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Infectious Diseases in Obstetrics and Gynecology logoLink to Infectious Diseases in Obstetrics and Gynecology
. 1995;3(6):256–261. doi: 10.1155/S1064744995000755

Lyme Disease and Pregnancy

James M Alexander 1,, Susan M Cox 1
PMCID: PMC2364450  PMID: 18476053

Abstract

Lyme disease is the most commonly transmitted vector-borne disease in the United States, with many regions of the country at risk. Like other spirochete-borne infections, Lyme disease progresses in stages, making diagnosis in the early stages of the illness and prompt treatment important for cure. An early diagnosis is made difficult by the less-than-ideal serologic tests and the varied clinical presentations of the disease. Although Lyme disease has been reported in pregnancy, the transmission rate to the fetus and potential harmful effects are largely unknown. This review discusses the diagnosis, clinical course, and treatment of Lyme disease with an emphasis on the pregnant patient.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Asbrink E., Hovmark A. Early and late cutaneous manifestations in Ixodes-borne borreliosis (erythema migrans borreliosis, Lyme borreliosis). Ann N Y Acad Sci. 1988;539:4–15. doi: 10.1111/j.1749-6632.1988.tb31833.x. [DOI] [PubMed] [Google Scholar]
  2. Burgdorfer W., Barbour A. G., Hayes S. F., Benach J. L., Grunwaldt E., Davis J. P. Lyme disease-a tick-borne spirochetosis? Science. 1982 Jun 18;216(4552):1317–1319. doi: 10.1126/science.7043737. [DOI] [PubMed] [Google Scholar]
  3. Craft J. E., Grodzicki R. L., Steere A. C. Antibody response in Lyme disease: evaluation of diagnostic tests. J Infect Dis. 1984 May;149(5):789–795. doi: 10.1093/infdis/149.5.789. [DOI] [PubMed] [Google Scholar]
  4. Dick J. D., Rosengard B. R., Merz W. G., Stuart R. K., Hutchins G. M., Saral R. Fatal disseminated candidiasis due to amphotericin-B-resistant Candida guilliermondii. Ann Intern Med. 1985 Jan;102(1):67–68. doi: 10.7326/0003-4819-102-1-67. [DOI] [PubMed] [Google Scholar]
  5. Hardin J. A., Steere A. C., Malawista S. E. Immune complexes and the evolution of Lyme arthritis. Dissemination and localization of abnormal C1q binding activity. N Engl J Med. 1979 Dec 20;301(25):1358–1363. doi: 10.1056/NEJM197912203012502. [DOI] [PubMed] [Google Scholar]
  6. Hedberg C. W., Osterholm M. T., MacDonald K. L., White K. E. An interlaboratory study of antibody to Borrelia burgdorferi. J Infect Dis. 1987 Jun;155(6):1325–1327. doi: 10.1093/infdis/155.6.1325. [DOI] [PubMed] [Google Scholar]
  7. MacDonald A. B., Benach J. L., Burgdorfer W. Stillbirth following maternal Lyme disease. N Y State J Med. 1987 Nov;87(11):615–616. [PubMed] [Google Scholar]
  8. Magnarelli L. A., Meegan J. M., Anderson J. F., Chappell W. A. Comparison of an indirect fluorescent-antibody test with an enzyme-linked immunosorbent assay for serological studies of Lyme disease. J Clin Microbiol. 1984 Aug;20(2):181–184. doi: 10.1128/jcm.20.2.181-184.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Markowitz L. E., Steere A. C., Benach J. L., Slade J. D., Broome C. V. Lyme disease during pregnancy. JAMA. 1986 Jun 27;255(24):3394–3396. [PubMed] [Google Scholar]
  10. Markowitz L. E., Steere A. C., Benach J. L., Slade J. D., Broome C. V. Lyme disease during pregnancy. JAMA. 1986 Jun 27;255(24):3394–3396. [PubMed] [Google Scholar]
  11. Nadal D., Hunziker U. A., Bucher H. U., Hitzig W. H., Duc G. Infants born to mothers with antibodies against Borrelia burgdorferi at delivery. Eur J Pediatr. 1989 Feb;148(5):426–427. doi: 10.1007/BF00595903. [DOI] [PubMed] [Google Scholar]
  12. Pachner A. R., Steere A. C. The triad of neurologic manifestations of Lyme disease: meningitis, cranial neuritis, and radiculoneuritis. Neurology. 1985 Jan;35(1):47–53. doi: 10.1212/wnl.35.1.47. [DOI] [PubMed] [Google Scholar]
  13. Reik L., Steere A. C., Bartenhagen N. H., Shope R. E., Malawista S. E. Neurologic abnormalities of Lyme disease. Medicine (Baltimore) 1979 Jul;58(4):281–294. doi: 10.1097/00005792-197907000-00001. [DOI] [PubMed] [Google Scholar]
  14. Schlesinger P. A., Duray P. H., Burke B. A., Steere A. C., Stillman M. T. Maternal-fetal transmission of the Lyme disease spirochete, Borrelia burgdorferi. Ann Intern Med. 1985 Jul;103(1):67–68. doi: 10.7326/0003-4819-103-1-67. [DOI] [PubMed] [Google Scholar]
  15. Stafford K. C., 3rd Lyme disease prevention: personal protection and prospects for tick control. Conn Med. 1989 Jun;53(6):347–351. [PubMed] [Google Scholar]
  16. Stanek G., Pletschette M., Flamm H., Hirschl A. M., Aberer E., Kristoferitsch W., Schmutzhard E. European Lyme borreliosis. Ann N Y Acad Sci. 1988;539:274–282. doi: 10.1111/j.1749-6632.1988.tb31861.x. [DOI] [PubMed] [Google Scholar]
  17. Steere A. C., Bartenhagen N. H., Craft J. E., Hutchinson G. J., Newman J. H., Rahn D. W., Sigal L. H., Spieler P. N., Stenn K. S., Malawista S. E. The early clinical manifestations of Lyme disease. Ann Intern Med. 1983 Jul;99(1):76–82. doi: 10.7326/0003-4819-99-1-76. [DOI] [PubMed] [Google Scholar]
  18. Steere A. C., Batsford W. P., Weinberg M., Alexander J., Berger H. J., Wolfson S., Malawista S. E. Lyme carditis: cardiac abnormalities of Lyme disease. Ann Intern Med. 1980 Jul;93(1):8–16. doi: 10.7326/0003-4819-93-1-8. [DOI] [PubMed] [Google Scholar]
  19. Steere A. C., Green J., Schoen R. T., Taylor E., Hutchinson G. J., Rahn D. W., Malawista S. E. Successful parenteral penicillin therapy of established Lyme arthritis. N Engl J Med. 1985 Apr 4;312(14):869–874. doi: 10.1056/NEJM198504043121401. [DOI] [PubMed] [Google Scholar]
  20. Steere A. C., Hutchinson G. J., Rahn D. W., Sigal L. H., Craft J. E., DeSanna E. T., Malawista S. E. Treatment of the early manifestations of Lyme disease. Ann Intern Med. 1983 Jul;99(1):22–26. doi: 10.7326/0003-4819-99-1-22. [DOI] [PubMed] [Google Scholar]
  21. Steere A. C. Lyme disease. N Engl J Med. 1989 Aug 31;321(9):586–596. doi: 10.1056/NEJM198908313210906. [DOI] [PubMed] [Google Scholar]
  22. Steere A. C., Malawista S. E. Cases of Lyme disease in the United States: locations correlated with distribution of Ixodes dammini. Ann Intern Med. 1979 Nov;91(5):730–733. doi: 10.7326/0003-4819-91-5-730. [DOI] [PubMed] [Google Scholar]
  23. Steere A. C., Malawista S. E., Newman J. H., Spieler P. N., Bartenhagen N. H. Antibiotic therapy in Lyme disease. Ann Intern Med. 1980 Jul;93(1):1–8. doi: 10.7326/0003-4819-93-1-1. [DOI] [PubMed] [Google Scholar]
  24. Steere A. C., Malawista S. E., Snydman D. R., Shope R. E., Andiman W. A., Ross M. R., Steele F. M. Lyme arthritis: an epidemic of oligoarticular arthritis in children and adults in three connecticut communities. Arthritis Rheum. 1977 Jan-Feb;20(1):7–17. doi: 10.1002/art.1780200102. [DOI] [PubMed] [Google Scholar]
  25. Steere A. C., Pachner A. R., Malawista S. E. Neurologic abnormalities of Lyme disease: successful treatment with high-dose intravenous penicillin. Ann Intern Med. 1983 Dec;99(6):767–772. doi: 10.7326/0003-4819-99-6-767. [DOI] [PubMed] [Google Scholar]
  26. Steere A. C., Taylor E., Wilson M. L., Levine J. F., Spielman A. Longitudinal assessment of the clinical and epidemiological features of Lyme disease in a defined population. J Infect Dis. 1986 Aug;154(2):295–300. doi: 10.1093/infdis/154.2.295. [DOI] [PubMed] [Google Scholar]
  27. Strobino B. A., Williams C. L., Abid S., Chalson R., Spierling P. Lyme disease and pregnancy outcome: a prospective study of two thousand prenatal patients. Am J Obstet Gynecol. 1993 Aug;169(2 Pt 1):367–374. doi: 10.1016/0002-9378(93)90088-z. [DOI] [PubMed] [Google Scholar]
  28. Tsai T. F., Bailey R. E., Moore P. S. National surveillance of Lyme disease, 1987-1988. Conn Med. 1989 Jun;53(6):324–326. [PubMed] [Google Scholar]
  29. Weber K., Bratzke H. J., Neubert U., Wilske B., Duray P. H. Borrelia burgdorferi in a newborn despite oral penicillin for Lyme borreliosis during pregnancy. Pediatr Infect Dis J. 1988 Apr;7(4):286–289. doi: 10.1097/00006454-198804000-00010. [DOI] [PubMed] [Google Scholar]
  30. Weber K., Bratzke H. J., Neubert U., Wilske B., Duray P. H. Borrelia burgdorferi in a newborn despite oral penicillin for Lyme borreliosis during pregnancy. Pediatr Infect Dis J. 1988 Apr;7(4):286–289. doi: 10.1097/00006454-198804000-00010. [DOI] [PubMed] [Google Scholar]

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