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. 1992;1(6):371–374. doi: 10.1155/S0962935192000553

Study on the pathogenesis of pathophysiological changes of burn systemic infection

Li Ao (Ngao) 1,✉, Huang Yuesheng 1, Yang Zongcheng 1
PMCID: PMC2365372  PMID: 18475486

Abstract

The present prospective study showed that incidence of systemic infection in severe burn patients was 30.9%. Toxic shock and multiple organ failure (MOF) developed in all patients with uncontrolled systemic infection. Both morbidity and mortality of MOF were 76.5%. In the infection group, plasma TXB2 and TXB2/6-keto-PGF1α ratio increased markedly. Their changes were closely correlated with the clinical course and deterioration of systemic infection. Circulatory platelet aggregate ratio decreased significantly, while myocardiac enzyme spectrum greatly increased. Thrombi were observed in visceral tissues from patients dying of systemic infection. These suggested that TXA2/PGI2. imbalance promoting microaggregate and thrombus formation may be one of the pathogenic effects of toxic shock and MOF in burn patients.

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Selected References

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