Skip to main content
Metal-Based Drugs logoLink to Metal-Based Drugs
. 1996;3(2):79–83. doi: 10.1155/MBD.1996.79

Complexes With Biologically Active Ligands. Part 4. Coordination Compounds of Chlorothiazide With Transition Metal Ions Behave as Strong Carbonic Anhydrase Inhibitors

Claudiu T Supuran 1
PMCID: PMC2365006  PMID: 18472800

Abstract

Complexes of the diuretic benzothiadiazine derivative chlorothiazide (6-chloro-7-sulfamoyl- 1,2,4-benzothiadiazine-1,1-dioxide) with V(IV); Fe(II); Co(II); Ni(II); Cu(II), Ag(I) and U(VI) were prepared and characterized by elemental analysis, spectroscopic, thermogravimetric, magnetic and conductimetric measurements. The complexes behave as effective inhibitors for two isozymes (I and II) of carbonic anhydrase (CA).

Full Text

The Full Text of this article is available as a PDF (693.9 KB).


Articles from Metal-Based Drugs are provided here courtesy of Wiley

RESOURCES