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. 1995 May;4(3):163–174. doi: 10.1155/S0962935195000275

Sexual dimorphism of stress response and immune/ inflammatory reaction: the corticotropin releasing hormone perspective

Nicholas V Vamvakopoulos 1
PMCID: PMC2365637  PMID: 18475634

Abstract

This review higlghts key aspects of corticotropin releasing hormone (CRH) biology of potential relevance to the sexual dimorphism of the stress response and immune/inflammatory reaction, and introduces two important new concepts based on the regulatory potential of the human (h) CRH gene: (1) a proposed mechanism to account for the tissue-specific antithetical responses of hCRH gene expression to glucocorticolds, that may also explain the frequently observed antithetical effects of chronic glucocorticoid administration in clinical practice and (2) a heuristic diagram to illustrate the proposed modulation of the stress response and immune/ inflammatory reaction by steroid hormones, from the perspective of the CRH system.

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Selected References

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  1. Abou-Samra A. B., Harwood J. P., Catt K. J., Aguilera G. Mechanisms of action of CRF and other regulators of ACTH release in pituitary corticotrophs. Ann N Y Acad Sci. 1987;512:67–84. doi: 10.1111/j.1749-6632.1987.tb24951.x. [DOI] [PubMed] [Google Scholar]
  2. Adler G. K., Rosen L. B., Fiandaca M. J., Majzoub J. A. Protein kinase-C activation increases the quantity and poly(A) tail length of corticotropin-releasing hormone messenger RNA in NPLC cells. Mol Endocrinol. 1992 Mar;6(3):476–484. doi: 10.1210/mend.6.3.1350054. [DOI] [PubMed] [Google Scholar]
  3. Adler G. K., Smas C. M., Majzoub J. A. Expression and dexamethasone regulation of the human corticotropin-releasing hormone gene in a mouse anterior pituitary cell line. J Biol Chem. 1988 Apr 25;263(12):5846–5852. [PubMed] [Google Scholar]
  4. Allen J. B., Blatter D., Calandra G. B., Wilder R. L. Sex hormonal effects on the severity of streptococcal cell wall-induced polyarthritis in the rat. Arthritis Rheum. 1983 Apr;26(4):560–563. doi: 10.1002/art.1780260418. [DOI] [PubMed] [Google Scholar]
  5. Angel P., Imagawa M., Chiu R., Stein B., Imbra R. J., Rahmsdorf H. J., Jonat C., Herrlich P., Karin M. Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor. Cell. 1987 Jun 19;49(6):729–739. doi: 10.1016/0092-8674(87)90611-8. [DOI] [PubMed] [Google Scholar]
  6. Angioni S., Petraglia F., Gallinelli A., Cossarizza A., Franceschi C., Muscettola M., Genazzani A. D., Surico N., Genazzani A. R. Corticotropin-releasing hormone modulates cytokines release in cultured human peripheral blood mononuclear cells. Life Sci. 1993;53(23):1735–1742. doi: 10.1016/0024-3205(93)90160-5. [DOI] [PubMed] [Google Scholar]
  7. Antoni F. A. Hypothalamic control of adrenocorticotropin secretion: advances since the discovery of 41-residue corticotropin-releasing factor. Endocr Rev. 1986 Nov;7(4):351–378. doi: 10.1210/edrv-7-4-351. [DOI] [PubMed] [Google Scholar]
  8. Arbiser J. L., Morton C. C., Bruns G. A., Majzoub J. A. Human corticotropin releasing hormone gene is located on the long arm of chromosome 8. Cytogenet Cell Genet. 1988;47(3):113–116. doi: 10.1159/000132525. [DOI] [PubMed] [Google Scholar]
  9. Axelrod J., Reisine T. D. Stress hormones: their interaction and regulation. Science. 1984 May 4;224(4648):452–459. doi: 10.1126/science.6143403. [DOI] [PubMed] [Google Scholar]
  10. Ballard P. L., Baxter J. D., Higgins S. J., Rousseau G. G., Tomkins G. M. General presence of glucocorticoid receptors in mammalian tissues. Endocrinology. 1974 Apr;94(4):998–1002. doi: 10.1210/endo-94-4-998. [DOI] [PubMed] [Google Scholar]
  11. Baxter J. D., Forsham P. H. Tissue effects of glucocorticoids. Am J Med. 1972 Nov;53(5):573–589. doi: 10.1016/0002-9343(72)90154-4. [DOI] [PubMed] [Google Scholar]
  12. Beato M. Gene regulation by steroid hormones. Cell. 1989 Feb 10;56(3):335–344. doi: 10.1016/0092-8674(89)90237-7. [DOI] [PubMed] [Google Scholar]
  13. Bernardini R., Calogero A. E., Ehrlich Y. H., Brucke T., Chrousos G. P., Gold P. W. The alkyl-ether phospholipid platelet-activating factor is a stimulator of the hypothalamic-pituitary-adrenal axis in the rat. Endocrinology. 1989 Aug;125(2):1067–1073. doi: 10.1210/endo-125-2-1067. [DOI] [PubMed] [Google Scholar]
  14. Bernardini R., Calogero A. E., Mauceri G., Chrousos G. P. Rat hypothalamic corticotropin-releasing hormone secretion in vitro is stimulated by interleukin-1 in an eicosanoid-dependent manner. Life Sci. 1990;47(17):1601–1607. doi: 10.1016/0024-3205(90)90190-3. [DOI] [PubMed] [Google Scholar]
  15. Blackburn M. B., Kingan T. G., Bodnar W., Shabanowitz J., Hunt D. F., Kempe T., Wagner R. M., Raina A. K., Schnee M. E., Ma M. C. Isolation and identification of a new diuretic peptide from the tobacco hornworm, Manduca sexta. Biochem Biophys Res Commun. 1991 Dec 31;181(3):927–932. doi: 10.1016/0006-291x(91)92025-f. [DOI] [PubMed] [Google Scholar]
  16. Bohler H. C., Jr, Zoeller R. T., King J. C., Rubin B. S., Weber R., Merriam G. R. Corticotropin releasing hormone mRNA is elevated on the afternoon of proestrus in the parvocellular paraventricular nuclei of the female rat. Brain Res Mol Brain Res. 1990 Aug;8(3):259–262. doi: 10.1016/0169-328x(90)90025-9. [DOI] [PubMed] [Google Scholar]
  17. Boutillier A. L., Sassone-Corsi P., Loeffler J. P. The protooncogene c-fos is induced by corticotropin-releasing factor and stimulates proopiomelanocortin gene transcription in pituitary cells. Mol Endocrinol. 1991 Sep;5(9):1301–1310. doi: 10.1210/mend-5-9-1301. [DOI] [PubMed] [Google Scholar]
  18. Cadepond F., Binart N., Chambraud B., Jibard N., Schweizer-Groyer G., Segard-Maurel I., Baulieu E. E. Interaction of glucocorticosteroid receptor and wild-type or mutated 90-kDa heat shock protein coexpressed in baculovirus-infected Sf9 cells. Proc Natl Acad Sci U S A. 1993 Nov 15;90(22):10434–10438. doi: 10.1073/pnas.90.22.10434. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Calogero A. E., Bagdy G., Szemeredi K., Tartaglia M. E., Gold P. W., Chrousos G. P. Mechanisms of serotonin receptor agonist-induced activation of the hypothalamic-pituitary-adrenal axis in the rat. Endocrinology. 1990 Apr;126(4):1888–1894. doi: 10.1210/endo-126-4-1888. [DOI] [PubMed] [Google Scholar]
  20. Calogero A. E., Bernardini R., Margioris A. N., Bagdy G., Gallucci W. T., Munson P. J., Tamarkin L., Tomai T. P., Brady L., Gold P. W. Effects of serotonergic agonists and antagonists on corticotropin-releasing hormone secretion by explanted rat hypothalami. Peptides. 1989 Jan-Feb;10(1):189–200. doi: 10.1016/0196-9781(89)90096-x. [DOI] [PubMed] [Google Scholar]
  21. Chan G. C., Hess P., Meenakshi T., Carlstedt-Duke J., Gustafsson J. A., Payvar F. Delayed secondary glucocorticoid response elements. Unusual nucleotide motifs specify glucocorticoid receptor binding to transcribed regions of alpha 2u-globulin DNA. J Biol Chem. 1991 Nov 25;266(33):22634–22644. [PubMed] [Google Scholar]
  22. Chen R., Lewis K. A., Perrin M. H., Vale W. W. Expression cloning of a human corticotropin-releasing-factor receptor. Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):8967–8971. doi: 10.1073/pnas.90.19.8967. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Chikanza I. C., Petrou P., Kingsley G., Chrousos G., Panayi G. S. Defective hypothalamic response to immune and inflammatory stimuli in patients with rheumatoid arthritis. Arthritis Rheum. 1992 Nov;35(11):1281–1288. doi: 10.1002/art.1780351107. [DOI] [PubMed] [Google Scholar]
  24. Chrousos G. P., Gold P. W. The concepts of stress and stress system disorders. Overview of physical and behavioral homeostasis. JAMA. 1992 Mar 4;267(9):1244–1252. [PubMed] [Google Scholar]
  25. Chrousos G. P., Schuermeyer T. H., Doppman J., Oldfield E. H., Schulte H. M., Gold P. W., Loriaux D. L. NIH conference. Clinical applications of corticotropin-releasing factor. Ann Intern Med. 1985 Mar;102(3):344–358. doi: 10.7326/0003-4819-102-3-344. [DOI] [PubMed] [Google Scholar]
  26. Chrousos G. P., Schulte H. M., Oldfield E. H., Gold P. W., Cutler G. B., Jr, Loriaux D. L. The corticotropin-releasing factor stimulation test. An aid in the evaluation of patients with Cushing's syndrome. N Engl J Med. 1984 Mar 8;310(10):622–626. doi: 10.1056/NEJM198403083101004. [DOI] [PubMed] [Google Scholar]
  27. Crofford L. J., Sano H., Karalis K., Webster E. L., Goldmuntz E. A., Chrousos G. P., Wilder R. L. Local secretion of corticotropin-releasing hormone in the joints of Lewis rats with inflammatory arthritis. J Clin Invest. 1992 Dec;90(6):2555–2564. doi: 10.1172/JCI116150. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Dalman F. C., Scherrer L. C., Taylor L. P., Akil H., Pratt W. B. Localization of the 90-kDa heat shock protein-binding site within the hormone-binding domain of the glucocorticoid receptor by peptide competition. J Biol Chem. 1991 Feb 25;266(6):3482–3490. [PubMed] [Google Scholar]
  29. De Souza E. B., Insel T. R., Perrin M. H., Rivier J., Vale W. W., Kuhar M. J. Corticotropin-releasing factor receptors are widely distributed within the rat central nervous system: an autoradiographic study. J Neurosci. 1985 Dec;5(12):3189–3203. doi: 10.1523/JNEUROSCI.05-12-03189.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. Deutsch P. J., Hoeffler J. P., Jameson J. L., Lin J. C., Habener J. F. Structural determinants for transcriptional activation by cAMP-responsive DNA elements. J Biol Chem. 1988 Dec 5;263(34):18466–18472. [PubMed] [Google Scholar]
  31. Diamond M. I., Miner J. N., Yoshinaga S. K., Yamamoto K. R. Transcription factor interactions: selectors of positive or negative regulation from a single DNA element. Science. 1990 Sep 14;249(4974):1266–1272. doi: 10.1126/science.2119054. [DOI] [PubMed] [Google Scholar]
  32. Dunn A. J., Berridge C. W. Physiological and behavioral responses to corticotropin-releasing factor administration: is CRF a mediator of anxiety or stress responses? Brain Res Brain Res Rev. 1990 May-Aug;15(2):71–100. doi: 10.1016/0165-0173(90)90012-d. [DOI] [PubMed] [Google Scholar]
  33. Feek C. M., Marante D. J., Edwards C. R. The hypothalamic-pituitary-adrenal axis. Clin Endocrinol Metab. 1983 Nov;12(3):597–618. doi: 10.1016/s0300-595x(83)80057-7. [DOI] [PubMed] [Google Scholar]
  34. Ferin M., Van Vugt D., Wardlaw S. The hypothalamic control of the menstrual cycle and the role of endogenous opioid peptides. Recent Prog Horm Res. 1984;40:441–485. doi: 10.1016/b978-0-12-571140-1.50015-3. [DOI] [PubMed] [Google Scholar]
  35. Frederiksen S. O., Ekman R., Gottfries C. G., Widerlöv E., Jonsson S. Reduced concentrations of galanin, arginine vasopressin, neuropeptide Y and peptide YY in the temporal cortex but not in the hypothalamus of brains from schizophrenics. Acta Psychiatr Scand. 1991 Apr;83(4):273–277. doi: 10.1111/j.1600-0447.1991.tb05539.x. [DOI] [PubMed] [Google Scholar]
  36. Frim D. M., Robinson B. G., Pasieka K. B., Majzoub J. A. Differential regulation of corticotropin-releasing hormone mRNA in rat brain. Am J Physiol. 1990 Apr;258(4 Pt 1):E686–E692. doi: 10.1152/ajpendo.1990.258.4.E686. [DOI] [PubMed] [Google Scholar]
  37. GUILLEMIN R., ROSENBERG B. Humoral hypothalamic control of anterior pituitary: a study with combined tissue cultures. Endocrinology. 1955 Nov;57(5):599–607. doi: 10.1210/endo-57-5-599. [DOI] [PubMed] [Google Scholar]
  38. Gallucci W. T., Baum A., Laue L., Rabin D. S., Chrousos G. P., Gold P. W., Kling M. A. Sex differences in sensitivity of the hypothalamic-pituitary-adrenal axis. Health Psychol. 1993 Sep;12(5):420–425. doi: 10.1037//0278-6133.12.5.420. [DOI] [PubMed] [Google Scholar]
  39. Gaub M. P., Bellard M., Scheuer I., Chambon P., Sassone-Corsi P. Activation of the ovalbumin gene by the estrogen receptor involves the fos-jun complex. Cell. 1990 Dec 21;63(6):1267–1276. doi: 10.1016/0092-8674(90)90422-b. [DOI] [PubMed] [Google Scholar]
  40. Genedani S., Bernardi M., Baldini M. G., Bertolini A. Influence of CRF and alpha-MSH on the migration of human monocytes in vitro. Neuropeptides. 1992 Oct;23(2):99–102. doi: 10.1016/0143-4179(92)90085-b. [DOI] [PubMed] [Google Scholar]
  41. Grino M., Chrousos G. P., Margioris A. N. The corticotropin releasing hormone gene is expressed in human placenta. Biochem Biophys Res Commun. 1987 Nov 13;148(3):1208–1214. doi: 10.1016/s0006-291x(87)80261-9. [DOI] [PubMed] [Google Scholar]
  42. Grino M., Guillaume V., Boudouresque F., Margioris A. N., Grisoli F., Jaquet P., Oliver C., Conte-Devolx B. Characterization of corticotropin-releasing hormone receptors on human pituitary corticotroph adenomas and their correlation with endogenous glucocorticoids. J Clin Endocrinol Metab. 1988 Aug;67(2):279–283. doi: 10.1210/jcem-67-2-279. [DOI] [PubMed] [Google Scholar]
  43. Guyer R. L. This Week in SCIENCE. Science. 1991 May 31;252(5010):1227–1227. doi: 10.1126/science.252.5010.1227. [DOI] [PubMed] [Google Scholar]
  44. Haas D. A., George S. R. Gonadal regulation of corticotropin-releasing factor immunoreactivity in hypothalamus. Brain Res Bull. 1988 Mar;20(3):361–367. doi: 10.1016/0361-9230(88)90065-2. [DOI] [PubMed] [Google Scholar]
  45. Hai T., Curran T. Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity. Proc Natl Acad Sci U S A. 1991 May 1;88(9):3720–3724. doi: 10.1073/pnas.88.9.3720. [DOI] [PMC free article] [PubMed] [Google Scholar]
  46. Hattori K., Angel P., Le Beau M. M., Karin M. Structure and chromosomal localization of the functional intronless human JUN protooncogene. Proc Natl Acad Sci U S A. 1988 Dec;85(23):9148–9152. doi: 10.1073/pnas.85.23.9148. [DOI] [PMC free article] [PubMed] [Google Scholar]
  47. Hutchison K. A., Scherrer L. C., Czar M. J., Stancato L. F., Chow Y. H., Jove R., Pratt W. B. Regulation of glucocorticoid receptor function through assembly of a receptor-heat shock protein complex. Ann N Y Acad Sci. 1993 Jun 11;684:35–48. doi: 10.1111/j.1749-6632.1993.tb32269.x. [DOI] [PubMed] [Google Scholar]
  48. Inman R. D. Immunologic sex differences and the female predominance in systemic lupus erythematosus. Arthritis Rheum. 1978 Sep-Oct;21(7):849–852. doi: 10.1002/art.1780210718. [DOI] [PubMed] [Google Scholar]
  49. Kalinyak J. E., Dorin R. I., Hoffman A. R., Perlman A. J. Tissue-specific regulation of glucocorticoid receptor mRNA by dexamethasone. J Biol Chem. 1987 Aug 5;262(22):10441–10444. [PubMed] [Google Scholar]
  50. Kalinyak J. E., Griffin C. A., Hamilton R. W., Bradshaw J. G., Perlman A. J., Hoffman A. R. Developmental and hormonal regulation of glucocorticoid receptor messenger RNA in the rat. J Clin Invest. 1989 Dec;84(6):1843–1848. doi: 10.1172/JCI114370. [DOI] [PMC free article] [PubMed] [Google Scholar]
  51. Karalis K., Sano H., Redwine J., Listwak S., Wilder R. L., Chrousos G. P. Autocrine or paracrine inflammatory actions of corticotropin-releasing hormone in vivo. Science. 1991 Oct 18;254(5030):421–423. doi: 10.1126/science.1925600. [DOI] [PubMed] [Google Scholar]
  52. Karin M. Too many transcription factors: positive and negative interactions. New Biol. 1990 Feb;2(2):126–131. [PubMed] [Google Scholar]
  53. Kataoka H., Troetschler R. G., Li J. P., Kramer S. J., Carney R. L., Schooley D. A. Isolation and identification of a diuretic hormone from the tobacco hornworm, Manduca sexta. Proc Natl Acad Sci U S A. 1989 Apr;86(8):2976–2980. doi: 10.1073/pnas.86.8.2976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  54. Kato S., Tora L., Yamauchi J., Masushige S., Bellard M., Chambon P. A far upstream estrogen response element of the ovalbumin gene contains several half-palindromic 5'-TGACC-3' motifs acting synergistically. Cell. 1992 Feb 21;68(4):731–742. doi: 10.1016/0092-8674(92)90148-6. [DOI] [PubMed] [Google Scholar]
  55. Koshida H., Kotake Y. Corticotropin-releasing hormone enhances the superoxide anion production of rabbit peritoneal macrophages stimulated with N-formyl-methionyl-leucyl-phenylalanine. Life Sci. 1994;54(8):539–543. doi: 10.1016/0024-3205(94)90004-3. [DOI] [PubMed] [Google Scholar]
  56. Landschulz W. H., Johnson P. F., Adashi E. Y., Graves B. J., McKnight S. L. Isolation of a recombinant copy of the gene encoding C/EBP. Genes Dev. 1988 Jul;2(7):786–800. doi: 10.1101/gad.2.7.786. [DOI] [PubMed] [Google Scholar]
  57. Lederis K., Letter A., McMaster D., Moore G., Schlesinger D. Complete amino acid sequence of urotensin I, a hypotensive and corticotropin-releasing neuropeptide from Catostomus. Science. 1982 Oct 8;218(4568):162–165. doi: 10.1126/science.6981844. [DOI] [PubMed] [Google Scholar]
  58. Lee C. Q., Yun Y. D., Hoeffler J. P., Habener J. F. Cyclic-AMP-responsive transcriptional activation of CREB-327 involves interdependent phosphorylated subdomains. EMBO J. 1990 Dec;9(13):4455–4465. doi: 10.1002/j.1460-2075.1990.tb07896.x. [DOI] [PMC free article] [PubMed] [Google Scholar] [Retracted]
  59. Lenz H. J., Fisher L. A., Vale W. W., Brown M. R. Corticotropin-releasing factor, sauvagine, and urotensin I: effects on blood flow. Am J Physiol. 1985 Jul;249(1 Pt 2):R85–R90. doi: 10.1152/ajpregu.1985.249.1.R85. [DOI] [PubMed] [Google Scholar]
  60. Luger A., Calogero A. E., Kalogeras K., Gallucci W. T., Gold P. W., Loriaux D. L., Chrousos G. P. Interaction of epidermal growth factor with the hypothalamic-pituitary-adrenal axis: potential physiologic relevance. J Clin Endocrinol Metab. 1988 Feb;66(2):334–337. doi: 10.1210/jcem-66-2-334. [DOI] [PubMed] [Google Scholar]
  61. Mack D. H., Vartikar J., Pipas J. M., Laimins L. A. Specific repression of TATA-mediated but not initiator-mediated transcription by wild-type p53. Nature. 1993 May 20;363(6426):281–283. doi: 10.1038/363281a0. [DOI] [PubMed] [Google Scholar]
  62. Mastorakos G., Chrousos G. P., Weber J. S. Recombinant interleukin-6 activates the hypothalamic-pituitary-adrenal axis in humans. J Clin Endocrinol Metab. 1993 Dec;77(6):1690–1694. doi: 10.1210/jcem.77.6.8263159. [DOI] [PubMed] [Google Scholar]
  63. Mitchell P. J., Tjian R. Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins. Science. 1989 Jul 28;245(4916):371–378. doi: 10.1126/science.2667136. [DOI] [PubMed] [Google Scholar]
  64. Munck A., Guyre P. M., Holbrook N. J. Physiological functions of glucocorticoids in stress and their relation to pharmacological actions. Endocr Rev. 1984 Winter;5(1):25–44. doi: 10.1210/edrv-5-1-25. [DOI] [PubMed] [Google Scholar]
  65. Müller O. A., Stalla G. K., von Werder K. Corticotropin releasing factor: a new tool for the differential diagnosis of Cushing's syndrome. J Clin Endocrinol Metab. 1983 Jul;57(1):227–229. doi: 10.1210/jcem-57-1-227. [DOI] [PubMed] [Google Scholar]
  66. Orth D. N. Corticotropin-releasing hormone in humans. Endocr Rev. 1992 May;13(2):164–191. doi: 10.1210/edrv-13-2-164. [DOI] [PubMed] [Google Scholar]
  67. Owens M. J., Nemeroff C. B. Physiology and pharmacology of corticotropin-releasing factor. Pharmacol Rev. 1991 Dec;43(4):425–473. [PubMed] [Google Scholar]
  68. Parkes D., Rivest S., Lee S., Rivier C., Vale W. Corticotropin-releasing factor activates c-fos, NGFI-B, and corticotropin-releasing factor gene expression within the paraventricular nucleus of the rat hypothalamus. Mol Endocrinol. 1993 Oct;7(10):1357–1367. doi: 10.1210/mend.7.10.8264665. [DOI] [PubMed] [Google Scholar]
  69. Pelletier G., Liao N., Follea N., Govindan M. V. Mapping of estrogen receptor-producing cells in the rat brain by in situ hybridization. Neurosci Lett. 1988 Nov 22;94(1-2):23–28. doi: 10.1016/0304-3940(88)90264-9. [DOI] [PubMed] [Google Scholar]
  70. Perlstein R. S., Mougey E. H., Jackson W. E., Neta R. Interleukin-1 and interleukin-6 act synergistically to stimulate the release of adrenocorticotropic hormone in vivo. Lymphokine Cytokine Res. 1991 Apr;10(1-2):141–146. [PubMed] [Google Scholar]
  71. Petraglia F., Sawchenko P. E., Rivier J., Vale W. Evidence for local stimulation of ACTH secretion by corticotropin-releasing factor in human placenta. Nature. 1987 Aug 20;328(6132):717–719. doi: 10.1038/328717a0. [DOI] [PubMed] [Google Scholar]
  72. Picard D., Khursheed B., Garabedian M. J., Fortin M. G., Lindquist S., Yamamoto K. R. Reduced levels of hsp90 compromise steroid receptor action in vivo. Nature. 1990 Nov 8;348(6297):166–168. doi: 10.1038/348166a0. [DOI] [PubMed] [Google Scholar]
  73. Poli V., Balena R., Fattori E., Markatos A., Yamamoto M., Tanaka H., Ciliberto G., Rodan G. A., Costantini F. Interleukin-6 deficient mice are protected from bone loss caused by estrogen depletion. EMBO J. 1994 Mar 1;13(5):1189–1196. doi: 10.1002/j.1460-2075.1994.tb06368.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  74. Potter E., Behan D. P., Fischer W. H., Linton E. A., Lowry P. J., Vale W. W. Cloning and characterization of the cDNAs for human and rat corticotropin releasing factor-binding proteins. Nature. 1991 Jan 31;349(6308):423–426. doi: 10.1038/349423a0. [DOI] [PubMed] [Google Scholar]
  75. Potter E., Behan D. P., Linton E. A., Lowry P. J., Sawchenko P. E., Vale W. W. The central distribution of a corticotropin-releasing factor (CRF)-binding protein predicts multiple sites and modes of interaction with CRF. Proc Natl Acad Sci U S A. 1992 May 1;89(9):4192–4196. doi: 10.1073/pnas.89.9.4192. [DOI] [PMC free article] [PubMed] [Google Scholar]
  76. Pratt W. B. Interaction of hsp90 with steroid receptors: organizing some diverse observations and presenting the newest concepts. Mol Cell Endocrinol. 1990 Nov 12;74(1):C69–C76. doi: 10.1016/0303-7207(90)90198-h. [DOI] [PubMed] [Google Scholar]
  77. Radler-Pohl A., Gebel S., Sachsenmaier C., König H., Krämer M., Oehler T., Streile M., Ponta H., Rapp U., Rahmsdorf H. J. The activation and activity control of AP-1 (fos/jun). Ann N Y Acad Sci. 1993 Jun 11;684:127–148. doi: 10.1111/j.1749-6632.1993.tb32277.x. [DOI] [PubMed] [Google Scholar]
  78. Raveche E. S., Tjio J. H., Boegel W., Steinberg A. D. Studies of the effects of sex hormones on autosomal and X-linked genetic control of induced and spontaneous antibody production. Arthritis Rheum. 1979 Nov;22(11):1177–1187. doi: 10.1002/art.1780221104. [DOI] [PubMed] [Google Scholar]
  79. Rivier C., Rivier J., Lederis K., Vale W. In vitro and in vivo ACTH-releasing activity of ovine CRF, sauvagine and urotensin I. Regul Pept. 1983 Jan;5(2):139–143. doi: 10.1016/0167-0115(83)90121-0. [DOI] [PubMed] [Google Scholar]
  80. Rivier C., Vale W. Effect of the long-term administration of corticotropin-releasing factor on the pituitary-adrenal and pituitary-gonadal axis in the male rat. J Clin Invest. 1985 Feb;75(2):689–694. doi: 10.1172/JCI111748. [DOI] [PMC free article] [PubMed] [Google Scholar]
  81. Rivier C., Vale W. Modulation of stress-induced ACTH release by corticotropin-releasing factor, catecholamines and vasopressin. Nature. 1983 Sep 22;305(5932):325–327. doi: 10.1038/305325a0. [DOI] [PubMed] [Google Scholar]
  82. Rivier J., Rivier C., Vale W. Synthetic competitive antagonists of corticotropin-releasing factor: effect on ACTH secretion in the rat. Science. 1984 May 25;224(4651):889–891. doi: 10.1126/science.6326264. [DOI] [PubMed] [Google Scholar]
  83. Robinson B. G., Emanuel R. L., Frim D. M., Majzoub J. A. Glucocorticoid stimulates expression of corticotropin-releasing hormone gene in human placenta. Proc Natl Acad Sci U S A. 1988 Jul;85(14):5244–5248. doi: 10.1073/pnas.85.14.5244. [DOI] [PMC free article] [PubMed] [Google Scholar]
  84. Roche P. J., Crawford R. J., Fernley R. T., Tregear G. W., Coghlan J. P. Nucleotide sequence of the gene coding for ovine corticotropin-releasing factor and regulation of its mRNA levels by glucocorticoids. Gene. 1988 Nov 30;71(2):421–431. doi: 10.1016/0378-1119(88)90059-5. [DOI] [PubMed] [Google Scholar]
  85. Seasholtz A. F., Thompson R. C., Douglass J. O. Identification of a cyclic adenosine monophosphate-responsive element in the rat corticotropin-releasing hormone gene. Mol Endocrinol. 1988 Dec;2(12):1311–1319. doi: 10.1210/mend-2-12-1311. [DOI] [PubMed] [Google Scholar]
  86. Shibahara S., Morimoto Y., Furutani Y., Notake M., Takahashi H., Shimizu S., Horikawa S., Numa S. Isolation and sequence analysis of the human corticotropin-releasing factor precursor gene. EMBO J. 1983;2(5):775–779. doi: 10.1002/j.1460-2075.1983.tb01499.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  87. Shivers B. D., Harlan R. E., Morrell J. I., Pfaff D. W. Absence of oestradiol concentration in cell nuclei of LHRH-immunoreactive neurones. 1983 Jul 28-Aug 3Nature. 304(5924):345–347. doi: 10.1038/304345a0. [DOI] [PubMed] [Google Scholar]
  88. Sirinathsinghji D. J., Rees L. H., Rivier J., Vale W. Corticotropin-releasing factor is a potent inhibitor of sexual receptivity in the female rat. Nature. 1983 Sep 15;305(5931):232–235. doi: 10.1038/305232a0. [DOI] [PubMed] [Google Scholar]
  89. Slater E. P., Hesse H., Müller J. M., Beato M. Glucocorticoid receptor binding site in the mouse alpha-amylase 2 gene mediates response to the hormone. Mol Endocrinol. 1993 Jul;7(7):907–914. doi: 10.1210/mend.7.7.8413315. [DOI] [PubMed] [Google Scholar]
  90. Smith A. I., Funder J. W. Proopiomelanocortin processing in the pituitary, central nervous system, and peripheral tissues. Endocr Rev. 1988 Feb;9(1):159–179. doi: 10.1210/edrv-9-1-159. [DOI] [PubMed] [Google Scholar]
  91. Smith D. F., Toft D. O. Steroid receptors and their associated proteins. Mol Endocrinol. 1993 Jan;7(1):4–11. doi: 10.1210/mend.7.1.8446107. [DOI] [PubMed] [Google Scholar]
  92. Sobel D. O. Role of cyclic AMP in corticotropin releasing factor mediated ACTH release. Peptides. 1985 Jul-Aug;6(4):591–595. doi: 10.1016/0196-9781(85)90158-5. [DOI] [PubMed] [Google Scholar]
  93. Spengler D., Rupprecht R., Van L. P., Holsboer F. Identification and characterization of a 3',5'-cyclic adenosine monophosphate-responsive element in the human corticotropin-releasing hormone gene promoter. Mol Endocrinol. 1992 Nov;6(11):1931–1941. doi: 10.1210/mend.6.11.1480179. [DOI] [PubMed] [Google Scholar]
  94. Sternberg E. M., Hill J. M., Chrousos G. P., Kamilaris T., Listwak S. J., Gold P. W., Wilder R. L. Inflammatory mediator-induced hypothalamic-pituitary-adrenal axis activation is defective in streptococcal cell wall arthritis-susceptible Lewis rats. Proc Natl Acad Sci U S A. 1989 Apr;86(7):2374–2378. doi: 10.1073/pnas.86.7.2374. [DOI] [PMC free article] [PubMed] [Google Scholar]
  95. Sternberg E. M., Young W. S., 3rd, Bernardini R., Calogero A. E., Chrousos G. P., Gold P. W., Wilder R. L. A central nervous system defect in biosynthesis of corticotropin-releasing hormone is associated with susceptibility to streptococcal cell wall-induced arthritis in Lewis rats. Proc Natl Acad Sci U S A. 1989 Jun;86(12):4771–4775. doi: 10.1073/pnas.86.12.4771. [DOI] [PMC free article] [PubMed] [Google Scholar]
  96. Sutton R. E., Koob G. F., Le Moal M., Rivier J., Vale W. Corticotropin releasing factor produces behavioural activation in rats. Nature. 1982 May 27;297(5864):331–333. doi: 10.1038/297331a0. [DOI] [PubMed] [Google Scholar]
  97. Taylor A. L., Fishman L. M. Corticotropin-releasing hormone. N Engl J Med. 1988 Jul 28;319(4):213–222. doi: 10.1056/NEJM198807283190405. [DOI] [PubMed] [Google Scholar]
  98. Thompson R. C., Seasholtz A. F., Herbert E. Rat corticotropin-releasing hormone gene: sequence and tissue-specific expression. Mol Endocrinol. 1987 May;1(5):363–370. doi: 10.1210/mend-1-5-363. [DOI] [PubMed] [Google Scholar]
  99. Truss M., Beato M. Steroid hormone receptors: interaction with deoxyribonucleic acid and transcription factors. Endocr Rev. 1993 Aug;14(4):459–479. doi: 10.1210/edrv-14-4-459. [DOI] [PubMed] [Google Scholar]
  100. Tzukerman M., Zhang X. K., Pfahl M. Inhibition of estrogen receptor activity by the tumor promoter 12-O-tetradeconylphorbol-13-acetate: a molecular analysis. Mol Endocrinol. 1991 Dec;5(12):1983–1992. doi: 10.1210/mend-5-12-1983. [DOI] [PubMed] [Google Scholar]
  101. Ulisse S., Fabbri A., Dufau M. L. Corticotropin-releasing factor receptors and actions in rat Leydig cells. J Biol Chem. 1989 Feb 5;264(4):2156–2163. [PubMed] [Google Scholar]
  102. Vale W., Rivier C., Brown M. R., Spiess J., Koob G., Swanson L., Bilezikjian L., Bloom F., Rivier J. Chemical and biological characterization of corticotropin releasing factor. Recent Prog Horm Res. 1983;39:245–270. doi: 10.1016/b978-0-12-571139-5.50010-0. [DOI] [PubMed] [Google Scholar]
  103. Vale W., Spiess J., Rivier C., Rivier J. Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin. Science. 1981 Sep 18;213(4514):1394–1397. doi: 10.1126/science.6267699. [DOI] [PubMed] [Google Scholar]
  104. Vamvakopoulos N. C., Chrousos G. P. Evidence of direct estrogenic regulation of human corticotropin-releasing hormone gene expression. Potential implications for the sexual dimophism of the stress response and immune/inflammatory reaction. J Clin Invest. 1993 Oct;92(4):1896–1902. doi: 10.1172/JCI116782. [DOI] [PMC free article] [PubMed] [Google Scholar]
  105. Vamvakopoulos N. C., Chrousos G. P. Structural organization of the 5' flanking region of the human corticotropin releasing hormone gene. DNA Seq. 1993;4(3):197–206. doi: 10.3109/10425179309015632. [DOI] [PubMed] [Google Scholar]
  106. Vamvakopoulos N. C., Fukuhara K., Patchev V., Chrousos G. P. Effect of single and repeated immobilization stress on the heat shock protein 70/90 system of the rat: glucocorticoid-independent, reversible reduction of Hsp90 in the liver and spleen. Neuroendocrinology. 1993 Jun;57(6):1057–1065. doi: 10.1159/000126471. [DOI] [PubMed] [Google Scholar]
  107. Vamvakopoulos N. C., Mayol V., Margioris A. N., Chrousos G. P. Lack of dexamethasone modulation of mRNAs involved in the glucocorticoid signal transduction pathway in two cell systems. Steroids. 1992 Jun;57(6):282–287. doi: 10.1016/0039-128x(92)90061-d. [DOI] [PubMed] [Google Scholar]
  108. Vamvakopoulos N. C., Sioutopoulou T. O., Durkin S. A., Nierman W. C., Wasmuth J. J., McPherson J. D. Mapping the human corticotropin releasing hormone binding protein gene (CRHBP) to the long arm of chromosome 5 (5q11.2-q13.3). Genomics. 1995 Jan 1;25(1):325–327. doi: 10.1016/0888-7543(95)80151-b. [DOI] [PubMed] [Google Scholar]
  109. Vamvakopoulos N. C., Sioutopoulou T. O. Human corticotropin-releasing hormone receptor gene (CRHR) is located on the long arm of chromosome 17 (17q12-qter). Chromosome Res. 1994 Nov;2(6):471–473. doi: 10.1007/BF01552870. [DOI] [PubMed] [Google Scholar]
  110. Vamvakopoulos N. O. Tissue-specific expression of heat shock proteins 70 and 90: potential implication for differential sensitivity of tissues to glucocorticoids. Mol Cell Endocrinol. 1993 Dec;98(1):49–54. doi: 10.1016/0303-7207(93)90235-c. [DOI] [PubMed] [Google Scholar]
  111. Vita N., Laurent P., Lefort S., Chalon P., Lelias J. M., Kaghad M., Le Fur G., Caput D., Ferrara P. Primary structure and functional expression of mouse pituitary and human brain corticotrophin releasing factor receptors. FEBS Lett. 1993 Nov 29;335(1):1–5. doi: 10.1016/0014-5793(93)80427-v. [DOI] [PubMed] [Google Scholar]
  112. Whitcomb R. W., Linehan W. M., Wahl L. M., Knazek R. A. Monocytes stimulate cortisol production by cultured human adrenocortical cells. J Clin Endocrinol Metab. 1988 Jan;66(1):33–38. doi: 10.1210/jcem-66-1-33. [DOI] [PubMed] [Google Scholar]
  113. Wilder R. L., Calandra G. B., Garvin A. J., Wright K. D., Hansen C. T. Strain and sex variation in the susceptibility to streptococcal cell wall-induced polyarthritis in the rat. Arthritis Rheum. 1982 Sep;25(9):1064–1072. doi: 10.1002/art.1780250906. [DOI] [PubMed] [Google Scholar]
  114. Woloski B. M., Smith E. M., Meyer W. J., 3rd, Fuller G. M., Blalock J. E. Corticotropin-releasing activity of monokines. Science. 1985 Nov 29;230(4729):1035–1037. doi: 10.1126/science.2997929. [DOI] [PubMed] [Google Scholar]
  115. Yamamoto K. K., Gonzalez G. A., Menzel P., Rivier J., Montminy M. R. Characterization of a bipartite activator domain in transcription factor CREB. Cell. 1990 Feb 23;60(4):611–617. doi: 10.1016/0092-8674(90)90664-z. [DOI] [PubMed] [Google Scholar]
  116. Yamamoto K. R. Steroid receptor regulated transcription of specific genes and gene networks. Annu Rev Genet. 1985;19:209–252. doi: 10.1146/annurev.ge.19.120185.001233. [DOI] [PubMed] [Google Scholar]
  117. Zong J., Ashraf J., Thompson E. B. The promoter and first, untranslated exon of the human glucocorticoid receptor gene are GC rich but lack consensus glucocorticoid receptor element sites. Mol Cell Biol. 1990 Oct;10(10):5580–5585. doi: 10.1128/mcb.10.10.5580. [DOI] [PMC free article] [PubMed] [Google Scholar]

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