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. Author manuscript; available in PMC: 2008 May 2.
Published in final edited form as: Apoptosis. 2007 Jan;12(1):211–223. doi: 10.1007/s10495-006-0528-4

Fig. 2.

Fig. 2

Reovirus increases the susceptibility of human ovarian cancer cells to TRAIL-induced apoptosis. The ovarian cancer cell lines PA-1 and SKOV-3 were infected with reovirus (MOI 10) and were treated with TRAIL (20 ng/ml) for a further 4-6 h. Cells were then harvested, stained with FITC-labelled annexin V and propidium iodide and analyzed by flow cytometry. The number of cells that stained positive for annexin V but negative for propidium iodide (early apoptotic) is shown. Data obtained from PA-1 cells (A) and a graphical representation of results from PA-1 and SKOV-3 cell (B) is shown. The graph shows the percentage of early cells from 2 independent experiments. Error bars represent standard errors of the mean. The percentage of early apoptotic cells was significantly (P < 0.1,**) enhanced in PA-1 and SKOV-3 cells treated with reovirus and TRAIL compared to cells treated with TRAIL or reovirus alone