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. 1992;1(4):241–246. doi: 10.1155/S096293519200036X

Neuropeptide modulation of lymphatic smooth muscle tone in the canine forelimb

David E Dobbins 1,✉
PMCID: PMC2365347  PMID: 18475467

Abstract

Neurokinin A and B are putative inflammatory mediators. We assessed their ability to alter prenodal lymphatic resistance. Intralymphatic neurokinin A (3.0 × 10−6, 3.0 × 10−5 and 3.0 × 10−4 mol l−1) significantly constricted lymphatics at the two highest doses. Preliminary experiments suggested that neurokinin B might dilate lymphatics. To test this, lymphatic pressure was increased by norepinephrine (3.1 × 10−6 mol l−1). Neurokinin B (2.7 × 10−4 mol l−1) was then infused intralymphatically during norepinephrine infusion. Norepinephrine increased perfusion pressure from 5.6 ± 0.6 mmHg to 12.1 ± 1.4 mmHg. Subsequent infusion of neurokinin B significantly decreased lymphatic perfusion pressure from 11.9 ± 1.3 mmHg to 9.9 ± 1.1 mmHg. These data indicate that neurokinin A and B can alter lymphatic resistance and are consistent with the hypothesis that lymph vessel function may be subject to modulation by neurokinins.

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Selected References

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  1. Dabney J. M., Buehn M. J., Dobbins D. E. Constriction of lymphatics by catecholamines, carotid occlusion, or hemorrhage. Am J Physiol. 1988 Sep;255(3 Pt 2):H514–H524. doi: 10.1152/ajpheart.1988.255.3.H514. [DOI] [PubMed] [Google Scholar]
  2. Dabney J. M., Buehn M. J., Dobbins D. E. Perfused prenodal lymphatics are constricted by prostaglandins. Am J Physiol. 1991 Jan;260(1 Pt 2):H1–H5. doi: 10.1152/ajpheart.1991.260.1.H1. [DOI] [PubMed] [Google Scholar]
  3. Devillier P., Weill B., Renoux M., Menkès C., Pradelles P. Elevated levels of tachykinin-like immunoreactivity in joint fluids from patients with rheumatic inflammatory diseases. N Engl J Med. 1986 May 15;314(20):1323–1323. doi: 10.1056/NEJM198605153142018. [DOI] [PubMed] [Google Scholar]
  4. Dobbins D. E., Buehn M. J., Dabney J. M. Constriction of perfused lymphatics by acetylcholine, bradykinin and histamine. Microcirc Endothelium Lymphatics. 1990 Dec;6(6):409–425. [PubMed] [Google Scholar]
  5. Dobbins D. E., Buehn M. J., Dabney J. M. Neurokinin A and B: potent vasodilators in the canine forelimb. Microcirc Endothelium Lymphatics. 1990 Aug-Oct;6(4-5):253–266. [PubMed] [Google Scholar]
  6. Dobbins D. E., Dabney J. M. Endothelin-mediated constriction of prenodal lymphatic vessels in the canine forelimb. Regul Pept. 1991 Jul 23;35(1):81–91. doi: 10.1016/0167-0115(91)90256-g. [DOI] [PubMed] [Google Scholar]
  7. Fuller R. W., Conradson T. B., Dixon C. M., Crossman D. C., Barnes P. J. Sensory neuropeptide effects in human skin. Br J Pharmacol. 1987 Dec;92(4):781–788. doi: 10.1111/j.1476-5381.1987.tb11381.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Gamse R., Saria A. Potentiation of tachykinin-induced plasma protein extravasation by calcitonin gene-related peptide. Eur J Pharmacol. 1985 Aug 7;114(1):61–66. doi: 10.1016/0014-2999(85)90520-5. [DOI] [PubMed] [Google Scholar]
  9. Ichikawa S., Kasahara D., Iwanaga T., Uchino S., Fujita T. Peptidergic nerve terminals associated with the central lacteal lymphatics in the ileal villi of dogs. Arch Histol Cytol. 1991 Jul;54(3):311–320. doi: 10.1679/aohc.54.311. [DOI] [PubMed] [Google Scholar]
  10. Ichikawa S., Shiozawa M., Iwanaga T., Uchino S. Immunohistochemical demonstration of peptidergic nerve fibers associated with the central lacteal lymphatics in the duodenal villi of dogs. Arch Histol Cytol. 1991 May;54(2):241–248. doi: 10.1679/aohc.54.241. [DOI] [PubMed] [Google Scholar]
  11. Ito Y., Magari S., Sakanaka M. Immunoelectron-microscopic localization of peptidergic nerve fibers around lymphatic capillaries in the rat liver. Arch Histol Cytol. 1990;53 (Suppl):199–208. doi: 10.1679/aohc.53.suppl_199. [DOI] [PubMed] [Google Scholar]
  12. Kangawa K., Minamino N., Fukuda A., Matsuo H. Neuromedin K: a novel mammalian tachykinin identified in porcine spinal cord. Biochem Biophys Res Commun. 1983 Jul 29;114(2):533–540. doi: 10.1016/0006-291x(83)90813-6. [DOI] [PubMed] [Google Scholar]
  13. Lewis D. A., Bloom F. E. Clinical perspectives on neuropeptides. Annu Rev Med. 1987;38:143–148. doi: 10.1146/annurev.me.38.020187.001043. [DOI] [PubMed] [Google Scholar]
  14. Lundin L., Norheim I., Landelius J., Oberg K., Theodorsson-Norheim E. Carcinoid heart disease: relationship of circulating vasoactive substances to ultrasound-detectable cardiac abnormalities. Circulation. 1988 Feb;77(2):264–269. doi: 10.1161/01.cir.77.2.264. [DOI] [PubMed] [Google Scholar]
  15. Maggio J. E. Tachykinins. Annu Rev Neurosci. 1988;11:13–28. doi: 10.1146/annurev.ne.11.030188.000305. [DOI] [PubMed] [Google Scholar]
  16. Sann H., Pinter E., Szolcsányi J., Pierau F. K. Peptidergic afferents might contribute to the regulation of skin blood flow. Agents Actions. 1988 Feb;23(1-2):14–15. doi: 10.1007/BF01967172. [DOI] [PubMed] [Google Scholar]
  17. Struble R. G., Powers R. E., Casanova M. F., Kitt C. A., Brown E. C., Price D. L. Neuropeptidergic systems in plaques of Alzheimer's disease. J Neuropathol Exp Neurol. 1987 Sep;46(5):567–584. doi: 10.1097/00005072-198709000-00006. [DOI] [PubMed] [Google Scholar]
  18. Thompson D. C., Diamond L., Altiere R. J. Enzymatic modulation of vasoactive intestinal peptide and nonadrenergic noncholinergic inhibitory responses in guinea pig tracheae. Am Rev Respir Dis. 1990 Nov;142(5):1119–1123. doi: 10.1164/ajrccm/142.5.1119. [DOI] [PubMed] [Google Scholar]
  19. Uchida Y., Nomura A., Ohtsuka M., Hasegawa S., Goto K., Kimura S., Sugita Y., Uchiyama Y. Neurokinin A as a potent bronchoconstrictor. Am Rev Respir Dis. 1987 Sep;136(3):718–721. doi: 10.1164/ajrccm/136.3.718. [DOI] [PubMed] [Google Scholar]

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