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. 1995 Sep;4(5):359–363. doi: 10.1155/S0962935195000585

Participation of the adrenal gland in the anti-inflammatory effect of polyunsaturated diets

V L F Silveira 1,✉, E A Limãos 1, D W Nunes 1
PMCID: PMC2365660  PMID: 18475665

Abstract

The effect of an n-3 (fish) and n-6 (soybean) fatty acid-rich diet on carrageenin paw oedema in rats, and the participation of adrenal gland, corticosterone and α2-macroglobulin (α2-M) in this process were studied. A significant inhibition of carrageenin oedema was observed not only in rats fed a diet rich in fish oil but also in the soybean group. α2-M was not detectable before carrageenin injection, suggesting that this putative antiinflammatory factor does not participate in the observed anti-inflammatory effect. Corticosterone levels were higher in fat-fed than in control rats, before carrageenin stimulus and adrenalectomy abolished the anti-inflammatory response in fat-fed animals, showing the important role of the adrenocortical hormones in this process.

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Selected References

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