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. 1997 Jun;6(3):185–193. doi: 10.1080/09629359791677

Ionizing radiation enhances IL-6 and IL-8 production by human endothelial cells

A Van Der Meeren 1,✉, J-M Bertho 1, M Vandamme 1, M-H Gaugler 1
PMCID: PMC2365835  PMID: 18472819

Abstract

Irradiation exposure is known to induce an inflammatory reaction. Endothelial cells play a crucial role both in the inflammatory process and in radiation damage. Therefore, supernatants and cell lysates of 60Co-irradiated human umbilical vein endothelial cells (HUVEC) have been assessed for the presence of pro-inflammatory cytokines. After gamma irradiation, interleukin (IL)-1α, IL-1β and tumor necrosis factor (TNF)-α remained undetectable in both cell supernatants and cell lysates. However, a dose-dependent increase in the production of IL-6 and IL-8 has been demonstrated up to 6 days after exposure. These data indicate that the pro-inflammatory cytokines IL-6 and IL-8 may be involved in the inflammatory response of vascular endothelium induced by exposure to ionizing radiation.

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Selected References

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