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. 1994 Aug;68(8):5284–5286. doi: 10.1128/jvi.68.8.5284-5286.1994

Cervical antibodies in patients with oral herpes simplex virus type 1 (HSV-1) infection: local anamnestic responses after genital HSV-2 infection.

R Ashley 1, A Wald 1, L Corey 1
PMCID: PMC236475  PMID: 8035526

Abstract

Herpes simplex virus (HSV)-specific immunoglobulin A, immunoglobulin G, and secretory-component-containing immunoglobulins were identified in cervical and salivary secretions from six subjects with oral HSV type 1 (HSV-1) infections. Anamnestic cervical and salivary antibody responses were detected in two HSV-1-seropositive women with newly acquired genital HSV-2 infections. These data implicate the common mucosal immune system in antibody responses to HSV.

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Selected References

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  1. Ashley R. L., Militoni J., Lee F., Nahmias A., Corey L. Comparison of Western blot (immunoblot) and glycoprotein G-specific immunodot enzyme assay for detecting antibodies to herpes simplex virus types 1 and 2 in human sera. J Clin Microbiol. 1988 Apr;26(4):662–667. doi: 10.1128/jcm.26.4.662-667.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Ashley R. L., Militoni J. Use of densitometric analysis for interpreting HSV serologies based on Western blot. J Virol Methods. 1987 Nov;18(2-3):159–168. doi: 10.1016/0166-0934(87)90121-2. [DOI] [PubMed] [Google Scholar]
  3. Ashley R., Cent A., Maggs V., Nahmias A., Corey L. Inability of enzyme immunoassays to discriminate between infections with herpes simplex virus types 1 and 2. Ann Intern Med. 1991 Oct 1;115(7):520–526. doi: 10.7326/0003-4819-115-7-520. [DOI] [PubMed] [Google Scholar]
  4. Breinig M. K., Kingsley L. A., Armstrong J. A., Freeman D. J., Ho M. Epidemiology of genital herpes in Pittsburgh: serologic, sexual, and racial correlates of apparent and inapparent herpes simplex infections. J Infect Dis. 1990 Aug;162(2):299–305. doi: 10.1093/infdis/162.2.299. [DOI] [PubMed] [Google Scholar]
  5. Bryson Y., Dillon M., Bernstein D. I., Radolf J., Zakowski P., Garratty E. Risk of acquisition of genital herpes simplex virus type 2 in sex partners of persons with genital herpes: a prospective couple study. J Infect Dis. 1993 Apr;167(4):942–946. doi: 10.1093/infdis/167.4.942. [DOI] [PubMed] [Google Scholar]
  6. Corey L., Adams H. G., Brown Z. A., Holmes K. K. Genital herpes simplex virus infections: clinical manifestations, course, and complications. Ann Intern Med. 1983 Jun;98(6):958–972. doi: 10.7326/0003-4819-98-6-958. [DOI] [PubMed] [Google Scholar]
  7. Dalessio J., Ashley R. Highly sensitive enhanced chemiluminescence immunodetection method for herpes simplex virus type 2 Western immunoblot. J Clin Microbiol. 1992 Apr;30(4):1005–1007. doi: 10.1128/jcm.30.4.1005-1007.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Koutsky L. A., Ashley R. L., Holmes K. K., Stevens C. E., Critchlow C. W., Kiviat N., Lipinski C. M., Wølner-Hanssen P., Corey L. The frequency of unrecognized type 2 herpes simplex virus infection among women. Implications for the control of genital herpes. Sex Transm Dis. 1990 Apr-Jun;17(2):90–94. doi: 10.1097/00007435-199004000-00009. [DOI] [PubMed] [Google Scholar]
  9. McClung H., Seth P., Rawls W. E. Relative concentrations in human sera of antibodies to cross-reacting and specific antigens of Herpes simplex virus types 1 and 2. Am J Epidemiol. 1976 Aug;104(2):192–201. doi: 10.1093/oxfordjournals.aje.a112289. [DOI] [PubMed] [Google Scholar]
  10. McDermott M. R., Bienenstock J. Evidence for a common mucosal immunologic system. I. Migration of B immunoblasts into intestinal, respiratory, and genital tissues. J Immunol. 1979 May;122(5):1892–1898. [PubMed] [Google Scholar]
  11. Merriman H., Woods S., Winter C., Fahnlander A., Corey L. Secretory IgA antibody in cervicovaginal secretions from women with genital infection due to herpes simplex virus. J Infect Dis. 1984 Apr;149(4):505–510. doi: 10.1093/infdis/149.4.505. [DOI] [PubMed] [Google Scholar]
  12. Mertz G. J., Benedetti J., Ashley R., Selke S. A., Corey L. Risk factors for the sexual transmission of genital herpes. Ann Intern Med. 1992 Feb 1;116(3):197–202. doi: 10.7326/0003-4819-116-3-197. [DOI] [PubMed] [Google Scholar]
  13. Mestecky J. The common mucosal immune system and current strategies for induction of immune responses in external secretions. J Clin Immunol. 1987 Jul;7(4):265–276. doi: 10.1007/BF00915547. [DOI] [PubMed] [Google Scholar]
  14. Mohamed O. A., Ashley R., Goldstein A., McElrath J., Dalessio J., Corey L. Detection of rectal antibodies to HIV-1 by a sensitive chemiluminescent western blot immunodetection method. J Acquir Immune Defic Syndr. 1994 Apr;7(4):375–380. [PubMed] [Google Scholar]
  15. Moldoveanu Z., Novak M., Huang W. Q., Gilley R. M., Staas J. K., Schafer D., Compans R. W., Mestecky J. Oral immunization with influenza virus in biodegradable microspheres. J Infect Dis. 1993 Jan;167(1):84–90. doi: 10.1093/infdis/167.1.84. [DOI] [PubMed] [Google Scholar]
  16. Peterson E., Schmidt O. W., Goldstein L. C., Nowinski R. C., Corey L. Typing of clinical herpes simplex virus isolates with mouse monoclonal antibodies to herpes simplex virus types 1 and 2: comparison with type-specific rabbit antisera and restriction endonuclease analysis of viral DNA. J Clin Microbiol. 1983 Jan;17(1):92–96. doi: 10.1128/jcm.17.1.92-96.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]

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