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. 1992;1(1):5–8. doi: 10.1155/S0962935192000024

Cytokine gene regulation by PGE2, LTB4 and PAF

M Rola-Pleszczynski 1,✉, J Stankova 1
PMCID: PMC2365316  PMID: 18475433

Abstract

The initial response of the host to noxious stimuli produces a nonspecific inflammatory response. A more specific immune response is believed to be modulated by two classes of molecules: lipid mediators (PG, LT and PAF) and cytokines, synthesized by phagocytes and parenchyreal cells. In this review we discuss the increasing evidence of the interrelationship between eicosanoids, PAF and cytokines: IL-1 and TNF induce PG synthesis in various cells and PG, in turn, modulate cytokine production. We focused on the regulatory effects of LTB 4, PGE 2 and PAF on cytokine gene expression.

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Selected References

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