Skip to main content
NCBI home page
Infectious Diseases in Obstetrics and Gynecology logoLink to Infectious Diseases in Obstetrics and Gynecology
. 1996;4(3):117–121. doi: 10.1155/S1064744996000269

Cell Mediated Immunity in Human Pathology: The Importance of Choosing the Right Weapon

Mario Clerici 1,✉, Chiara Vismara 2, Claudia Clerici 3, Maria Luisa Villa 2
PMCID: PMC2364479  PMID: 18476080

Full Text

The Full Text of this article is available as a PDF (434.7 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Blatt S. P., Hendrix C. W., Butzin C. A., Freeman T. M., Ward W. W., Hensley R. E., Melcher G. P., Donovan D. J., Boswell R. N. Delayed-type hypersensitivity skin testing predicts progression to AIDS in HIV-infected patients. Ann Intern Med. 1993 Aug 1;119(3):177–184. doi: 10.7326/0003-4819-119-3-199308010-00001. [DOI] [PubMed] [Google Scholar]
  2. Bost K. L., Bieligk S. C., Jaffe B. M. Lymphokine mRNA expression by transplantable murine B lymphocytic malignancies. Tumor-derived IL-10 as a possible mechanism for modulating the anti-tumor response. J Immunol. 1995 Jan 15;154(2):718–729. [PubMed] [Google Scholar]
  3. Brunda M. J., Luistro L., Warrier R. R., Wright R. B., Hubbard B. R., Murphy M., Wolf S. F., Gately M. K. Antitumor and antimetastatic activity of interleukin 12 against murine tumors. J Exp Med. 1993 Oct 1;178(4):1223–1230. doi: 10.1084/jem.178.4.1223. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Chen Q., Daniel V., Maher D. W., Hersey P. Production of IL-10 by melanoma cells: examination of its role in immunosuppression mediated by melanoma. Int J Cancer. 1994 Mar 1;56(5):755–760. doi: 10.1002/ijc.2910560524. [DOI] [PubMed] [Google Scholar]
  5. Clerici M., Balotta C., Meroni L., Ferrario E., Riva C., Trabattoni D., Ridolfo A., Villa M., Shearer G. M., Moroni M. Type 1 cytokine production and low prevalence of viral isolation correlate with long-term nonprogression in HIV infection. AIDS Res Hum Retroviruses. 1996 Jul 20;12(11):1053–1061. doi: 10.1089/aid.1996.12.1053. [DOI] [PubMed] [Google Scholar]
  6. Clerici M. Cell-mediated immunity in HIV infection. AIDS. 1993;7 (Suppl 1):S135–S140. [PubMed] [Google Scholar]
  7. Clerici M., Ferrario E., Trabattoni D., Viviani S., Bonfanti V., Venzon D. J., Clerici E., Shearer G. M., Villa M. L. Multiple defects of T helper cell function in newly diagnosed patients with Hodgkin's disease. Eur J Cancer. 1994;30A(10):1464–1470. doi: 10.1016/0959-8049(94)00305-o. [DOI] [PubMed] [Google Scholar]
  8. Clerici M., Shearer G. M. A TH1-->TH2 switch is a critical step in the etiology of HIV infection. Immunol Today. 1993 Mar;14(3):107–111. doi: 10.1016/0167-5699(93)90208-3. [DOI] [PubMed] [Google Scholar]
  9. Clerici M., Shearer G. M. The Th1-Th2 hypothesis of HIV infection: new insights. Immunol Today. 1994 Dec;15(12):575–581. doi: 10.1016/0167-5699(94)90220-8. [DOI] [PubMed] [Google Scholar]
  10. Clerici M., Stocks N. I., Zajac R. A., Boswell R. N., Lucey D. R., Via C. S., Shearer G. M. Detection of three distinct patterns of T helper cell dysfunction in asymptomatic, human immunodeficiency virus-seropositive patients. Independence of CD4+ cell numbers and clinical staging. J Clin Invest. 1989 Dec;84(6):1892–1899. doi: 10.1172/JCI114376. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Da Silva J. A., Spector T. D. The role of pregnancy in the course and aetiology of rheumatoid arthritis. Clin Rheumatol. 1992 Jun;11(2):189–194. doi: 10.1007/BF02207955. [DOI] [PubMed] [Google Scholar]
  12. Dolan M. J., Clerici M., Blatt S. P., Hendrix C. W., Melcher G. P., Boswell R. N., Freeman T. M., Ward W., Hensley R., Shearer G. M. In vitro T cell function, delayed-type hypersensitivity skin testing, and CD4+ T cell subset phenotyping independently predict survival time in patients infected with human immunodeficiency virus. J Infect Dis. 1995 Jul;172(1):79–87. doi: 10.1093/infdis/172.1.79. [DOI] [PubMed] [Google Scholar]
  13. Dudley D. J. Recurrent pregnancy loss and cytokines. Not as simple as it seems. JAMA. 1995 Jun 28;273(24):1958–1959. [PubMed] [Google Scholar]
  14. Ferenczy A. Epidemiology and clinical pathophysiology of condylomata acuminata. Am J Obstet Gynecol. 1995 Apr;172(4 Pt 2):1331–1339. doi: 10.1016/0002-9378(95)90399-2. [DOI] [PubMed] [Google Scholar]
  15. Gately M. K., Warrier R. R., Honasoge S., Carvajal D. M., Faherty D. A., Connaughton S. E., Anderson T. D., Sarmiento U., Hubbard B. R., Murphy M. Administration of recombinant IL-12 to normal mice enhances cytolytic lymphocyte activity and induces production of IFN-gamma in vivo. Int Immunol. 1994 Jan;6(1):157–167. doi: 10.1093/intimm/6.1.157. [DOI] [PubMed] [Google Scholar]
  16. Hill J. A., Polgar K., Anderson D. J. T-helper 1-type immunity to trophoblast in women with recurrent spontaneous abortion. JAMA. 1995 Jun 28;273(24):1933–1936. [PubMed] [Google Scholar]
  17. Huettner C., Paulus W., Roggendorf W. Messenger RNA expression of the immunosuppressive cytokine IL-10 in human gliomas. Am J Pathol. 1995 Feb;146(2):317–322. [PMC free article] [PubMed] [Google Scholar]
  18. Israël-Biet D., Labrousse F., Tourani J. M., Sors H., Andrieu J. M., Even P. Elevation of IgE in HIV-infected subjects: a marker of poor prognosis. J Allergy Clin Immunol. 1992 Jan;89(1 Pt 1):68–75. doi: 10.1016/s0091-6749(05)80042-9. [DOI] [PubMed] [Google Scholar]
  19. Kaufmann S. H. Immunity to intracellular bacteria. Annu Rev Immunol. 1993;11:129–163. doi: 10.1146/annurev.iy.11.040193.001021. [DOI] [PubMed] [Google Scholar]
  20. Kim J., Modlin R. L., Moy R. L., Dubinett S. M., McHugh T., Nickoloff B. J., Uyemura K. IL-10 production in cutaneous basal and squamous cell carcinomas. A mechanism for evading the local T cell immune response. J Immunol. 1995 Aug 15;155(4):2240–2247. [PubMed] [Google Scholar]
  21. Lafferty K. J., Prowse S. J., Simeonovic C. J., Warren H. S. Immunobiology of tissue transplantation: a return to the passenger leukocyte concept. Annu Rev Immunol. 1983;1:143–173. doi: 10.1146/annurev.iy.01.040183.001043. [DOI] [PubMed] [Google Scholar]
  22. Lane H. C., Depper J. M., Greene W. C., Whalen G., Waldmann T. A., Fauci A. S. Qualitative analysis of immune function in patients with the acquired immunodeficiency syndrome. Evidence for a selective defect in soluble antigen recognition. N Engl J Med. 1985 Jul 11;313(2):79–84. doi: 10.1056/NEJM198507113130204. [DOI] [PubMed] [Google Scholar]
  23. Levy J. A. HIV pathogenesis and long-term survival. AIDS. 1993 Nov;7(11):1401–1410. doi: 10.1097/00002030-199311000-00001. [DOI] [PubMed] [Google Scholar]
  24. Levy J. A. Pathogenesis of human immunodeficiency virus infection. Microbiol Rev. 1993 Mar;57(1):183–289. doi: 10.1128/mr.57.1.183-289.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Lorincz A. T., Reid R., Jenson A. B., Greenberg M. D., Lancaster W., Kurman R. J. Human papillomavirus infection of the cervix: relative risk associations of 15 common anogenital types. Obstet Gynecol. 1992 Mar;79(3):328–337. doi: 10.1097/00006250-199203000-00002. [DOI] [PubMed] [Google Scholar]
  26. Lucey D. R., Melcher G. P., Hendrix C. W., Zajac R. A., Goetz D. W., Butzin C. A., Clerici M., Warner R. D., Abbadessa S., Hall K. Human immunodeficiency virus infection in the US Air Force: seroconversions, clinical staging, and assessment of a T helper cell functional assay to predict change in CD4+ T cell counts. J Infect Dis. 1991 Oct;164(4):631–637. doi: 10.1093/infdis/164.4.631. [DOI] [PubMed] [Google Scholar]
  27. Maeurer M. J., Martin D. M., Castelli C., Elder E., Leder G., Storkus W. J., Lotze M. T. Host immune response in renal cell cancer: interleukin-4 (IL-4) and IL-10 mRNA are frequently detected in freshly collected tumor-infiltrating lymphocytes. Cancer Immunol Immunother. 1995 Aug;41(2):111–121. doi: 10.1007/BF01527407. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Marzi M., Vigano A., Trabattoni D., Villa M. L., Salvaggio A., Clerici E., Clerici M. Characterization of type 1 and type 2 cytokine production profile in physiologic and pathologic human pregnancy. Clin Exp Immunol. 1996 Oct;106(1):127–133. doi: 10.1046/j.1365-2249.1996.d01-809.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Moghe M. V., Advani S. H., Gangal S. G. Demonstration of inhibitory factors affecting cell-mediated immunity in patients with Hodgkin's disease. Eur J Cancer. 1980 Jul;16(7):937–943. doi: 10.1016/0014-2964(80)90332-1. [DOI] [PubMed] [Google Scholar]
  30. Mosmann T. R., Coffman R. L. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol. 1989;7:145–173. doi: 10.1146/annurev.iy.07.040189.001045. [DOI] [PubMed] [Google Scholar]
  31. Nossent H. C., Swaak T. J. Systemic lupus erythematosus. VI. Analysis of the interrelationship with pregnancy. J Rheumatol. 1990 Jun;17(6):771–776. [PubMed] [Google Scholar]
  32. Romagnani S. Human TH1 and TH2 subsets: doubt no more. Immunol Today. 1991 Aug;12(8):256–257. doi: 10.1016/0167-5699(91)90120-I. [DOI] [PubMed] [Google Scholar]
  33. Smith D. R., Kunkel S. L., Burdick M. D., Wilke C. A., Orringer M. B., Whyte R. I., Strieter R. M. Production of interleukin-10 by human bronchogenic carcinoma. Am J Pathol. 1994 Jul;145(1):18–25. [PMC free article] [PubMed] [Google Scholar]
  34. Smith K. J., Skelton H. G., Drabick J. J., McCarthy W. F., Ledsky R., Wagner K. F. Hypereosinophilia secondary to immunodysregulation in patients with HIV-1 disease. Arch Dermatol. 1994 Jan;130(1):119–121. doi: 10.1001/archderm.130.1.119. [DOI] [PubMed] [Google Scholar]
  35. Smolen J. S., Bettelheim P., Köller U., McDougal S., Graninger W., Luger T. A., Knapp W., Lechner K. Deficiency of the autologous mixed lymphocyte reaction in patients with classic hemophilia treated with commercial factor VIII concentrate. Correlation with T cell subset distribution, antibodies to lymphadenopathy-associated or human T lymphotropic virus, and analysis of the cellular basis of the deficiency. J Clin Invest. 1985 Jun;75(6):1828–1834. doi: 10.1172/JCI111896. [DOI] [PMC free article] [PubMed] [Google Scholar]
  36. Soulillou J. P., Douillard J. Y., Vie H., Harousseau J. L., Guenel J., le Mevel-le Pourhiet A., le Mevel B. Defect in lectin-induced interleukin 2 (IL-2) production by peripheral blood lymphocytes of patients with Hodgkin's disease. Eur J Cancer Clin Oncol. 1985 Aug;21(8):935–939. doi: 10.1016/0277-5379(85)90111-7. [DOI] [PubMed] [Google Scholar]
  37. Tahara H., Zitvogel L., Storkus W. J., Zeh H. J., 3rd, McKinney T. G., Schreiber R. D., Gubler U., Robbins P. D., Lotze M. T. Effective eradication of established murine tumors with IL-12 gene therapy using a polycistronic retroviral vector. J Immunol. 1995 Jun 15;154(12):6466–6474. [PubMed] [Google Scholar]
  38. Trinchieri G. Biology of natural killer cells. Adv Immunol. 1989;47:187–376. doi: 10.1016/S0065-2776(08)60664-1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  39. Via C. S., Tsokos G. C., Stocks N. I., Clerici M., Shearer G. M. Human in vitro allogeneic responses. Demonstration of three pathways of T helper cell activation. J Immunol. 1990 Apr 1;144(7):2524–2528. [PubMed] [Google Scholar]
  40. Wegmann T. G., Lin H., Guilbert L., Mosmann T. R. Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a TH2 phenomenon? Immunol Today. 1993 Jul;14(7):353–356. doi: 10.1016/0167-5699(93)90235-D. [DOI] [PubMed] [Google Scholar]
  41. Wright T. C., Jr, Richart R. M. Role of human papillomavirus in the pathogenesis of genital tract warts and cancer. Gynecol Oncol. 1990 May;37(2):151–164. doi: 10.1016/0090-8258(90)90327-h. [DOI] [PubMed] [Google Scholar]
  42. Young R. C., Corder M. P., Haynes H. A., DeVita V. T. Delayed hypersensitivity in Hodgkin's disease. A study of 103 untreated patients. Am J Med. 1972 Jan;52(1):63–72. doi: 10.1016/0002-9343(72)90008-3. [DOI] [PubMed] [Google Scholar]

Articles from Infectious Diseases in Obstetrics and Gynecology are provided here courtesy of Wiley

RESOURCES