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. 1993;2(1):27–31. doi: 10.1155/S0962935193000031

Formation of 4-hydroxynonenal and further aldehydic mediators of inflammation during bromotrichlorornethane treatment of rat liver cells

Olaf Sommerburg 1, Tilman Grune 1, Sabine Klee 2, Fritz R Ungemach 2, Werner G Siems 3,✉
PMCID: PMC2365379  PMID: 18475499

Abstract

Bromotrichloromethane (CBrCl3) treatment is a model for studies on molecular mechanisms of haloalkane toxicity with some advantages compared with CCl4 treatment. The formation of 4-hydroxynonenal and similar aldehydic products of lipid peroxidation, which play a role as mediators of inflammatory processes, was clearly demonstrated in rat hepatocytes treated with CBrCl3. It may be assumed that haloalkane toxicity is connected with the biological effects of those inflammation mediatory aldehydic compounds.

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Selected References

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  1. Albrecht D. K., Kappus H., Remmer H. Lipid peroxidation and cell damage in isolated hepatocytes due to bromotrichloromethane. Toxicol Appl Pharmacol. 1978 Nov;46(2):499–505. doi: 10.1016/0041-008x(78)90095-9. [DOI] [PubMed] [Google Scholar]
  2. Arii S., Monden K., Itai S., Sasaoki T., Adachi Y., Funaki N., Higashitsuji H., Tobe T. Depressed function of Kupffer cells in rats with CCl4-induced liver cirrhosis. Res Exp Med (Berl) 1990;190(3):173–182. doi: 10.1007/pl00020020. [DOI] [PubMed] [Google Scholar]
  3. Berry M. N., Friend D. S. High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study. J Cell Biol. 1969 Dec;43(3):506–520. doi: 10.1083/jcb.43.3.506. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Curzio M., Esterbauer H., Dianzani M. U. Chemotactic activity of hydroxyalkenals on rat neutrophils. Int J Tissue React. 1985;7(2):137–142. [PubMed] [Google Scholar]
  5. Curzio M. Interaction between neutrophils and 4-hydroxyalkenals and consequences on neutrophil motility. Free Radic Res Commun. 1988;5(2):55–66. doi: 10.3109/10715768809066912. [DOI] [PubMed] [Google Scholar]
  6. Esterbauer H., Cheeseman K. H. Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal. Methods Enzymol. 1990;186:407–421. doi: 10.1016/0076-6879(90)86134-h. [DOI] [PubMed] [Google Scholar]
  7. Esterbauer H., Schaur R. J., Zollner H. Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. Free Radic Biol Med. 1991;11(1):81–128. doi: 10.1016/0891-5849(91)90192-6. [DOI] [PubMed] [Google Scholar]
  8. Esterbauer H., Zollner H. Methods for determination of aldehydic lipid peroxidation products. Free Radic Biol Med. 1989;7(2):197–203. doi: 10.1016/0891-5849(89)90015-4. [DOI] [PubMed] [Google Scholar]
  9. Grune T., Siems W., Kowalewski J., Zollner H., Esterbauer H. Identification of metabolic pathways of the lipid peroxidation product 4-hydroxynonenal by enterocytes of rat small intestine. Biochem Int. 1991 Dec;25(5):963–971. [PubMed] [Google Scholar]
  10. Janero D. R. Malondialdehyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury. Free Radic Biol Med. 1990;9(6):515–540. doi: 10.1016/0891-5849(90)90131-2. [DOI] [PubMed] [Google Scholar]
  11. Koch R. R., Glende E. A., Jr, Recknagel R. O. Hepatotoxicity of bromotrichloromethane--bond dissociation energy and lipoperoxidation. Biochem Pharmacol. 1974 Oct 15;23(20):2907–2915. doi: 10.1016/0006-2952(74)90065-3. [DOI] [PubMed] [Google Scholar]
  12. McGirr L. G., Khan S., Lauriault V., O'Brien P. J. Molecular mechanisms for bromotrichloromethane cytotoxicity in isolated rat hepatocytes. Xenobiotica. 1990 Sep;20(9):933–943. doi: 10.3109/00498259009046909. [DOI] [PubMed] [Google Scholar]
  13. Recknagel R. O., Ghoshal A. K. Lipoperoxidation as a vector in carbon tetrachloride hepatotoxicity. Lab Invest. 1966 Jan;15(1 Pt 1):132–148. [PubMed] [Google Scholar]
  14. Rossi M. A., Fidale F., Garramone A., Esterbauer H., Dianzani M. U. Effect of 4-hydroxylalkenals on hepatic phosphatidylinositol-4,5-bisphosphate-phospholipase C. Biochem Pharmacol. 1990 Jun 1;39(11):1715–1719. doi: 10.1016/0006-2952(90)90116-3. [DOI] [PubMed] [Google Scholar]
  15. Siems W. G., Grune T., Beierl B., Zollner H., Esterbauer H. The metabolism of 4-hydroxynonenal, a lipid peroxidation product, is dependent on tumor age in Ehrlich mouse ascites cells. EXS. 1992;62:124–135. doi: 10.1007/978-3-0348-7460-1_13. [DOI] [PubMed] [Google Scholar]
  16. Stryer L., Bourne H. R. G proteins: a family of signal transducers. Annu Rev Cell Biol. 1986;2:391–419. doi: 10.1146/annurev.cb.02.110186.002135. [DOI] [PubMed] [Google Scholar]
  17. Tsuchiya M., Okimasu E., Ueda W., Hirakawa M., Utsumi K. Halothane, an inhalation anesthetic, activates protein kinase C and superoxide generation by neutrophils. FEBS Lett. 1988 Dec 19;242(1):101–105. doi: 10.1016/0014-5793(88)80994-3. [DOI] [PubMed] [Google Scholar]
  18. Ungemach F. R. Pathobiochemical mechanisms of hepatocellular damage following lipid peroxidation. Chem Phys Lipids. 1987 Nov-Dec;45(2-4):171–205. doi: 10.1016/0009-3084(87)90065-x. [DOI] [PubMed] [Google Scholar]
  19. Vincent M. F., Van den Berghe G., Hers H. G. The pathway of adenine nucleotide catabolism and its control in isolated rat hepatocytes subjected to anoxia. Biochem J. 1982 Jan 15;202(1):117–123. doi: 10.1042/bj2020117. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Werner A., Siems W., Grune T., Schreiter C. Interrelation between nucleotide degradation and aldehyde formation in red blood cells. Influence of xanthine oxidase on metabolism: an application of nucleotide and aldehyde analyses by high-performance liquid chromatography. J Chromatogr. 1990 May 16;507:311–319. doi: 10.1016/s0021-9673(01)84208-4. [DOI] [PubMed] [Google Scholar]
  21. Wong S. H., Knight J. A., Hopfer S. M., Zaharia O., Leach C. N., Jr, Sunderman F. W., Jr Lipoperoxides in plasma as measured by liquid-chromatographic separation of malondialdehyde-thiobarbituric acid adduct. Clin Chem. 1987 Feb;33(2 Pt 1):214–220. [PubMed] [Google Scholar]

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