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. 1996;4(4):247–254. doi: 10.1155/S1064744996000476

New Treatments for Vulvovaginal Candidiasis

Sebastian Faro 1,
PMCID: PMC2364495  PMID: 18476101

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. A comparison of single-dose oral fluconazole with 3-day intravaginal clotrimazole in the treatment of vaginal candidiasis. Report of an international multicentre trial. Br J Obstet Gynaecol. 1989 Feb;96(2):226–232. doi: 10.1111/j.1471-0528.1989.tb01667.x. [DOI] [PubMed] [Google Scholar]
  2. Apseloff G., Hilligoss D. M., Gardner M. J., Henry E. B., Inskeep P. B., Gerber N., Lazar J. D. Induction of fluconazole metabolism by rifampin: in vivo study in humans. J Clin Pharmacol. 1991 Apr;31(4):358–361. doi: 10.1002/j.1552-4604.1991.tb03718.x. [DOI] [PubMed] [Google Scholar]
  3. Arévalo M. P., Arias A., Andreu A., Rodríguez C., Sierra A. Fluconazole, itraconazole and ketoconazole in vitro activity against Candida spp. J Chemother. 1994 Aug;6(4):226–229. doi: 10.1080/1120009x.1994.11741156. [DOI] [PubMed] [Google Scholar]
  4. Auger P., Joly J. Microbial flora associated with Candida albicans vulvovaginitis. Obstet Gynecol. 1980 Mar;55(3):397–401. doi: 10.1097/00006250-198003000-00029. [DOI] [PubMed] [Google Scholar]
  5. Back D. J., Tjia J. F. Comparative effects of the antimycotic drugs ketoconazole, fluconazole, itraconazole and terbinafine on the metabolism of cyclosporin by human liver microsomes. Br J Clin Pharmacol. 1991 Nov;32(5):624–626. doi: 10.1111/j.1365-2125.1991.tb03963.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Blum R. A., Wilton J. H., Hilligoss D. M., Gardner M. J., Henry E. B., Harrison N. J., Schentag J. J. Effect of fluconazole on the disposition of phenytoin. Clin Pharmacol Ther. 1991 Apr;49(4):420–425. doi: 10.1038/clpt.1991.49. [DOI] [PubMed] [Google Scholar]
  7. Boag F. C., Houang E. T., Westrom R., McCormack S. M., Lawrence A. G. Comparison of vaginal flora after treatment with a clotrimazole 500 mg vaginal pessary or a fluconazole 150 mg capsule for vaginal candidosis. Genitourin Med. 1991 Jun;67(3):232–234. doi: 10.1136/sti.67.3.232. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Bonatz G., Hansmann M. L., Buchholz F., Mettler L., Radzun H. J., Semm K. Macrophage- and lymphocyte-subtypes in the endometrium during different phases of the ovarian cycle. Int J Gynaecol Obstet. 1992 Jan;37(1):29–36. doi: 10.1016/0020-7292(92)90974-n. [DOI] [PubMed] [Google Scholar]
  9. Brammer K. W., Feczko J. M. Single-dose oral fluconazole in the treatment of vaginal candidosis. Ann N Y Acad Sci. 1988;544:561–563. doi: 10.1111/j.1749-6632.1988.tb40452.x. [DOI] [PubMed] [Google Scholar]
  10. Cadle R. M., Zenon G. J., 3rd, Rodriguez-Barradas M. C., Hamill R. J. Fluconazole-induced symptomatic phenytoin toxicity. Ann Pharmacother. 1994 Feb;28(2):191–195. doi: 10.1177/106002809402800206. [DOI] [PubMed] [Google Scholar]
  11. Corson S. L., Kapikian R. R., Nehring R. Terconazole and miconazole cream for treating vulvovaginal candidiasis. A comparison. J Reprod Med. 1991 Aug;36(8):561–567. [PubMed] [Google Scholar]
  12. Davidson F. Yeasts and circumcision in the male. Br J Vener Dis. 1977 Apr;53(2):121–122. doi: 10.1136/sti.53.2.121. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Drake T. E., Maibach H. I. Candida and candidiasis. 1. Cultural conditions, epidemiology and pathogenesis. Postgrad Med. 1973 Feb;53(2):83–87. doi: 10.1080/00325481.1973.11713368. [DOI] [PubMed] [Google Scholar]
  14. Faro S. Vaginitis: diagnosis and management. Int J Fertil Menopausal Stud. 1996 Mar-Apr;41(2):115–123. [PubMed] [Google Scholar]
  15. Fleury F. J. Adult vaginitis. Clin Obstet Gynecol. 1981 Jun;24(2):407–438. doi: 10.1097/00003081-198106000-00008. [DOI] [PubMed] [Google Scholar]
  16. Fong I. W. The value of chronic suppressive therapy with itraconazole versus clotrimazole in women with recurrent vaginal candidiasis. Genitourin Med. 1992 Dec;68(6):374–377. doi: 10.1136/sti.68.6.374. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Gericke K. R. Possible interaction between warfarin and fluconazole. Pharmacotherapy. 1993 Sep-Oct;13(5):508–509. [PubMed] [Google Scholar]
  18. Goldacre M. J., Milne L. J., Watt B., Loudon N., Vessey M. P. Prevalence of Yeast and fungi other than Candida albicans in the vagina of normal young women. Br J Obstet Gynaecol. 1981 Jun;88(6):596–600. doi: 10.1111/j.1471-0528.1981.tb01214.x. [DOI] [PubMed] [Google Scholar]
  19. Grant S. M., Clissold S. P. Fluconazole. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in superficial and systemic mycoses. Drugs. 1990 Jun;39(6):877–916. doi: 10.2165/00003495-199039060-00006. [DOI] [PubMed] [Google Scholar]
  20. Horowitz B. J., Edelstein S. W., Lippman L. Candida tropicalis vulvovaginitis. Obstet Gynecol. 1985 Aug;66(2):229–232. [PubMed] [Google Scholar]
  21. Horowitz B. J., Giaquinta D., Ito S. Evolving pathogens in vulvovaginal candidiasis: implications for patient care. J Clin Pharmacol. 1992 Mar;32(3):248–255. doi: 10.1002/j.1552-4604.1992.tb03833.x. [DOI] [PubMed] [Google Scholar]
  22. Horowitz B. J. Mycotic vulvovaginitis: a broad overview. Am J Obstet Gynecol. 1991 Oct;165(4 Pt 2):1188–1192. doi: 10.1016/s0002-9378(12)90725-5. [DOI] [PubMed] [Google Scholar]
  23. Houang E. T., Chappatte O., Byrne D., Macrae P. V., Thorpe J. E. Fluconazole levels in plasma and vaginal secretions of patients after a 150-milligram single oral dose and rate of eradication of infection in vaginal candidiasis. Antimicrob Agents Chemother. 1990 May;34(5):909–910. doi: 10.1128/aac.34.5.909. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Howitt K. M., Oziemski M. A. Phenytoin toxicity induced by fluconazole. Med J Aust. 1989 Nov 20;151(10):603–604. doi: 10.5694/j.1326-5377.1989.tb101301.x. [DOI] [PubMed] [Google Scholar]
  25. Inman W., Pearce G., Wilton L. Safety of fluconazole in the treatment of vaginal candidiasis. A prescription-event monitoring study, with special reference to the outcome of pregnancy. Eur J Clin Pharmacol. 1994;46(2):115–118. doi: 10.1007/BF00199872. [DOI] [PubMed] [Google Scholar]
  26. Kutzer E., Oittner R., Leodolter S., Brammer K. W. A comparison of fluconazole and ketoconazole in the oral treatment of vaginal candidiasis; report of a double-blind multicentre trial. Eur J Obstet Gynecol Reprod Biol. 1988 Dec;29(4):305–313. doi: 10.1016/0028-2243(88)90071-8. [DOI] [PubMed] [Google Scholar]
  27. Lazar J. D., Wilner K. D. Drug interactions with fluconazole. Rev Infect Dis. 1990 Mar-Apr;12 (Suppl 3):S327–S333. doi: 10.1093/clinids/12.supplement_3.s327. [DOI] [PubMed] [Google Scholar]
  28. López-Gil J. A. Fluconazole-cyclosporine interaction: a dose-dependent effect? Ann Pharmacother. 1993 Apr;27(4):427–430. doi: 10.1177/106002809302700405. [DOI] [PubMed] [Google Scholar]
  29. Mathur S., Melchers J. T., 3rd, Ades E. W., Williamson H. O., Fudenberg H. H. Anti-ovarian and anti-lymphocyte antibodies in patients with chronic vaginal candidiasis. J Reprod Immunol. 1980 Dec;2(5):247–262. doi: 10.1016/0165-0378(80)90038-8. [DOI] [PubMed] [Google Scholar]
  30. O'Connor M. I., Sobel J. D. Epidemiology of recurrent vulvovaginal candidiasis: identification and strain differentiation of Candida albicans. J Infect Dis. 1986 Aug;154(2):358–363. doi: 10.1093/infdis/154.2.358. [DOI] [PubMed] [Google Scholar]
  31. Osser S., Haglund A., Weström L. Treatment of candidal vaginitis. A prospective randomized investigator-blind multicenter study comparing topically applied econazole with oral fluconazole. Acta Obstet Gynecol Scand. 1991;70(1):73–78. doi: 10.3109/00016349109006182. [DOI] [PubMed] [Google Scholar]
  32. Perfect J. R., Lindsay M. H., Drew R. H. Adverse drug reactions to systemic antifungals. Prevention and management. Drug Saf. 1992 Sep-Oct;7(5):323–363. doi: 10.2165/00002018-199207050-00003. [DOI] [PubMed] [Google Scholar]
  33. Redondo-Lopez V., Lynch M., Schmitt C., Cook R., Sobel J. D. Torulopsis glabrata vaginitis: clinical aspects and susceptibility to antifungal agents. Obstet Gynecol. 1990 Oct;76(4):651–655. [PubMed] [Google Scholar]
  34. Rodin P., Kolator B. Carriage of yeasts on the penis. Br Med J. 1976 May 8;1(6018):1123–1124. doi: 10.1136/bmj.1.6018.1123. [DOI] [PMC free article] [PubMed] [Google Scholar]
  35. Sahai J., Gallicano K., Pakuts A., Cameron D. W. Effect of fluconazole on zidovudine pharmacokinetics in patients infected with human immunodeficiency virus. J Infect Dis. 1994 May;169(5):1103–1107. doi: 10.1093/infdis/169.5.1103. [DOI] [PubMed] [Google Scholar]
  36. Seaton T. L., Celum C. L., Black D. J. Possible potentiation of warfarin by fluconazole. DICP. 1990 Dec;24(12):1177–1178. doi: 10.1177/106002809002401207. [DOI] [PubMed] [Google Scholar]
  37. Smail E. H., Kolotila M. P., Ruggeri R., Diamond R. D. Natural inhibitor from Candida albicans blocks release of azurophil and specific granule contents by chemotactic peptide-stimulated human neutrophils. Infect Immun. 1989 Mar;57(3):689–692. doi: 10.1128/iai.57.3.689-692.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
  38. Sobel J. D., Brooker D., Stein G. E., Thomason J. L., Wermeling D. P., Bradley B., Weinstein L. Single oral dose fluconazole compared with conventional clotrimazole topical therapy of Candida vaginitis. Fluconazole Vaginitis Study Group. Am J Obstet Gynecol. 1995 Apr;172(4 Pt 1):1263–1268. doi: 10.1016/0002-9378(95)91490-0. [DOI] [PubMed] [Google Scholar]
  39. Sobel J. D. Candidal vulvovaginitis. Clin Obstet Gynecol. 1993 Mar;36(1):153–165. doi: 10.1097/00003081-199303000-00021. [DOI] [PubMed] [Google Scholar]
  40. Sobel J. D. Management of recurrent vulvovaginal candidiasis with intermittent ketoconazole prophylaxis. Obstet Gynecol. 1985 Mar;65(3):435–440. [PubMed] [Google Scholar]
  41. Sobel J. D., Myers P. G., Kaye D., Levison M. E. Adherence of Candida albicans to human vaginal and buccal epithelial cells. J Infect Dis. 1981 Jan;143(1):76–82. doi: 10.1093/infdis/143.1.76. [DOI] [PubMed] [Google Scholar]
  42. Sobel J. D. Recurrent vulvovaginal candidiasis. A prospective study of the efficacy of maintenance ketoconazole therapy. N Engl J Med. 1986 Dec 4;315(23):1455–1458. doi: 10.1056/NEJM198612043152305. [DOI] [PubMed] [Google Scholar]
  43. Sobel J. D. Vaginal infections in adult women. Med Clin North Am. 1990 Nov;74(6):1573–1602. doi: 10.1016/s0025-7125(16)30496-5. [DOI] [PubMed] [Google Scholar]
  44. Stein G. E., Christensen S., Mummaw N. Comparative study of fluconazole and clotrimazole in the treatment of vulvovaginal candidiasis. DICP. 1991 Jun;25(6):582–585. doi: 10.1177/106002809102500602. [DOI] [PubMed] [Google Scholar]
  45. Syverson R. E., Buckley H., Gibian J., Ryan G. M., Jr Cellular and humoral immune status in women with chronic Candida vaginitis. Am J Obstet Gynecol. 1979 Jul 15;134(6):624–627. doi: 10.1016/0002-9378(79)90641-0. [DOI] [PubMed] [Google Scholar]
  46. Takada M., Kubota T., Hogaki M., Okawa T., Uchida K., Yamaguchi H. Attributes of microorganisms that contribute to recurrence and intractability of vaginal mycosis. Nihon Sanka Fujinka Gakkai Zasshi. 1986 Jul;38(7):1125–1134. [PubMed] [Google Scholar]
  47. Touchette M. A., Chandrasekar P. H., Milad M. A., Edwards D. J. Contrasting effects of fluconazole and ketoconazole on phenytoin and testosterone disposition in man. Br J Clin Pharmacol. 1992 Jul;34(1):75–78. doi: 10.1111/j.1365-2125.1992.tb04111.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  48. Witkin S. S. Inhibition of Candida-induced lymphocyte proliferation by antibody to Candida albicans. Obstet Gynecol. 1986 Nov;68(5):696–699. [PubMed] [Google Scholar]
  49. Witkin S. S., Yu I. R., Ledger W. J. Inhibition of Candida albicans--induced lymphocyte proliferation by lymphocytes and sera from women with recurrent vaginitis. Am J Obstet Gynecol. 1983 Dec 1;147(7):809–811. doi: 10.1016/0002-9378(83)90044-3. [DOI] [PubMed] [Google Scholar]

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