Skip to main content
NCBI home page
Mediators of Inflammation logoLink to Mediators of Inflammation
. 1994;3(5):335–340. doi: 10.1155/S0962935194000463

Changes in Eicosanoid and Tumour Necrosis Factor-α Production by Rat Peritoneal Macrophages During Carrageenin-Induced Peritonitis

W M Pruimboom 1,✉, A Verdoold 1, C J A M Tak 1, A P M van Dijk 1, M van Batenburg 1, J H P Wilson 2, F J Zijlstra 1
PMCID: PMC2365571  PMID: 18475577

Abstract

Changes and correlations in cytokine and eicosanoid production by blood monocytes, non-purified and purified peritoneal cells during a carrageenin-induced peritonitis were investigated for a period of ten days. The cells were isolated and stimulated in vitro. Cytokine and eicosanoid production of the non-purified fraction increased steadily during peritonitis. During the whole episode of peritonitis the production capacity of granulocytes was very low and hardly any effect on the production capacity of macrophages (Mϕ) was observed. Cytokine and eicosanoid production of the non-purified fraction was mainly due to the presence of Mϕ. The production capacity of the peripheral blood monocytes was not similar to that of the peritoneal Mϕ.

Full Text

The Full Text of this article is available as a PDF (517.8 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Balkwill F. R., Burke F. The cytokine network. Immunol Today. 1989 Sep;10(9):299–304. doi: 10.1016/0167-5699(89)90085-6. [DOI] [PubMed] [Google Scholar]
  2. Ben-Efraim S., Tak C., Fieren M. J., Romijn J. C., Beckmann I., Bonta I. L. Activity of human peritoneal macrophages against a human tumor: role of tumor necrosis factor-alpha, PGE2 and nitrite, in vitro studies. Immunol Lett. 1993 Jul;37(1):27–33. doi: 10.1016/0165-2478(93)90128-o. [DOI] [PubMed] [Google Scholar]
  3. Bonta I. L., Ben-Efraim S. Interactions between inflammatory mediators in expression of antitumor cytostatic activity of macrophages. Immunol Lett. 1990 Sep;25(4):295–301. doi: 10.1016/0165-2478(90)90199-z. [DOI] [PubMed] [Google Scholar]
  4. Cicco N. A., Lindemann A., Content J., Vandenbussche P., Lübbert M., Gauss J., Mertelsmann R., Herrmann F. Inducible production of interleukin-6 by human polymorphonuclear neutrophils: role of granulocyte-macrophage colony-stimulating factor and tumor necrosis factor-alpha. Blood. 1990 May 15;75(10):2049–2052. [PubMed] [Google Scholar]
  5. Cochran F. R., Baxter C. S. Carrageenan-induced suppression of T-lymphocyte proliferation in the rat: abrogation of suppressor factor production by the prostaglandin synthesis inhibitors, indomethacin and ETYA. Immunobiology. 1984 May;166(3):275–285. doi: 10.1016/s0171-2985(84)80045-5. [DOI] [PubMed] [Google Scholar]
  6. Dougherty G. J., McBride W. H. Macrophage heterogeneity. J Clin Lab Immunol. 1984 May;14(1):1–11. [PubMed] [Google Scholar]
  7. Ford-Hutchinson A. W. Leukotrienes: their formation and role as inflammatory mediators. Fed Proc. 1985 Jan;44(1 Pt 1):25–29. [PubMed] [Google Scholar]
  8. Garrelds I. M., Zijlstra F. J., Tak C. J., Bonta I. L., Beckmann I., Ben-Efraim S. A comparison between two methods for measuring tumor necrosis factor in biological fluids. Agents Actions. 1993;38(Spec No):C89–C91. doi: 10.1007/BF01991147. [DOI] [PubMed] [Google Scholar]
  9. Groscurth P. Cytotoxic effector cells of the immune system. Anat Embryol (Berl) 1989;180(2):109–119. doi: 10.1007/BF00309762. [DOI] [PubMed] [Google Scholar]
  10. Hurley J. V., Ryan G. B., Friedman A. The mononuclear response to intrapleural injection in the rat. J Pathol Bacteriol. 1966 Apr;91(2):575–587. doi: 10.1002/path.1700910234. [DOI] [PubMed] [Google Scholar]
  11. Issekutz A. C., Issekutz T. B. Quantitation and kinetics of blood monocyte migration to acute inflammatory reactions, and IL-1 alpha, tumor necrosis factor-alpha, and IFN-gamma. J Immunol. 1993 Aug 15;151(4):2105–2115. [PubMed] [Google Scholar]
  12. Lindemann A., Riedel D., Oster W., Meuer S. C., Blohm D., Mertelsmann R. H., Herrmann F. Granulocyte/macrophage colony-stimulating factor induces interleukin 1 production by human polymorphonuclear neutrophils. J Immunol. 1988 Feb 1;140(3):837–839. [PubMed] [Google Scholar]
  13. Mackay C. R., Imhof B. A. Cell adhesion in the immune system. Immunol Today. 1993 Mar;14(3):99–102. doi: 10.1016/0167-5699(93)90205-Y. [DOI] [PubMed] [Google Scholar]
  14. Malech H. L., Gallin J. I. Current concepts: immunology. Neutrophils in human diseases. N Engl J Med. 1987 Sep 10;317(11):687–694. doi: 10.1056/NEJM198709103171107. [DOI] [PubMed] [Google Scholar]
  15. Migliorisi G., Folkes E., Pawlowski N., Cramer E. B. In vitro studies of human monocyte migration across endothelium in response to leukotriene B4 and f-Met-Leu-Phe. Am J Pathol. 1987 Apr;127(1):157–167. [PMC free article] [PubMed] [Google Scholar]
  16. Mándi Y., Endrész V., Krenács L., Régely K., Degré M., Béládi I. Tumor necrosis factor production by human granulocytes. Int Arch Allergy Appl Immunol. 1991;96(2):102–106. doi: 10.1159/000235479. [DOI] [PubMed] [Google Scholar]
  17. Nathan C. F. Secretory products of macrophages. J Clin Invest. 1987 Feb;79(2):319–326. doi: 10.1172/JCI112815. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Ouwendijk R. J., Zijlstra F. J., van den Broek A. M., Brouwer A., Wilson J. H., Vincent J. E. Comparison of the production of eicosanoids by human and rat peritoneal macrophages and rat Kupffer cells. Prostaglandins. 1988 Mar;35(3):437–446. doi: 10.1016/0090-6980(88)90134-7. [DOI] [PubMed] [Google Scholar]
  19. Samuelsson B., Goldyne M., Granström E., Hamberg M., Hammarström S., Malmsten C. Prostaglandins and thromboxanes. Annu Rev Biochem. 1978;47:997–1029. doi: 10.1146/annurev.bi.47.070178.005025. [DOI] [PubMed] [Google Scholar]
  20. Springer T. A. Adhesion receptors of the immune system. Nature. 1990 Aug 2;346(6283):425–434. doi: 10.1038/346425a0. [DOI] [PubMed] [Google Scholar]
  21. Stein M., Keshav S. The versatility of macrophages. Clin Exp Allergy. 1992 Jan;22(1):19–27. doi: 10.1111/j.1365-2222.1992.tb00110.x. [DOI] [PubMed] [Google Scholar]
  22. Unanue E. R., Allen P. M. The basis for the immunoregulatory role of macrophages and other accessory cells. Science. 1987 May 1;236(4801):551–557. doi: 10.1126/science.2437650. [DOI] [PubMed] [Google Scholar]
  23. Yoss E. B., Spannhake E. W., Flynn J. T., Fish J. E., Peters S. P. Arachidonic acid metabolism in normal human alveolar macrophages: stimulus specificity for mediator release and phospholipid metabolism, and pharmacologic modulation in vitro and in vivo. Am J Respir Cell Mol Biol. 1990 Jan;2(1):69–80. doi: 10.1165/ajrcmb/2.1.69. [DOI] [PubMed] [Google Scholar]
  24. van Furth R., Cohn Z. A. The origin and kinetics of mononuclear phagocytes. J Exp Med. 1968 Sep 1;128(3):415–435. doi: 10.1084/jem.128.3.415. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Mediators of Inflammation are provided here courtesy of Wiley

RESOURCES