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. 1997 Jun;6(3):233–235. doi: 10.1080/09629359791730

Tumour necrosis factor-alpha (TNFα) stimulates the growth of human bone marrow stromal cells

F Rougier 1, E Cornu 2, N Gachard 1, V Praloran 1, Y Denizot 1,✉
PMCID: PMC2365834  PMID: 18472825

Abstract

This study reports that TNF-α is a potent mitogen for human bone marrow sternal cells in vitro (assessed by [3H]-thymidine incorporation into DNA and cell counts). In contrast, cytokines such as IL-1α, IL-1β, IL-2, IL-3, IL-4, IL-6, LIF, SCF, M-CSF, G-CSF and GM-CSF had no effect. The effect of TNF-α on the growth of human bone marrow stromal cells could be of importance during inflammatory processes which take place in the marrow, for example marrow fibrosis.

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Selected References

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