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. 1995 Nov;4(6):413–416. doi: 10.1155/S0962935195000664

Regulation of TXB2 and PGE2 production by TGF-β1 in in vitro silica dust-exposed rat alveolar macrophage

Urszula Orlinska 1,2,✉, Douglas C Kuhn 1
PMCID: PMC2365670  PMID: 18475673

Abstract

We investigated the effect of transforming factor factor-β1 (TGF-β1) on thromboxane B2 (TXB2) and prostaglandin E2 (PGE2) production in in vitro silica dust-exposed rat alveolar macrophages (AM). In the presence of 5 μg of anti-TGF-β1 antibodies, TXB2 production decreased, but PGE2 production increased. Addition of 2 ng of TGF-β1 to the culture medium potentiated TXB2 production, but PGE2 production apparently did not change. At 50 ng of TGF-β1, TXB2 production decreased, and PGE2 production varied. Our data suggest that in rat AM: (1) both endogenous and exogenous TGF-β1 regulate TXB2 production; and (2) in the absence of endogenous TGF-β1 the liberation of PGE2 increases; however, exogenous TGF-β1 does not have a regulatory effect on PGE2.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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