Anti-Tumor Activity, In Vitro and In Vivo, of Some Triphenylphosphinegold(I) Thionucleobases

Abstract

The [Ph₃PAu(6-MP)] complex, where 6-MPH is 6-mercaptopurine, is active against the cisplatinresistant cell line, mouse leukaemia L1210/DDP, as is the precursor compound [Ph₃PAuCl], suggesting that the thiolate is not critical for activity. Against the human cell lines, FaDu (squamous cell carcinoma) and SKOV-3 (ovarian carcinoma), both [Ph₃PAu(6-MP)] and [Ph₃PAu(6-TG)], where 6-TGH is 6-thioguanine, were active. [Ph₃PAu(6-MP)] was active against a murine PC6 plasmacytoma, but not as active as cisplatin.

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