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. 1994;3(6):459–463. doi: 10.1155/S0962935194000657

Inhibition of Immune Complex-Induced Inflammation by A small Molecular Weight Selectin Antagonist

X Nair 2, G Todderud 2, L Davern 2, D Lee 2, A Aruffo 1,2, K M Tramposch 2,✉
PMCID: PMC2365589  PMID: 18475596

Abstract

The anti-inflammatory effect of a small molecular weight antagonist of P- and E-selectin-dependent cell adhesion was examined. The glycolipid sulphatide was shown to block the adherence of thrombin-activated rat platelets to HL-60 cells. This interaction is known to be dependent on P-selectin. The rat dermal reverse passive Arthus reaction was used to assess the effect of sulphatide on a neutrophil dependent inflammatory response. Sulphatide dosedependently blocked both the vascular permeability increase and cell infiltration after intraperitoneal administration. These results show that a small molecular weight compound which blocks P- and E-selectin dependent adhesion in vitro can effectively block the inflammation due to immune complex deposition. A compound with this type of profile may have therapeutic potential in the treatment of immune complex mediated diseases.

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Selected References

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