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. 1995 Nov;4(6):431–436. doi: 10.1155/S096293519500069X

Nitric oxide synthase inhibition decreases tolerance to hyperoxia in newborn rats

M R Pierce 1,✉, C A Voelker 2, I R S Sosenko 3, S Bustamante 2, S M Olister 2, X-J Zhang 2, D A Clark 2, M J S Miller 2
PMCID: PMC2365667  PMID: 18475676

Abstract

We evaluated the effects of sustained perinatal inhibition of NO synthase (NOS) on hyperoxia induced lung injury in newborn rats. NG-nitro-Larginine-methyl-ester (L-NAME) or untreated water was administered to pregnant rats for the final 7 days of gestation and during lactation; followed by postnatal exposure to hyperoxia (>95% O2) or room air. The survival rate of L-NAME treated pups when placed in > 95% O2 at birth was significantly lower than controls from day 4 (L-NAME, 87%; control pups, 100%, p < 0.05) to 14 (L-NAME, 0%; control pups, 53%, p < 0.05). Foetal pulmonary artery vasoconstriction was induced by L-NAME with a decrease in internal diameter from 0.88 ± 0.03 mm to 0.64 ± 0.01 mm in control vs. L-NAME groups (p < 0.05), respectively. We conclude that perinatal NOS inhibition results in pulmonary artery vasoconstriction and a decreased tolerance to hyperoxia induced lung injury in newborn rats.

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Selected References

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