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. 1993;2(4):317–322. doi: 10.1155/S0962935193000444

Phosphoinositide hydrolysis mediated by H1 receptors in autoimmune myocarditis mice

Nora Goren 1, Claudia Perez Leiros 1, Leonor Sterin-Borda 1, Enri S Borda 1,✉
PMCID: PMC2365419  PMID: 18475540

Abstract

Stimulation of phosphoinositide hydrolysis in myocardium from autoimmune myocarditis mice by ThEA and histamine was assayed. Myocardium from autoimmune heart, but not the normal forms, specifically increased phosphoinositide turnover in the presence of histaminergic agonists. This increment was blocked by a specific H1 antagonist mepyramine and to the same extent by the phospholipase C inhibitor NCDC. By using a binding assay H1 histaminergic receptors were detected in autoimmune heart membrane preparations, but this was not observed in normal heart. These data suggest that autoimmune myocardium expressed a functional H1 receptor that could involve a distinctive mechanism operating in the disease.

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Selected References

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  1. Berger D., Marzinzig E., Marzinzig M., Beger H. G. Quantitative endotoxin determination in blood--chromogenic modification of the limulus amebocyte lysate test. Eur Surg Res. 1988;20(2):128–136. doi: 10.1159/000128751. [DOI] [PubMed] [Google Scholar]
  2. Függer R., Hamilton G., Steininger R., Mirza D., Schulz F., Mühlbacher F. Intraoperative estimation of endotoxin, TNF alpha, and IL-6 in orthotopic liver transplantation and their relation to rejection and postoperative infection. Transplantation. 1991 Aug;52(2):302–306. doi: 10.1097/00007890-199108000-00022. [DOI] [PubMed] [Google Scholar]
  3. Goto M., Takei Y., Kawano S., Tsuji S., Fukui H., Fushimi H., Nishimura Y., Kashiwagi T., Fusamoto H., Kamada T. Tumor necrosis factor and endotoxin in the pathogenesis of liver and pulmonary injuries after orthotopic liver transplantation in the rat. Hepatology. 1992 Aug;16(2):487–493. doi: 10.1002/hep.1840160230. [DOI] [PubMed] [Google Scholar]
  4. Halloran P. F., Wadgymar A., Autenried P. The regulation of expression of major histocompatibility complex products. Transplantation. 1986 Apr;41(4):413–420. [PubMed] [Google Scholar]
  5. Hamilton G., Prettenhofer M., Zommer A., Hofbauer S., Götzinger P., Gnant F. X., Függer R. Intraoperative course and prognostic significance of endotoxin, tumor necrosis factor-alpha and interleukin-6 in liver transplant recipients. Immunobiology. 1991 Aug;182(5):425–439. doi: 10.1016/s0171-2985(11)80207-x. [DOI] [PubMed] [Google Scholar]
  6. Hamilton G., Tüchy G., Hamilton B. Intraoperative kinetics and regional distribution of interleukin-6 during human liver transplantation. Transplantation. 1992 Oct;54(4):746–748. doi: 10.1097/00007890-199210000-00039. [DOI] [PubMed] [Google Scholar]
  7. Howard T. K., Klintmalm G. B., Cofer J. B., Husberg B. S., Goldstein R. M., Gonwa T. A. The influence of preservation injury on rejection in the hepatic transplant recipient. Transplantation. 1990 Jan;49(1):103–107. doi: 10.1097/00007890-199001000-00023. [DOI] [PubMed] [Google Scholar]
  8. Imagawa D. K., Millis J. M., Olthoff K. M., Derus L. J., Chia D., Sugich L. R., Ozawa M., Dempsey R. A., Iwaki Y., Levy P. J. The role of tumor necrosis factor in allograft rejection. I. Evidence that elevated levels of tumor necrosis factor-alpha predict rejection following orthotopic liver transplantation. Transplantation. 1990 Aug;50(2):219–225. doi: 10.1097/00007890-199008000-00009. [DOI] [PubMed] [Google Scholar]
  9. Kraus T., Noronha I. L., Manner M., Klar E., Küppers P., Otto G. Clinical value of cytokine determination for screening, differentiation, and therapy monitoring of infectious and noninfectious complications after orthotopic liver transplantation. Transplant Proc. 1991 Feb;23(1 Pt 2):1509–1512. [PubMed] [Google Scholar]
  10. Mor E., Solomon H., Gibbs J. F., Holman M. J., Goldstein R. M., Husberg B. S., Gonwa T. A., Klintmalm G. B. Acute cellular rejection following liver transplantation: clinical pathologic features and effect on outcome. Semin Liver Dis. 1992 Feb;12(1):28–40. doi: 10.1055/s-2007-1007374. [DOI] [PubMed] [Google Scholar]
  11. Quiroga J., Colina I., Demetris A. J., Starzl T. E., Van Thiel D. H. Cause and timing of first allograft failure in orthotopic liver transplantation: a study of 177 consecutive patients. Hepatology. 1991 Dec;14(6):1054–1062. [PubMed] [Google Scholar]
  12. Starzl T. E., Demetris A. J., Van Thiel D. Liver transplantation (2). N Engl J Med. 1989 Oct 19;321(16):1092–1099. doi: 10.1056/NEJM198910193211606. [DOI] [PubMed] [Google Scholar]
  13. Yokoyama I., Todo S., Miyata T., Selby R., Tzakis A. G., Starzl T. E. Endotoxemia and human liver transplantation. Transplant Proc. 1989 Oct;21(5):3833–3841. [PMC free article] [PubMed] [Google Scholar]

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