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. 1994;3(7):S43–S47. doi: 10.1155/S096293519400075X

Effect of Nedocromil Sodium on Aspecific Bronchial Hyper-Reactivity in Asthmatic Children

A Fiocchi 1,✉, P Signoroni 1, P Bruni 1, M Galeone 1, E DeCet 1, S Bogacki 1
PMCID: PMC2365600  PMID: 18475604

Abstract

The purpose of this study was to evaluate whether nedocromil sodium benefits urban asthmatic children showing seasonal bronchial hyper-reactivity to ultrasonic nebulization of distilled water (UNDW). A prospective, randomized, placebo-controlled, parallel-group, double-blind study was carried out at the outpatient pulmonology service at a tertiary-care teaching hospital. Twelve children living in Milan, who were 7–17 years of age, who were SPT and RAST-negative to perennial allergens, who were suffering from episodic asthma, and showing seasonal bronchial hyper-reactivity to UNDW during winter, participated in this study. All the children received either placebo or nedocromil sodium, 4 mg every 6 h for 6 weeks. Spirometry and UNDW challenge were done at the following times: day−7; day 0; day 1; day 7; day 14; day 28; day 42. No differences were found in the basal spirometric parameters, which were normal in both nedocromil and placebo groups. Bronchial reactivity to UNDW was found to be significantly decreased in the group treated with nedocromtl starting from day 7. It is therefore concluded that nedocromil sodium can reverse bronchial hyper-reactivity caused by seasonal factors such as cold, viral infections and atmospheric pollutants in children suffering from asthma.

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Selected References

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  1. Allegra L., Bianco S. Non-specific broncho-reactivity obtained with an ultrasonic aerosol of distilled water. Eur J Respir Dis Suppl. 1980;106:41–49. [PubMed] [Google Scholar]
  2. Barnes P. J. New concepts in the pathogenesis of bronchial hyperresponsiveness and asthma. J Allergy Clin Immunol. 1989 Jun;83(6):1013–1026. doi: 10.1016/0091-6749(89)90441-7. [DOI] [PubMed] [Google Scholar]
  3. Boner A. L., Piacentini G. L., Bonizzato C., Dattoli V., Sette L. Effect of inhaled beclomethasone dipropionate on bronchial hyperreactivity in asthmatic children during maximal allergen exposure. Pediatr Pulmonol. 1991;10(1):2–5. doi: 10.1002/ppul.1950100102. [DOI] [PubMed] [Google Scholar]
  4. Boushey H. A., Holtzman M. J., Sheller J. R., Nadel J. A. Bronchial hyperreactivity. Am Rev Respir Dis. 1980 Feb;121(2):389–413. doi: 10.1164/arrd.1980.121.2.389. [DOI] [PubMed] [Google Scholar]
  5. Britton J. R., Burney P. G., Chinn S., Papacosta A. O., Tattersfield A. E. The relation between change in airway reactivity and change in respiratory symptoms and medication in a community study. Am Rev Respir Dis. 1988 Sep;138(3):530–534. doi: 10.1164/ajrccm/138.3.530. [DOI] [PubMed] [Google Scholar]
  6. Crimi E., Brusasco V., Brancatisano M., Losurdo E., Crimi P. Effect of nedocromil sodium on adenosine- and methacholine-induced bronchospasm in asthma. Clin Allergy. 1987 Mar;17(2):135–141. doi: 10.1111/j.1365-2222.1987.tb02331.x. [DOI] [PubMed] [Google Scholar]
  7. Dahl R., Haahtela T. Prophylactic pharmacologic treatment of asthma. Allergy. 1992 Dec;47(6):588–593. doi: 10.1111/j.1398-9995.1992.tb02379.x. [DOI] [PubMed] [Google Scholar]
  8. Dorward A. J., Roberts J. A., Thomson N. C. Effect of nedocromil sodium on histamine airway responsiveness in grass-pollen sensitive asthmatics during the pollen season. Clin Allergy. 1986 Jul;16(4):309–315. doi: 10.1111/j.1365-2222.1986.tb01962.x. [DOI] [PubMed] [Google Scholar]
  9. Hargreave F. E., Ramsdale E. H., Kirby J. G., O'Byrne P. M. Asthma and the role of inflammation. Eur J Respir Dis Suppl. 1986;147:16–21. [PubMed] [Google Scholar]
  10. Henry R. L., Abramson R., Adler J. A., Wlodarcyzk J., Hensley M. J. Asthma in the vicinity of power stations: I. A prevalence study. Pediatr Pulmonol. 1991;11(2):127–133. doi: 10.1002/ppul.1950110209. [DOI] [PubMed] [Google Scholar]
  11. Jackson D. M., Eady R. P. Acute transient SO2-induced airway hyperreactivity: effects of nedocromil sodium. J Appl Physiol (1985) 1988 Sep;65(3):1119–1124. doi: 10.1152/jappl.1988.65.3.1119. [DOI] [PubMed] [Google Scholar]
  12. Juniper E. F., Frith P. A., Hargreave F. E. Airway responsiveness to histamine and methacholine: relationship to minimum treatment to control symptoms of asthma. Thorax. 1981 Aug;36(8):575–579. doi: 10.1136/thx.36.8.575. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Richards W. Effects of air pollution on asthma. Ann Allergy. 1990 Nov;65(5):345–347. [PubMed] [Google Scholar]
  14. Robuschi M., Vaghi A., Simone P., Bianco S. Prevention of fog-induced bronchospasm by nedocromil sodium. Clin Allergy. 1987 Jan;17(1):69–74. doi: 10.1111/j.1365-2222.1987.tb02321.x. [DOI] [PubMed] [Google Scholar]
  15. Sedgwick J. B., Bjornsdottir U., Geiger K. M., Busse W. W. Inhibition of eosinophil density change and leukotriene C4 generation by nedocromil sodium. J Allergy Clin Immunol. 1992 Aug;90(2):202–209. doi: 10.1016/0091-6749(92)90072-a. [DOI] [PubMed] [Google Scholar]
  16. Slapke J., Vucelic B., Schütt C., Müller S. Der Einfluss klimatischer und meteorologischer Faktoren auf die bronchiale Hyperreaktivität und den Verlauf von Asthma-bronchiale-Erkrankungen und ihre potentielle Bedeutung in der Asthmaprophylaxe: Hypothesen, methodische Ansätze und erste Erkenntnisse. Z Erkr Atmungsorgane. 1989;173(2):116–126. [PubMed] [Google Scholar]
  17. Spinaci S., Arossa W., Bugiani M., Natale P., Bucca C., de Candussio G. The effects of air pollution on the respiratory health of children: a cross-sectional study. Pediatr Pulmonol. 1985 Sep-Oct;1(5):262–266. doi: 10.1002/ppul.1950010508. [DOI] [PubMed] [Google Scholar]
  18. Townley R. G., Ryo U. Y., Kolotkin B. M., Kang B. Bronchial sensitivity to methacholine in current and former asthmatic and allergic rhinitis patients and control subjects. J Allergy Clin Immunol. 1975 Dec;56(6):429–442. doi: 10.1016/0091-6749(75)90061-5. [DOI] [PubMed] [Google Scholar]
  19. Vittori E., Sciacca F., Colotta F., Mantovani A., Mattoli S. Protective effect of nedocromil sodium on the interleukin-1-induced production of interleukin-8 in human bronchial epithelial cells. J Allergy Clin Immunol. 1992 Jul;90(1):76–84. doi: 10.1016/s0091-6749(06)80013-8. [DOI] [PubMed] [Google Scholar]

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