In Vitro and In Vivo Behaviour of ¹¹¹In Complexes of TTHA, TTHA-Bis(Butylamide) and TTHA-Bis(Glucamide): Stability, Biodistribution and Excretion Studied by Gamma Imaging

Abstract

Aiming at radiopharmaceutical application, ¹¹¹In₃₊ complexes of the polyaminocarboxylates TTHA, TTHA-bis(butylamide) and TTHA-bis(glucamide) were investigated. The in vitro stability of ¹¹¹In(TTHA)³⁻ and ¹¹¹In(TTHA-bis(butylamide)^- was evaluated by measuring the exchange of ¹¹¹In₃₊ from the complexes to transferrin and the results were compared with those for ¹¹¹In(DTPA)²⁻. We also performed biodistribution studies of the three ¹¹¹In₃₊ complexes by gamma-imaging in Wistar rats and by measuring the radioactivity in their organs. TTHA and its derivatives seem to have similar in vivo biodistribution with prevailing renal excretion.

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