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. 1994 Feb;68(2):1239–1244. doi: 10.1128/jvi.68.2.1239-1244.1994

Adenovirus type 40 and 41 growth in vitro: host range diversity reflected by differences in patterns of DNA replication.

C T Tiemessen 1, A H Kidd 1
PMCID: PMC236569  PMID: 8289359

Abstract

Subgroup F adenoviruses adapt poorly to cell culture, but the reasons for their fastidious nature are as yet ill defined. In an attempt to gain an overview of the differences in replication between adenovirus type 2 (Ad2) and representative strains of Ad40 and Ad41, cell lines which show different degrees of permissiveness to Ad40 and Ad41 were infected and examined with respect to three key functions in the Ad2 life cycle: host protein shutoff, DNA synthesis, and late antigen synthesis. The complexity of growth patterns exhibited by the subgroup F adenoviruses suggests that defectiveness is a multifactorial phenomenon not easily explainable by a single aberrant function. Furthermore, results suggest that there may be replicative defects in subgroup F adenoviruses which are not shared by both serotypes or by all strains.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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