]