Skip to main content
NCBI home page
Mediators of Inflammation logoLink to Mediators of Inflammation
. 1992;1(1):15–21. doi: 10.1155/S0962935192000048

Foetal vascular responses to thromboxane receptor blockade

B A Meyer 1,2,✉, J E Dickinson 1, S W Walsh 1, V M Parisi 1
PMCID: PMC2365321  PMID: 18475435

Abstract

We hypothesized that foetal administration of SQ-29,548, a putative thromboxane receptor blocker, would prevent foeto–placental vasoconstriction produced by the thromboxane mimic U46619. Arterial blood gases, continuous monitoring of maternal and foetal heart rates and blood pressures were performed in chronically catheterized pregnant ewes. Foetal blood flows and vascular resistance were determined with radioactive microspheres. SQ-29,548 effectively blocked the expected vasoconstrictive effects of thromboxane. However, prolonged infusion of SQ-29,548 resulted in significant decreases in umbilical–placental blood flow and foetal mean arterial pressure. This was accompanied by a respiratory acidemia. Potential therapy for the vasoconstrictive disorders of pregnancy with SQ-29,548 awaits further investigation of its intrinsic vasoactive properties in the umbilical–placental vasculature.

Full Text

The Full Text of this article is available as a PDF (709.7 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ashton J. H., Schmitz J. M., Campbell W. B., Ogletree M. L., Raheja S., Taylor A. L., Fitzgerald C., Buja L. M., Willerson J. T. Inhibition of cyclic flow variations in stenosed canine coronary arteries by thromboxane A2/prostaglandin H2 receptor antagonists. Circ Res. 1986 Nov;59(5):568–578. doi: 10.1161/01.res.59.5.568. [DOI] [PubMed] [Google Scholar]
  2. Buckberg G. D., Luck J. C., Payne D. B., Hoffman J. I., Archie J. P., Fixler D. E. Some sources of error in measuring regional blood flow with radioactive microspheres. J Appl Physiol. 1971 Oct;31(4):598–604. doi: 10.1152/jappl.1971.31.4.598. [DOI] [PubMed] [Google Scholar]
  3. Nelson D. M., Walsh S. W. Aspirin differentially affects thromboxane and prostacyclin production by trophoblast and villous core compartments of human placental villi. Am J Obstet Gynecol. 1989 Dec;161(6 Pt 1):1593–1598. doi: 10.1016/0002-9378(89)90932-0. [DOI] [PubMed] [Google Scholar]
  4. Ogletree M. L., Harris D. N., Greenberg R., Haslanger M. F., Nakane M. Pharmacological actions of SQ 29,548, a novel selective thromboxane antagonist. J Pharmacol Exp Ther. 1985 Aug;234(2):435–441. [PubMed] [Google Scholar]
  5. Ogletree M. L. Overview of physiological and pathophysiological effects of thromboxane A2. Fed Proc. 1987 Jan;46(1):133–138. [PubMed] [Google Scholar]
  6. Parisi V. M., Walsh S. W. Fetoplacental vascular responses to prostacyclin after thromboxane-induced vasoconstriction. Am J Obstet Gynecol. 1989 Feb;160(2):502–507. doi: 10.1016/0002-9378(89)90481-x. [DOI] [PubMed] [Google Scholar]
  7. Rudolph A. M., Heymann M. A. The circulation of the fetus in utero. Methods for studying distribution of blood flow, cardiac output and organ blood flow. Circ Res. 1967 Aug;21(2):163–184. doi: 10.1161/01.res.21.2.163. [DOI] [PubMed] [Google Scholar]
  8. Schiff E., Peleg E., Goldenberg M., Rosenthal T., Ruppin E., Tamarkin M., Barkai G., Ben-Baruch G., Yahal I., Blankstein J. The use of aspirin to prevent pregnancy-induced hypertension and lower the ratio of thromboxane A2 to prostacyclin in relatively high risk pregnancies. N Engl J Med. 1989 Aug 10;321(6):351–356. doi: 10.1056/NEJM198908103210603. [DOI] [PubMed] [Google Scholar]
  9. Schumacher W. A., Adams H. D., Ogletree M. L. Effect of the thromboxane A2-receptor antagonists, SQ 29,548 and SQ 28,668, on the pulmonary hypertensive response to endotoxemia in swine. Pharmacology. 1987;34(6):301–308. doi: 10.1159/000138284. [DOI] [PubMed] [Google Scholar]
  10. Takagi S., Den K. Prostacyclin and thromboxane A2 in preeclamptic umbilical circulation. Adv Prostaglandin Thromboxane Leukot Res. 1985;15:619–621. [PubMed] [Google Scholar]
  11. Thorp J. A., Walsh S. W., Brath P. C. Low-dose aspirin inhibits thromboxane, but not prostacyclin, production by human placental arteries. Am J Obstet Gynecol. 1988 Dec;159(6):1381–1384. doi: 10.1016/0002-9378(88)90560-1. [DOI] [PubMed] [Google Scholar]
  12. Trudinger B. J., Connelly A. J., Giles W. B., Hales J. R., Wilcox G. R. The effects of prostacyclin and thromboxane analogue (U46619) on the fetal circulation and umbilical flow velocity waveforms. J Dev Physiol. 1989 Mar;11(3):179–184. [PubMed] [Google Scholar]
  13. Wallenburg H. C., Dekker G. A., Makovitz J. W., Rotmans P. Low-dose aspirin prevents pregnancy-induced hypertension and pre-eclampsia in angiotensin-sensitive primigravidae. Lancet. 1986 Jan 4;1(8471):1–3. doi: 10.1016/s0140-6736(86)91891-x. [DOI] [PubMed] [Google Scholar]
  14. Walsh S. W. Preeclampsia: an imbalance in placental prostacyclin and thromboxane production. Am J Obstet Gynecol. 1985 Jun 1;152(3):335–340. doi: 10.1016/s0002-9378(85)80223-4. [DOI] [PubMed] [Google Scholar]
  15. Ylikorkala O., Mäkilä U. M., Viinikka L. Amniotic fluid prostacyclin and thromboxane in normal, preeclamptic, and some other complicated pregnancies. Am J Obstet Gynecol. 1981 Nov 1;141(5):487–490. doi: 10.1016/s0002-9378(15)33265-8. [DOI] [PubMed] [Google Scholar]
  16. Ylikorkala O., Viinikka L. Thromboxane A2 in pregnancy and puerperium. Br Med J. 1980 Dec 13;281(6255):1601–1602. doi: 10.1136/bmj.281.6255.1601. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Mediators of Inflammation are provided here courtesy of Wiley

RESOURCES