A Study of the Antitumour Activity of Four Triorganophosphinegold(I) Thiolates: R₃ PAu(SR′), R = Ph, Cy, Et; SR′H = 6-Mercaptopurine and R = Et; SR′H = 6-Thioguanine

Abstract

The antitumour activities of four triorganophosphinegold(I) thiolates, R₂PAu(S′R) [R = Ph, Cy, Et; SR′H = 6-mercaptopurine and R Et; SR′H = 6-thioguanine] against the National Cancer Institute (NCI) panel of 60 cell lines are reported The [Cy₃PAu(6-MP)] complex proved to be the more cytotoxic of the four complexes tested. For the 6-MP series, an order of cytotoxicity was established such that the activity followed the order R = Cy > Ph > Et. Sub-panel selectivity against the Leukemia cell lines was found for each of [Cy₃ PAu(6-MP)] and [Et₃PAu(6-TG)].

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