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. 1994 Aug;68(8):5280–5283. doi: 10.1128/jvi.68.8.5280-5283.1994

Spatial discontinuities in human immunodeficiency virus type 1 quasispecies derived from epidermal Langerhans cells of a patient with AIDS and evidence for double infection.

M Sala 1, G Zambruno 1, J P Vartanian 1, A Marconi 1, U Bertazzoni 1, S Wain-Hobson 1
PMCID: PMC236474  PMID: 7545939

Abstract

A nonhomogeneous spatial distribution of human immunodeficiency virus type 1 quasispecies was observed for epidermal Langerhans cells purified from skin patches taken from a patient with AIDS soon after death. Each patch presented a unique collection of sequences, distinct from those of juxtaposed patches or those derived from the other leg. Infection of Langerhans cells by virus from underlying T cells in the dermis might explain this partition. The analysis revealed the presence of two distinct cocirculating viral strains, indicating double infection.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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