Synthesis, In vitro Antifungal and Antitumour Activity of Some Triorganotin(IV) N,C,N-Chelates

Abstract

The in vitro antifungal activity of compounds 1-3 ($\left\{{\left[{\left({\text{CH}}_3\right)}_2{\text{NCH}}_2\right]}_2{\text{C}}_6{\text{H}}_3\right\}$ ${\text{R}}_2\text{SnX}$; (where X=Cl, R=n-Bu for 1, X=Br, R=n-Bu for 2 and x=${\text{PF}}_6$, R=n=Bu for 3)) was estimated with the help of a modified microdilution format of the M27-A guidelines and was compared with in vitro activity of their diphenyltin(IV) analogues 4 and 5 (where X=Br, R=Ph for 4 and X=${\text{PF}}_6$, R=Ph for 5), and of drugs currently in clinical use (ketoconazole, fluconazole and amphotericin B). It was found that in coordinating solvents the more soluble derivative 2 is less active than the phenyl one (4), and compounds 1 and 3 are even inactive.

In this paper, the in vitro antitumour activity of ionic diphenyltin(IV) complexes 4 and 5 against seven tumoural cell lines of human origin is also reported. The preparation and characterization (${}^1\text{H}$, ${}^{13}\text{C}$ and ${}^{119}\text{Sn}$ NMR spectroscopy and electrospray ionization mass spectrometry) of the novel compound 3 is mentioned too.

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