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. 1999;6(2):135–141. doi: 10.1155/MBD.1999.135

Radioprotectant Activity of 5-Diethylsulfonamoylsalicylatocopper(II) in Gamma Irradiated Mice

John A Kuykendall, III 1, Hugh Simmons, III 1, Henry J Irving 1, Mark A Wear 2, Paul G Sorenson 2, Linda G Tipton 1, Kenchasha M Maddox 2, Elsie L Williams 1, Van Anh Pham-Tran 2, Chassie Credit 2, Israt L Chowdhury 1, Shaheen Khan 1, J Brooks Tipton 1, William M Willingham 1, John R J Sorenson 2,✉
PMCID: PMC2365160  PMID: 18475892

Abstract

Survival and changes in mean body mass of whole-body irradiated mice were determined to examine the radioprotectant activity of 5-diethylsulfonamoylsalicylatocopper(II) [Cu(II) (5-DESS)]. One of four groups of 25 female C57BL/6 mice were treated subcutaneously (sc)with 0, 10, 20, 40, 60, 80, 100, or 120 μmol Cu(II)(5- DESS)/kg of body mass 3 hours before exposure to 8.0 Gy, gamma irradiation. In this paradigm, doses of Cu(II)(5- DESS) increased survival up to 92% above vehicle-treated control mice (P = 0.008). Mean body mass determinations revealed that mice treated with 80 to 120 μmol Cu(II)(5-DESS)/kg of body mass exhibited a smaller decrease in body mass than other complex-treated groups. These results support the hypothesis that Cu(II)(5-DESS) is an effective radioprotectant.

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